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  1. Type I interferons are widely used in research applications and as biotherapeutics. Current assays used to measure interferon concentrations, such as plaque reduction assays and ELISA, are expensive, technical...

    Authors: Michael Puckette, J. Barrera, M. Schwarz and M. Rasmussen
    Citation: BMC Biotechnology 2022 22:13
  2. CRISPR-based programmable transcriptional activators (PTAs) are used in plants for rewiring gene networks. Better tuning of their activity in a time and dose-dependent manner should allow precise control of ge...

    Authors: Elena Garcia-Perez, Borja Diego-Martin, Alfredo Quijano-Rubio, Elena Moreno-Giménez, Sara Selma, Diego Orzaez and Marta Vazquez-Vilar
    Citation: BMC Biotechnology 2022 22:12
  3. Feathers are the most abundant agricultural waste produced by poultry farms. The accumulation of a large number of feathers not only seriously pollutes the environment but also causes the waste of protein reso...

    Authors: Naikun Shen, Mengying Yang, Chenjie Xie, Jiangxin Pan, Kunrong Pang, Hongyan Zhang, Yibing Wang and Mingguo Jiang
    Citation: BMC Biotechnology 2022 22:11
  4. Site-directed mutagenesis (SDM) is a key method in molecular biology; allowing to modify DNA sequences at single base pair resolution. Although many SDM methods have been developed, methods that increase effic...

    Authors: Shunit Olszakier and Shai Berlin
    Citation: BMC Biotechnology 2022 22:10
  5. Antrodia cinnamomea, a rare medicinal fungus, has been increasingly studied in recent years because of its abundant secondary metabolites which are beneficial to humans. However, there is a lack of research on it...

    Authors: JianZhi Chu, YongFei Ming, Qi Cui, Na Zheng, ShuDe Yang, WeiHuan Li, Hongwei Gao, Rui Zhang and XianHao Cheng
    Citation: BMC Biotechnology 2022 22:9
  6. Human matrix metalloproteinase 9 (hMMP9) is a biomarker in several diseases, including cancer, and the need for developing detectors and inhibitors of hMMP9 is increasing. As an antibody against hMMP9 can be s...

    Authors: Jina Ryu, Eun-Jung Kim, Joo-Kyung Kim, Tai Hyun Park, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:8
  7. One-step fermentation is a cheap way to produce xylo-oligosaccharides (XOS), where production of xylanases and XOS is integrated into a single process. In spite of cost advantage, one-step fermentation is stil...

    Authors: Jiawen Liu, Cong Liu, Shilei Qiao, Zhen Dong, Di Sun, Jingrong Zhu and Weijie Liu
    Citation: BMC Biotechnology 2022 22:6
  8. The fall armyworm, Spodoptera frugiperda, is a significant and widespread pest of maize, sorghum, rice, and other economically important crops. Successful management of this caterpillar pest has historically reli...

    Authors: Catherine E. Reavey, Adam S. Walker, Stephen P. Joyce, Lucy Broom, Alan Willse, Kyla Ercit, Mattia Poletto, Zoe H. Barnes, Thea Marubbi, Bartlomiej J. Troczka, David Treanor, Katherine Beadle, Ben Granville, Vanessa de Mello, Joss Teal, Edward Sulston…
    Citation: BMC Biotechnology 2022 22:5
  9. Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment. Thus, replacement of petroleum-based materials with new and effective renewable...

    Authors: Piwu Li, Fei Zhao, Xiaofeng Wei, Xiangling Tao and Feng Ding
    Citation: BMC Biotechnology 2022 22:4
  10. The present study intends to optimize the processing technology for the wine-processing of Rhizoma Coptidis, using alkaloids as indicators.

    Authors: Yunhong Wang, Weihan Qin, Yujie Yang, Hui Bai, Jirui Wang, Xiaomei Zhang, Yanlei Guo, Lei Hua and Yong Yang
    Citation: BMC Biotechnology 2022 22:3
  11. SHuffle is a suitable Escherichia coli (E. coli) strain for high yield cytoplasmic soluble expression of disulfide-bonded proteins such as Insulin due to its oxidative cytoplasmic condition and the ability to cor...

    Authors: Aida Bakhshi Khalilvand, Saeed Aminzadeh, Mohammad Hossein Sanati and Fereidoun Mahboudi
    Citation: BMC Biotechnology 2022 22:1
  12. Cyclin-dependent kinase 4 (CDK4) when hyperactivated drives development and maintenance of most tumour types, thus prompting its use as an essential cancer treatment target and a diagnostic tool. Target-bindin...

    Authors: Jialiang Zhao, Jingjing Xu, Tianbin Yang, Xinze Yu, Cheng Cheng, Tong Zhang, Ze Ren, Na Li, Fang Yang and Guiying Li
    Citation: BMC Biotechnology 2021 21:71
  13. Whole chloroplast genome (cpDNA) sequence is becoming widely used in the phylogenetic studies of plant and species identification, but in most cases the cpDNA were acquired from silica gel dried fresh leaves. ...

    Authors: Fang Li, Xuena Xie, Rong Huang, Enwei Tian, Chan Li and Zhi Chao
    Citation: BMC Biotechnology 2021 21:69
  14. Antibiotics have been widely used for the treatment of bacterial infections for decades. However, the rapid emergence of antibiotic-resistant bacteria has created many problems with a heavy burden for the medi...

    Authors: Khosro Zamani, Noushin Allah-Bakhshi, Faezeh Akhavan, Mahdieh Yousefi, Rezvan Golmoradi, Moazzameh Ramezani, Horacio Bach, Shabnam Razavi, Gholam-Reza Irajian, Mahyar Gerami, Ali Pakdin-Parizi, Majid Tafrihi and Fatemeh Ramezani
    Citation: BMC Biotechnology 2021 21:68
  15. We present computational modeling of positron emission tomography radiotracer uptake with consideration of blood flow and interstitial fluid flow, performing spatiotemporally-coupled modeling of uptake and int...

    Authors: Niloofar Fasaeiyan, M. Soltani, Farshad Moradi Kashkooli, Erfan Taatizadeh and Arman Rahmim
    Citation: BMC Biotechnology 2021 21:67
  16. Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintainin...

    Authors: Aurore Bodzen, Audrey Jossier, Sébastien Dupont, Pierre-Yves Mousset, Laurent Beney, Sophie Lafay and Patrick Gervais
    Citation: BMC Biotechnology 2021 21:66
  17. Lipases are triacylglycerol hydrolases that catalyze hydrolysis, esterification, interesterification, and transesterification reactions. These enzymes are targets of several industrial and biotech applications...

    Authors: Leticia Miranda Cesário, Giovanna Pinto Pires, Rafael Freitas Santos Pereira, Elisabete Fantuzzi, André da Silva Xavier, Servio Tulio Alves Cassini and Jairo Pinto de Oliveira
    Citation: BMC Biotechnology 2021 21:65
  18. Improved genome-editing via oviductal nucleic acids delivery (i-GONAD) is a new technology that facilitates in situ genome-editing of mammalian zygotes exiting the oviductal lumen. The i-GONAD technology has been...

    Authors: Takuya Aoshima, Yukari Kobayashi, Hisayoshi Takagi, Kenta Iijima, Masahiro Sato and Shuji Takabayashi
    Citation: BMC Biotechnology 2021 21:63
  19. Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) is a serine/threonine protein kinase regulated by the cell cycle. The purpose of this study was to obtain NEK2 protein to prepare an anti-NEK2 m...

    Authors: Qiuli Chen, Hui Li, Lichao Yang, Sha Wen, Xuejing Huang, Jiajuan Liu, Xiaoping Guo, Bing Hu, Gang Li and Min He
    Citation: BMC Biotechnology 2021 21:62
  20. There is a continued need for improved enzymes for industry. β-xylosidases are enzymes employed in a variety of industries and although many wild-type and engineered variants have been described, enzymes that ...

    Authors: Kanyisa Ndata, Walter Nevondo, Bongi Cekuse, Leonardo Joaquim van Zyl and Marla Trindade
    Citation: BMC Biotechnology 2021 21:61
  21. The current study was aimed at evaluating the role of the N-SH2 domain of SHP-2 as a partner protein in the expression of a toxic peptide, laterosporulin (LTS). We also investigated its effects on the formatio...

    Authors: Simin Salehzadeh, Mohammad Tabatabaei, Abdollah Derakhshandeh, Hamidreza Karbalaei-Heidari and Nasrin Kazemipour
    Citation: BMC Biotechnology 2021 21:60
  22. Published biocatalytic routes for accessing enantiopure 2-phenylpropanol using oxidoreductases afforded maximal product titers of only 80 mM. Enzyme deactivation was identified as the major limitation and was ...

    Authors: Christian Rapp, Simone Pival-Marko, Erika Tassano, Bernd Nidetzky and Regina Kratzer
    Citation: BMC Biotechnology 2021 21:58
  23. Even though tofu is a traditional Chinese food loved by Asian people the wastewater generated during the production of tofu can pollute the environment, and the treatment of this generated wastewater can incre...

    Authors: Tao Li, Chenyi Zhan, Gege Guo, Zhaoxing Liu, Ning Hao and Pingkai Ouyang
    Citation: BMC Biotechnology 2021 21:57
  24. Foodborne illness caused by Vibrio parahaemolyticus (V. parahaemolyticus) is generally associated with the consumption of seafood. Fish and other seafood can be contaminated with V. parahaemolyticus, natural inha...

    Authors: Jianan Liu, Ke Zhang, Jie Song, Hongyan Wu, Hongshun Hao, Jingran Bi, Hongman Hou and Gongliang Zhang
    Citation: BMC Biotechnology 2021 21:56
  25. The unnatural amino acid, L-2-aminobutyric acid (L-ABA) is an essential chiral building block for various pharmaceutical drugs, such as the antiepileptic drug levetiracetam and the antituberculosis drug ethamb...

    Authors: Zhiwei Zhang, Yang Liu, Jing Zhao, Wenqiang Li, Ruiwen Hu, Xia Li, Aitao Li, Yaping Wang and Lixin Ma
    Citation: BMC Biotechnology 2021 21:55
  26. With the emergence of CRISPR/Cas9 technology, multiple gene editing procedures became available for the silkworm. Although binary transgene-based methods have been widely used to generate mutants, delivery of ...

    Authors: Yun-long Zou, Ai-jun Ye, Shuo Liu, Wen-tao Wu, Li-feng Xu, Fang-yin Dai and Xiao-ling Tong
    Citation: BMC Biotechnology 2021 21:54
  27. In order to improve the taste acceptability of certain nutritional oils, it has been decided in this study to introduce them in an emulsion whose surfactant is casein, then to carry out a lacto-fermentation, l...

    Authors: Soumaya El Bouchikhi, Philippe Pagès, Azeddine Ibrahimi and Yahya Bensouda
    Citation: BMC Biotechnology 2021 21:53
  28. Equine chorionic gonadotropin (eCG), which comprises highly glycosylated α-subunit and β-subunit, is a unique member of the glycoprotein hormone family as it elicits both follicle-stimulating hormone (FSH)-lik...

    Authors: So-Yun Lee, Munkhzaya Byambaragchaa, Seung-Hee Choi, Han-Ju Kang, Myung-Hwa Kang and Kwan-Sik Min
    Citation: BMC Biotechnology 2021 21:52
  29. Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the ...

    Authors: Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed and Sahel Rahimi
    Citation: BMC Biotechnology 2021 21:51
  30. Although quantitative real-time PCR (qRT-PCR) is a common and sensitive method for miRNAs analysis, it is necessary to optimize conditions and minimize qRT-PCR inhibitors to achieve reliable results. The aim o...

    Authors: Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo and Eun Joo Song
    Citation: BMC Biotechnology 2021 21:50
  31. Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase nattokinase yields, fermentation conditions, strains, cultivation media, a...

    Authors: Yan Guangbo, Shu Min, Shen Wei, Ma Lixin, Zhai Chao, Wang Yaping and Huang Zunxi
    Citation: BMC Biotechnology 2021 21:49
  32. Extracellular microRNAs (miRNAs), released from cells into biofluids, have emerged as promising biomarkers for diagnostic and prognostic purposes. Several RNA isolation methods are available for the analysis o...

    Authors: Henk P. Roest, Jan N. M. IJzermans and Luc J. W. van der Laan
    Citation: BMC Biotechnology 2021 21:48
  33. Although laccase has a good catalytic oxidation ability, free laccase shows a poor stability. Enzyme immobilization is a common method to improve enzyme stability and endow the enzyme with reusability. Adsorpt...

    Authors: Zhaobo Wang, Dajun Ren, Shan Jiang, Hongyan Yu, Yaohui Cheng, Shuqin Zhang, Xiaoqing Zhang and Wangsheng Chen
    Citation: BMC Biotechnology 2021 21:47
  34. 4-vinylphenols produced by phenolic acid degradation catalyzed by phenolic acid decarboxylase can be used in food additives as well as flavor and fragrance industry. Improving the catalytic characters of pheno...

    Authors: Qin Li, Ying Xia, Ting Zhao, Yuanyuan Gong, Shangling Fang and Maobin Chen
    Citation: BMC Biotechnology 2021 21:44
  35. The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yi...

    Authors: Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes and Paula Meleady
    Citation: BMC Biotechnology 2021 21:43
  36. Protein C receptor (Procr) has recently been shown to mark resident adult stem cells in the mammary gland, vascular system, and pancreatic islets. More so, high Procr expression was also detected and used as i...

    Authors: Ting Wu, Yinghua Wang, Tianxiong Xiao, Yirui Ai, Jinsong Li, Yi Arial Zeng and Qing Cissy Yu
    Citation: BMC Biotechnology 2021 21:42
  37. CCR6 chemokine receptor is an important target in inflammatory diseases. Th17 cells express CCR6 and a number of inflammatory cytokines, including IL-17 and IL-22, which are involved in the propagation of infl...

    Authors: Sara Gómez-Melero, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Isaac Túnez-Fiñana and Elier Paz-Rojas
    Citation: BMC Biotechnology 2021 21:41
  38. Most commercial phycocyanins are extracted from a filamentous cyanobacterium, Arthrospira (Spirulina) platensis. Owing to the expenses of culture and complexities of the physical and chemical methods of phycocyan...

    Authors: Jinichi Aoki, Daisaku Sasaki and Munehiko Asayama
    Citation: BMC Biotechnology 2021 21:40
  39. HSPB5 is an ATP-independent molecular chaperone that is induced by heat shock or other proteotoxic stresses. HSPB5 is cytoprotective against stress both intracellularly and extracellularly. It acts as a potent...

    Authors: Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He and Yanzhong Hu
    Citation: BMC Biotechnology 2021 21:39
  40. Neuroinflammation has been identified to be the key player in most neurodegenerative diseases. If neuroinflammation is left to be unresolved, chronic neuroinflammation will be establish. Such situation is due ...

    Authors: M. A. F. Yahaya, A. R. Abu Bakar, J. Stanslas, N. Nordin, M. Zainol and M. Z. Mehat
    Citation: BMC Biotechnology 2021 21:38
  41. Laccases (EC are multi-copper oxidoreductases with great biotechnological importance due to their high oxidative potential and utility for removing synthetic dyes, oxidizing phenolic compounds, and d...

    Authors: Leidy D. Ardila-Leal, Pedro A. Monterey-Gutiérrez, Raúl A. Poutou-Piñales, Balkys E. Quevedo-Hidalgo, Johan F. Galindo and Aura M. Pedroza-Rodríguez
    Citation: BMC Biotechnology 2021 21:37
  42. DNA testing in the cattle industry undergoes multiple hurdles. Successful genotyping involves the transportation of samples from the field to the laboratory in a chilled environment followed by DNA extraction,...

    Authors: R. R. Alyethodi, U. Singh, S. Kumar, R. Alex, G. S. Sengar, T. V. Raja, R. Deb and B. Prakash
    Citation: BMC Biotechnology 2021 21:36
  43. The purpose of this study was to develop a reliable DNA extraction protocol to use on individual Teladorsagia circumcincta nematode specimens to produce high quality DNA for genome sequencing and phylogenetic ana...

    Authors: S. Sloan, C. J. Jenvey, D. Piedrafita, S. Preston and M. J. Stear
    Citation: BMC Biotechnology 2021 21:35

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