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  1. We present computational modeling of positron emission tomography radiotracer uptake with consideration of blood flow and interstitial fluid flow, performing spatiotemporally-coupled modeling of uptake and int...

    Authors: Niloofar Fasaeiyan, M. Soltani, Farshad Moradi Kashkooli, Erfan Taatizadeh and Arman Rahmim

    Citation: BMC Biotechnology 2021 21:67

    Content type: Research

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  2. Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintainin...

    Authors: Aurore Bodzen, Audrey Jossier, Sébastien Dupont, Pierre-Yves Mousset, Laurent Beney, Sophie Lafay and Patrick Gervais

    Citation: BMC Biotechnology 2021 21:66

    Content type: Research

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  3. Lipases are triacylglycerol hydrolases that catalyze hydrolysis, esterification, interesterification, and transesterification reactions. These enzymes are targets of several industrial and biotech applications...

    Authors: Leticia Miranda Cesário, Giovanna Pinto Pires, Rafael Freitas Santos Pereira, Elisabete Fantuzzi, André da Silva Xavier, Servio Tulio Alves Cassini and Jairo Pinto de Oliveira

    Citation: BMC Biotechnology 2021 21:65

    Content type: Research

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  4. Improved genome-editing via oviductal nucleic acids delivery (i-GONAD) is a new technology that facilitates in situ genome-editing of mammalian zygotes exiting the oviductal lumen. The i-GONAD technology has been...

    Authors: Takuya Aoshima, Yukari Kobayashi, Hisayoshi Takagi, Kenta Iijima, Masahiro Sato and Shuji Takabayashi

    Citation: BMC Biotechnology 2021 21:63

    Content type: Research

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  5. Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) is a serine/threonine protein kinase regulated by the cell cycle. The purpose of this study was to obtain NEK2 protein to prepare an anti-NEK2 m...

    Authors: Qiuli Chen, Hui Li, Lichao Yang, Sha Wen, Xuejing Huang, Jiajuan Liu, Xiaoping Guo, Bing Hu, Gang Li and Min He

    Citation: BMC Biotechnology 2021 21:62

    Content type: Research

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  6. There is a continued need for improved enzymes for industry. β-xylosidases are enzymes employed in a variety of industries and although many wild-type and engineered variants have been described, enzymes that ...

    Authors: Kanyisa Ndata, Walter Nevondo, Bongi Cekuse, Leonardo Joaquim van Zyl and Marla Trindade

    Citation: BMC Biotechnology 2021 21:61

    Content type: Research

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  7. The current study was aimed at evaluating the role of the N-SH2 domain of SHP-2 as a partner protein in the expression of a toxic peptide, laterosporulin (LTS). We also investigated its effects on the formatio...

    Authors: Simin Salehzadeh, Mohammad Tabatabaei, Abdollah Derakhshandeh, Hamidreza Karbalaei-Heidari and Nasrin Kazemipour

    Citation: BMC Biotechnology 2021 21:60

    Content type: Research

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  8. Published biocatalytic routes for accessing enantiopure 2-phenylpropanol using oxidoreductases afforded maximal product titers of only 80 mM. Enzyme deactivation was identified as the major limitation and was ...

    Authors: Christian Rapp, Simone Pival-Marko, Erika Tassano, Bernd Nidetzky and Regina Kratzer

    Citation: BMC Biotechnology 2021 21:58

    Content type: Research article

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  9. Even though tofu is a traditional Chinese food loved by Asian people the wastewater generated during the production of tofu can pollute the environment, and the treatment of this generated wastewater can incre...

    Authors: Tao Li, Chenyi Zhan, Gege Guo, Zhaoxing Liu, Ning Hao and Pingkai Ouyang

    Citation: BMC Biotechnology 2021 21:57

    Content type: Research

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  10. Foodborne illness caused by Vibrio parahaemolyticus (V. parahaemolyticus) is generally associated with the consumption of seafood. Fish and other seafood can be contaminated with V. parahaemolyticus, natural inha...

    Authors: Jianan Liu, Ke Zhang, Jie Song, Hongyan Wu, Hongshun Hao, Jingran Bi, Hongman Hou and Gongliang Zhang

    Citation: BMC Biotechnology 2021 21:56

    Content type: Research

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  11. The unnatural amino acid, L-2-aminobutyric acid (L-ABA) is an essential chiral building block for various pharmaceutical drugs, such as the antiepileptic drug levetiracetam and the antituberculosis drug ethamb...

    Authors: Zhiwei Zhang, Yang Liu, Jing Zhao, Wenqiang Li, Ruiwen Hu, Xia Li, Aitao Li, Yaping Wang and Lixin Ma

    Citation: BMC Biotechnology 2021 21:55

    Content type: Research article

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  12. With the emergence of CRISPR/Cas9 technology, multiple gene editing procedures became available for the silkworm. Although binary transgene-based methods have been widely used to generate mutants, delivery of ...

    Authors: Yun-long Zou, Ai-jun Ye, Shuo Liu, Wen-tao Wu, Li-feng Xu, Fang-yin Dai and Xiao-ling Tong

    Citation: BMC Biotechnology 2021 21:54

    Content type: Methodology article

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  13. In order to improve the taste acceptability of certain nutritional oils, it has been decided in this study to introduce them in an emulsion whose surfactant is casein, then to carry out a lacto-fermentation, l...

    Authors: Soumaya El Bouchikhi, Philippe Pagès, Azeddine Ibrahimi and Yahya Bensouda

    Citation: BMC Biotechnology 2021 21:53

    Content type: Research article

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  14. Equine chorionic gonadotropin (eCG), which comprises highly glycosylated α-subunit and β-subunit, is a unique member of the glycoprotein hormone family as it elicits both follicle-stimulating hormone (FSH)-lik...

    Authors: So-Yun Lee, Munkhzaya Byambaragchaa, Seung-Hee Choi, Han-Ju Kang, Myung-Hwa Kang and Kwan-Sik Min

    Citation: BMC Biotechnology 2021 21:52

    Content type: Research

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  15. Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the ...

    Authors: Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed and Sahel Rahimi

    Citation: BMC Biotechnology 2021 21:51

    Content type: Research

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  16. Although quantitative real-time PCR (qRT-PCR) is a common and sensitive method for miRNAs analysis, it is necessary to optimize conditions and minimize qRT-PCR inhibitors to achieve reliable results. The aim o...

    Authors: Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo and Eun Joo Song

    Citation: BMC Biotechnology 2021 21:50

    Content type: Methodology article

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  17. Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase nattokinase yields, fermentation conditions, strains, cultivation media, a...

    Authors: Yan Guangbo, Shu Min, Shen Wei, Ma Lixin, Zhai Chao, Wang Yaping and Huang Zunxi

    Citation: BMC Biotechnology 2021 21:49

    Content type: Research

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  18. Extracellular microRNAs (miRNAs), released from cells into biofluids, have emerged as promising biomarkers for diagnostic and prognostic purposes. Several RNA isolation methods are available for the analysis o...

    Authors: Henk P. Roest, Jan N. M. IJzermans and Luc J. W. van der Laan

    Citation: BMC Biotechnology 2021 21:48

    Content type: Research article

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  19. Although laccase has a good catalytic oxidation ability, free laccase shows a poor stability. Enzyme immobilization is a common method to improve enzyme stability and endow the enzyme with reusability. Adsorpt...

    Authors: Zhaobo Wang, Dajun Ren, Shan Jiang, Hongyan Yu, Yaohui Cheng, Shuqin Zhang, Xiaoqing Zhang and Wangsheng Chen

    Citation: BMC Biotechnology 2021 21:47

    Content type: Research

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  20. 4-vinylphenols produced by phenolic acid degradation catalyzed by phenolic acid decarboxylase can be used in food additives as well as flavor and fragrance industry. Improving the catalytic characters of pheno...

    Authors: Qin Li, Ying Xia, Ting Zhao, Yuanyuan Gong, Shangling Fang and Maobin Chen

    Citation: BMC Biotechnology 2021 21:44

    Content type: Research

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  21. The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yi...

    Authors: Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes and Paula Meleady

    Citation: BMC Biotechnology 2021 21:43

    Content type: Research

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  22. Protein C receptor (Procr) has recently been shown to mark resident adult stem cells in the mammary gland, vascular system, and pancreatic islets. More so, high Procr expression was also detected and used as i...

    Authors: Ting Wu, Yinghua Wang, Tianxiong Xiao, Yirui Ai, Jinsong Li, Yi Arial Zeng and Qing Cissy Yu

    Citation: BMC Biotechnology 2021 21:42

    Content type: Research

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  23. CCR6 chemokine receptor is an important target in inflammatory diseases. Th17 cells express CCR6 and a number of inflammatory cytokines, including IL-17 and IL-22, which are involved in the propagation of infl...

    Authors: Sara Gómez-Melero, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Isaac Túnez-Fiñana and Elier Paz-Rojas

    Citation: BMC Biotechnology 2021 21:41

    Content type: Research

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  24. Most commercial phycocyanins are extracted from a filamentous cyanobacterium, Arthrospira (Spirulina) platensis. Owing to the expenses of culture and complexities of the physical and chemical methods of phycocyan...

    Authors: Jinichi Aoki, Daisaku Sasaki and Munehiko Asayama

    Citation: BMC Biotechnology 2021 21:40

    Content type: Research

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  25. HSPB5 is an ATP-independent molecular chaperone that is induced by heat shock or other proteotoxic stresses. HSPB5 is cytoprotective against stress both intracellularly and extracellularly. It acts as a potent...

    Authors: Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He and Yanzhong Hu

    Citation: BMC Biotechnology 2021 21:39

    Content type: Research

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  26. Neuroinflammation has been identified to be the key player in most neurodegenerative diseases. If neuroinflammation is left to be unresolved, chronic neuroinflammation will be establish. Such situation is due ...

    Authors: M. A. F. Yahaya, A. R. Abu Bakar, J. Stanslas, N. Nordin, M. Zainol and M. Z. Mehat

    Citation: BMC Biotechnology 2021 21:38

    Content type: Research

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  27. Laccases (EC 1.10.3.2) are multi-copper oxidoreductases with great biotechnological importance due to their high oxidative potential and utility for removing synthetic dyes, oxidizing phenolic compounds, and d...

    Authors: Leidy D. Ardila-Leal, Pedro A. Monterey-Gutiérrez, Raúl A. Poutou-Piñales, Balkys E. Quevedo-Hidalgo, Johan F. Galindo and Aura M. Pedroza-Rodríguez

    Citation: BMC Biotechnology 2021 21:37

    Content type: Research

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  28. DNA testing in the cattle industry undergoes multiple hurdles. Successful genotyping involves the transportation of samples from the field to the laboratory in a chilled environment followed by DNA extraction,...

    Authors: R. R. Alyethodi, U. Singh, S. Kumar, R. Alex, G. S. Sengar, T. V. Raja, R. Deb and B. Prakash

    Citation: BMC Biotechnology 2021 21:36

    Content type: Methodology article

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  29. The purpose of this study was to develop a reliable DNA extraction protocol to use on individual Teladorsagia circumcincta nematode specimens to produce high quality DNA for genome sequencing and phylogenetic ana...

    Authors: S. Sloan, C. J. Jenvey, D. Piedrafita, S. Preston and M. J. Stear

    Citation: BMC Biotechnology 2021 21:35

    Content type: Research article

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  30. Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria. Antibiotic therapy and the use of diphtheria antitoxin is a...

    Authors: Morteza Rezaeifard, Roya Solhi, Mohammad Mohammadi, Ebrahim Abbasi and Mahdi Aminian

    Citation: BMC Biotechnology 2021 21:34

    Content type: Research article

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  31. Amylases produced by fungi during solid-state fermentation are the most widely used commercial enzymes to meet the ever-increasing demands of the global enzyme market. The use of low-cost substrates to curtail...

    Authors: M. Balakrishnan, G. Jeevarathinam, S. Kiran Santhosh Kumar, Iniyakumar Muniraj and Sivakumar Uthandi

    Citation: BMC Biotechnology 2021 21:33

    Content type: Research article

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  32. Microorganisms, including Bacillus species are used to help control plant pathogens, thereby reducing reliance on synthetic pesticides in agriculture. Bacillus velezensis strain 1B-23 has been shown to reduce sym...

    Authors: Michelle S. M. Li, David A. Piccoli, Tim McDowell, Jacqueline MacDonald, Justin Renaud and Ze-Chun Yuan

    Citation: BMC Biotechnology 2021 21:31

    Content type: Research

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  33. Bovine viral diarrhea virus (BVDV) is a major economic disease that has been spread in most countries. In addition to vaccination, one of the main ways to control the disease and prevent it from spreading is t...

    Authors: Zahra Heidari, Seyedeh Elham Rezatofighi and Saadat Rastegarzadeh

    Citation: BMC Biotechnology 2021 21:30

    Content type: Research article

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  34. Quantitative analysis of differential gene expression is of central importance in molecular life sciences. The Gene eXpression Profiling technology (GeXP) relies on multiplex RT-PCR and subsequent capillary el...

    Authors: Pauline Marquardt, Britta Werthmann, Viktoria Rätzel, Markus Haas and Wolfgang Marwan

    Citation: BMC Biotechnology 2021 21:29

    Content type: Methodology article

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  35. Microbial polysaccharides have been reported to possess remarkable bioactivities. Physarum polycephalum is a species of slime mold for which the microplasmodia are capable of rapid growth and can produce a signif...

    Authors: Tuyen T. H. Do, Tran N. B. Lai, Steven L. Stephenson and Hanh T. M. Tran

    Citation: BMC Biotechnology 2021 21:28

    Content type: Research article

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  36. Phakopsora pachyrhizi is a biotrophic fungal pathogen responsible for the Asian soybean rust disease causing important yield losses in tropical and subtropical soybean-producing countries. P. pachyrhizi triggers ...

    Authors: L. Cabre, S. Peyrard, C. Sirven, L. Gilles, B. Pelissier, S. Ducerf and N. Poussereau

    Citation: BMC Biotechnology 2021 21:27

    Content type: Research article

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  37. The production of agricultural wastes still growing as a consequence of the population growing. However, the majority of these residues are under-utilized due their chemical composition, which is mainly compos...

    Authors: Martha María Arevalos-Sánchez, Adrián Omar Maynez-Perez, Felipe A. Rodríguez-Almeida, José Alfredo Martínez-Quintana, Fidel Alejandro Sanchez-Flores, Monserrath Felix-Portillo, América Chavéz-Martínez, Myrna Elena Olvera-García, Oscar Ruiz-Barrera and Agustín Corral-Luna

    Citation: BMC Biotechnology 2021 21:26

    Content type: Research article

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  38. Ogataea polymorpha is a thermotolerant, methylotrophic yeast with significant industrial applications. While previously mainly used for protein synthesis, it also holds promise for producing platform chemicals. O...

    Authors: Ulf W Liebal, Brigida A Fabry, Aarthi Ravikrishnan, Constantin VL Schedel, Simone Schmitz, Lars M Blank and Birgitta E Ebert

    Citation: BMC Biotechnology 2021 21:23

    Content type: Research article

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  39. The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify t...

    Authors: Masoumeh Adhami, Balal Sadeghi, Ali Rezapour, Ali Akbar Haghdoost and Habib MotieGhader

    Citation: BMC Biotechnology 2021 21:22

    Content type: Research article

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  40. Proteases are important for hydrolysis of proteins to generate peptides with many bioactivities. Thus, the development of novel proteases with high activities is meaningful to discover bioactive peptides. Beca...

    Authors: Chang Chang, Siyi Gong, Zhiping Liu, Qiaojuan Yan and Zhengqiang Jiang

    Citation: BMC Biotechnology 2021 21:21

    Content type: Research article

    Published on:

  41. Over the past decade, therapeutic messenger RNAs (mRNAs) have emerged as a highly promising new class of drugs for protein replacement therapies. Due to the recent developments, the incorporation of modified n...

    Authors: Cynthia Aslan, Seyed Hossein Kiaie, Naime Majidi Zolbanin, Parisa Lotfinejad, Reihaneh Ramezani, Fatah Kashanchi and Reza Jafari

    Citation: BMC Biotechnology 2021 21:20

    Content type: Review

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  42. Alanine decarboxylase (AlaDC), specifically present in tea plants, is crucial for theanine biosynthesis. Serine decarboxylase (SDC), found in many plants, is a protein most closely related to AlaDC. To investi...

    Authors: Peixian Bai, Liyuan Wang, Kang Wei, Li Ruan, Liyun Wu, Mengdi He, Dejiang Ni and Hao Cheng

    Citation: BMC Biotechnology 2021 21:17

    Content type: Research article

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