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  1. Lymphocytic leukemia (LL) is a primary malignant tumor of hematopoietic tissue, which seriously affects the health of children and the elderly. The study aims to establish a new detection method for screening ...

    Authors: Zhen Zhang, Jintao Zhang, Shanshan Dai and Hang Xu
    Citation: BMC Biotechnology 2022 22:27
  2. With the growing concern for the environment, there are trends that bio-utilization of keratinous waste by keratinases could ease the heavy burden of keratinous waste from the poultry processing and leather in...

    Authors: Rong-Xian Zhang, Zhong-Wei Wu, Hai-Yang Cui, Ying-Nan Chai, Cheng-Wei Hua, Peng Wang, Lan Li and Tian-You Yang
    Citation: BMC Biotechnology 2022 22:26
  3. The chicken in ovo model is an attractive system to explore underlying mechanisms of neural and brain development, and it is important to develop effective genetic modification techniques that permit analyses ...

    Authors: Kyung Min Jung, Kyung Je Park, Young Min Kim and Jae Yong Han
    Citation: BMC Biotechnology 2022 22:25
  4. The metabolic engineering of high-biomass crops for lipid production in their vegetative biomass has recently been proposed as a strategy to elevate energy density and lipid yields for biodiesel production. En...

    Authors: Guangbin Luo, Viet Dang Cao, Baskaran Kannan, Hui Liu, John Shanklin and Fredy Altpeter
    Citation: BMC Biotechnology 2022 22:24
  5. Temporomandibular disorder (TMD) refers to a group of disorders that affect temporomandibular joint (TMJ) and its associated muscles with very limited treatment options. Stem cell research is emerging as one o...

    Authors: Vesna Karic, Rahul Chandran and Heidi Abrahamse
    Citation: BMC Biotechnology 2022 22:23
  6. The PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies show that therapeutic antibodies blocking the PD-1 pathway can restore...

    Authors: Sepideh Safaei Ghaderi, Farhad Riazi-Rad, Elmira Safaie Qamsari, Salman Bagheri, Fatemeh Rahimi-Jamnani and Zahra Sharifzadeh
    Citation: BMC Biotechnology 2022 22:22
  7. Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen that causes nosocomial infections and often exhibits antibiotic resistance. Therefore, the development of an accurate method for detecting P. aeruginosa ...

    Authors: Gyu-Min Lim, Joo-Kyung Kim, Eun-Jung Kim, Chang-Soo Lee, Wooseong Kim, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:21
  8. Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal...

    Authors: Dong-Ern Kim, Ji-Hye Lee, Kuk-Bin Ji, Kang-Sun Park, Tae-Young Kil, Okjae Koo and Min-Kyu Kim
    Citation: BMC Biotechnology 2022 22:19
  9. Tetramethylpyrazine (TTMP) is a flavoring additive that significantly contributes to the formation of flavor compounds in soybean-based fermented foods. Over recent years, the application of TTMP in the food i...

    Authors: Zhenli Liu, Yongjun Wu, Lincheng Zhang, Shuoqiu Tong, Jing Jin, Xian Gong and Jie Zhong
    Citation: BMC Biotechnology 2022 22:18
  10. Mass vaccination of dogs as important rabies reservoir is proposed to most effectively reduce and eliminate rabies also in humans. However, a minimum coverage of 70% needs to be achieved for control of the dis...

    Authors: Khaled Trabelsi, Meriem Ben Zakour, Ingo Jordan, Volker Sandig, Samia Rourou and Hela Kallel
    Citation: BMC Biotechnology 2022 22:17
  11. The aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system (SEDDS).

    Authors: Yunhong Wang, Jingcai Chen, Yang Yang, Sijia Gao, Zhuzhu Wang, Yating Liu, Xiaomei Zhang, Lei Hua, Yanlei Guo and Yong Yang
    Citation: BMC Biotechnology 2022 22:16
  12. The discovery of the CRISPR-Cas9 system and its applicability in mammalian embryos has revolutionized the way we generate genetically engineered animal models. To date, models harbouring conditional alleles (i...

    Authors: Guillaume Bernas, Mariette Ouellet, Andréa Barrios, Hélène Jamann, Catherine Larochelle, Émile Lévy and Jean-François Schmouth
    Citation: BMC Biotechnology 2022 22:14
  13. Type I interferons are widely used in research applications and as biotherapeutics. Current assays used to measure interferon concentrations, such as plaque reduction assays and ELISA, are expensive, technical...

    Authors: Michael Puckette, J. Barrera, M. Schwarz and M. Rasmussen
    Citation: BMC Biotechnology 2022 22:13
  14. CRISPR-based programmable transcriptional activators (PTAs) are used in plants for rewiring gene networks. Better tuning of their activity in a time and dose-dependent manner should allow precise control of ge...

    Authors: Elena Garcia-Perez, Borja Diego-Martin, Alfredo Quijano-Rubio, Elena Moreno-Giménez, Sara Selma, Diego Orzaez and Marta Vazquez-Vilar
    Citation: BMC Biotechnology 2022 22:12
  15. Feathers are the most abundant agricultural waste produced by poultry farms. The accumulation of a large number of feathers not only seriously pollutes the environment but also causes the waste of protein reso...

    Authors: Naikun Shen, Mengying Yang, Chenjie Xie, Jiangxin Pan, Kunrong Pang, Hongyan Zhang, Yibing Wang and Mingguo Jiang
    Citation: BMC Biotechnology 2022 22:11
  16. Site-directed mutagenesis (SDM) is a key method in molecular biology; allowing to modify DNA sequences at single base pair resolution. Although many SDM methods have been developed, methods that increase effic...

    Authors: Shunit Olszakier and Shai Berlin
    Citation: BMC Biotechnology 2022 22:10
  17. Antrodia cinnamomea, a rare medicinal fungus, has been increasingly studied in recent years because of its abundant secondary metabolites which are beneficial to humans. However, there is a lack of research on it...

    Authors: JianZhi Chu, YongFei Ming, Qi Cui, Na Zheng, ShuDe Yang, WeiHuan Li, Hongwei Gao, Rui Zhang and XianHao Cheng
    Citation: BMC Biotechnology 2022 22:9
  18. Human matrix metalloproteinase 9 (hMMP9) is a biomarker in several diseases, including cancer, and the need for developing detectors and inhibitors of hMMP9 is increasing. As an antibody against hMMP9 can be s...

    Authors: Jina Ryu, Eun-Jung Kim, Joo-Kyung Kim, Tai Hyun Park, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:8
  19. One-step fermentation is a cheap way to produce xylo-oligosaccharides (XOS), where production of xylanases and XOS is integrated into a single process. In spite of cost advantage, one-step fermentation is stil...

    Authors: Jiawen Liu, Cong Liu, Shilei Qiao, Zhen Dong, Di Sun, Jingrong Zhu and Weijie Liu
    Citation: BMC Biotechnology 2022 22:6
  20. The fall armyworm, Spodoptera frugiperda, is a significant and widespread pest of maize, sorghum, rice, and other economically important crops. Successful management of this caterpillar pest has historically reli...

    Authors: Catherine E. Reavey, Adam S. Walker, Stephen P. Joyce, Lucy Broom, Alan Willse, Kyla Ercit, Mattia Poletto, Zoe H. Barnes, Thea Marubbi, Bartlomiej J. Troczka, David Treanor, Katherine Beadle, Ben Granville, Vanessa de Mello, Joss Teal, Edward Sulston…
    Citation: BMC Biotechnology 2022 22:5
  21. Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment. Thus, replacement of petroleum-based materials with new and effective renewable...

    Authors: Piwu Li, Fei Zhao, Xiaofeng Wei, Xiangling Tao and Feng Ding
    Citation: BMC Biotechnology 2022 22:4
  22. The present study intends to optimize the processing technology for the wine-processing of Rhizoma Coptidis, using alkaloids as indicators.

    Authors: Yunhong Wang, Weihan Qin, Yujie Yang, Hui Bai, Jirui Wang, Xiaomei Zhang, Yanlei Guo, Lei Hua and Yong Yang
    Citation: BMC Biotechnology 2022 22:3
  23. SHuffle is a suitable Escherichia coli (E. coli) strain for high yield cytoplasmic soluble expression of disulfide-bonded proteins such as Insulin due to its oxidative cytoplasmic condition and the ability to cor...

    Authors: Aida Bakhshi Khalilvand, Saeed Aminzadeh, Mohammad Hossein Sanati and Fereidoun Mahboudi
    Citation: BMC Biotechnology 2022 22:1
  24. Cyclin-dependent kinase 4 (CDK4) when hyperactivated drives development and maintenance of most tumour types, thus prompting its use as an essential cancer treatment target and a diagnostic tool. Target-bindin...

    Authors: Jialiang Zhao, Jingjing Xu, Tianbin Yang, Xinze Yu, Cheng Cheng, Tong Zhang, Ze Ren, Na Li, Fang Yang and Guiying Li
    Citation: BMC Biotechnology 2021 21:71
  25. Whole chloroplast genome (cpDNA) sequence is becoming widely used in the phylogenetic studies of plant and species identification, but in most cases the cpDNA were acquired from silica gel dried fresh leaves. ...

    Authors: Fang Li, Xuena Xie, Rong Huang, Enwei Tian, Chan Li and Zhi Chao
    Citation: BMC Biotechnology 2021 21:69
  26. Antibiotics have been widely used for the treatment of bacterial infections for decades. However, the rapid emergence of antibiotic-resistant bacteria has created many problems with a heavy burden for the medi...

    Authors: Khosro Zamani, Noushin Allah-Bakhshi, Faezeh Akhavan, Mahdieh Yousefi, Rezvan Golmoradi, Moazzameh Ramezani, Horacio Bach, Shabnam Razavi, Gholam-Reza Irajian, Mahyar Gerami, Ali Pakdin-Parizi, Majid Tafrihi and Fatemeh Ramezani
    Citation: BMC Biotechnology 2021 21:68
  27. We present computational modeling of positron emission tomography radiotracer uptake with consideration of blood flow and interstitial fluid flow, performing spatiotemporally-coupled modeling of uptake and int...

    Authors: Niloofar Fasaeiyan, M. Soltani, Farshad Moradi Kashkooli, Erfan Taatizadeh and Arman Rahmim
    Citation: BMC Biotechnology 2021 21:67
  28. Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintainin...

    Authors: Aurore Bodzen, Audrey Jossier, Sébastien Dupont, Pierre-Yves Mousset, Laurent Beney, Sophie Lafay and Patrick Gervais
    Citation: BMC Biotechnology 2021 21:66
  29. Lipases are triacylglycerol hydrolases that catalyze hydrolysis, esterification, interesterification, and transesterification reactions. These enzymes are targets of several industrial and biotech applications...

    Authors: Leticia Miranda Cesário, Giovanna Pinto Pires, Rafael Freitas Santos Pereira, Elisabete Fantuzzi, André da Silva Xavier, Servio Tulio Alves Cassini and Jairo Pinto de Oliveira
    Citation: BMC Biotechnology 2021 21:65
  30. Improved genome-editing via oviductal nucleic acids delivery (i-GONAD) is a new technology that facilitates in situ genome-editing of mammalian zygotes exiting the oviductal lumen. The i-GONAD technology has been...

    Authors: Takuya Aoshima, Yukari Kobayashi, Hisayoshi Takagi, Kenta Iijima, Masahiro Sato and Shuji Takabayashi
    Citation: BMC Biotechnology 2021 21:63
  31. Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) is a serine/threonine protein kinase regulated by the cell cycle. The purpose of this study was to obtain NEK2 protein to prepare an anti-NEK2 m...

    Authors: Qiuli Chen, Hui Li, Lichao Yang, Sha Wen, Xuejing Huang, Jiajuan Liu, Xiaoping Guo, Bing Hu, Gang Li and Min He
    Citation: BMC Biotechnology 2021 21:62
  32. There is a continued need for improved enzymes for industry. β-xylosidases are enzymes employed in a variety of industries and although many wild-type and engineered variants have been described, enzymes that ...

    Authors: Kanyisa Ndata, Walter Nevondo, Bongi Cekuse, Leonardo Joaquim van Zyl and Marla Trindade
    Citation: BMC Biotechnology 2021 21:61
  33. The current study was aimed at evaluating the role of the N-SH2 domain of SHP-2 as a partner protein in the expression of a toxic peptide, laterosporulin (LTS). We also investigated its effects on the formatio...

    Authors: Simin Salehzadeh, Mohammad Tabatabaei, Abdollah Derakhshandeh, Hamidreza Karbalaei-Heidari and Nasrin Kazemipour
    Citation: BMC Biotechnology 2021 21:60
  34. Published biocatalytic routes for accessing enantiopure 2-phenylpropanol using oxidoreductases afforded maximal product titers of only 80 mM. Enzyme deactivation was identified as the major limitation and was ...

    Authors: Christian Rapp, Simone Pival-Marko, Erika Tassano, Bernd Nidetzky and Regina Kratzer
    Citation: BMC Biotechnology 2021 21:58
  35. Even though tofu is a traditional Chinese food loved by Asian people the wastewater generated during the production of tofu can pollute the environment, and the treatment of this generated wastewater can incre...

    Authors: Tao Li, Chenyi Zhan, Gege Guo, Zhaoxing Liu, Ning Hao and Pingkai Ouyang
    Citation: BMC Biotechnology 2021 21:57
  36. Foodborne illness caused by Vibrio parahaemolyticus (V. parahaemolyticus) is generally associated with the consumption of seafood. Fish and other seafood can be contaminated with V. parahaemolyticus, natural inha...

    Authors: Jianan Liu, Ke Zhang, Jie Song, Hongyan Wu, Hongshun Hao, Jingran Bi, Hongman Hou and Gongliang Zhang
    Citation: BMC Biotechnology 2021 21:56
  37. The unnatural amino acid, L-2-aminobutyric acid (L-ABA) is an essential chiral building block for various pharmaceutical drugs, such as the antiepileptic drug levetiracetam and the antituberculosis drug ethamb...

    Authors: Zhiwei Zhang, Yang Liu, Jing Zhao, Wenqiang Li, Ruiwen Hu, Xia Li, Aitao Li, Yaping Wang and Lixin Ma
    Citation: BMC Biotechnology 2021 21:55
  38. With the emergence of CRISPR/Cas9 technology, multiple gene editing procedures became available for the silkworm. Although binary transgene-based methods have been widely used to generate mutants, delivery of ...

    Authors: Yun-long Zou, Ai-jun Ye, Shuo Liu, Wen-tao Wu, Li-feng Xu, Fang-yin Dai and Xiao-ling Tong
    Citation: BMC Biotechnology 2021 21:54
  39. In order to improve the taste acceptability of certain nutritional oils, it has been decided in this study to introduce them in an emulsion whose surfactant is casein, then to carry out a lacto-fermentation, l...

    Authors: Soumaya El Bouchikhi, Philippe Pagès, Azeddine Ibrahimi and Yahya Bensouda
    Citation: BMC Biotechnology 2021 21:53
  40. Equine chorionic gonadotropin (eCG), which comprises highly glycosylated α-subunit and β-subunit, is a unique member of the glycoprotein hormone family as it elicits both follicle-stimulating hormone (FSH)-lik...

    Authors: So-Yun Lee, Munkhzaya Byambaragchaa, Seung-Hee Choi, Han-Ju Kang, Myung-Hwa Kang and Kwan-Sik Min
    Citation: BMC Biotechnology 2021 21:52
  41. Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the ...

    Authors: Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed and Sahel Rahimi
    Citation: BMC Biotechnology 2021 21:51
  42. Although quantitative real-time PCR (qRT-PCR) is a common and sensitive method for miRNAs analysis, it is necessary to optimize conditions and minimize qRT-PCR inhibitors to achieve reliable results. The aim o...

    Authors: Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo and Eun Joo Song
    Citation: BMC Biotechnology 2021 21:50
  43. Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase nattokinase yields, fermentation conditions, strains, cultivation media, a...

    Authors: Yan Guangbo, Shu Min, Shen Wei, Ma Lixin, Zhai Chao, Wang Yaping and Huang Zunxi
    Citation: BMC Biotechnology 2021 21:49

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