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  1. To investigate the effect of low-intensity pulsed ultrasound (LIPUS) combined with lipid microbubbles on the proliferation and bone regeneration of bone marrow mesenchymal stem cells (BMSCs) in poly (lactic-gl...

    Authors: Lin Jin, Jiali Shan, Yanhong Hao, Yingchun Wang and Liping Liu
    Citation: BMC Biotechnology 2023 23:13
  2. Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intesti...

    Authors: Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C. Elfar, Manmeet Rawat and Walaa Elfar
    Citation: BMC Biotechnology 2023 23:12
  3. The western flower thrips Frankliniella occidentalis is an insect pest that damages various crops, including hot peppers. It is a vector of a plant pathogen, tomato spotted wilt virus. To control this pest, chemi...

    Authors: Falguni Khan, Minlee Kim and Yonggyun Kim
    Citation: BMC Biotechnology 2023 23:10
  4. Camptothecin derivatives are one of the most prescribed anticancer drugs for cancer patients, however, the availability, efficiency, and water solubility are the major challenges that halt the applicability of...

    Authors: Nermeen A. Kelany, Ashraf S. A. El-Sayed and Manar A. Ibrahim
    Citation: BMC Biotechnology 2023 23:9
  5. Scaffolds for tissue engineering can be received by whole organ decellularization while maintaining the site-specific extracellular matrix and the vascular tree. One among other decellularization techniques is...

    Authors: Johannes Sauter, Hannes Degenhardt, Jutta Tuebel, Peter Foehr, Philipp Knoeckel, Kira Florian, Fiona Charitou, Rainer Burgkart and Andreas Schmitt
    Citation: BMC Biotechnology 2023 23:8
  6. Mammalian cell lines are frequently used as protein expression hosts because of their ability to correctly fold and assemble complex proteins, produce them at high titers, and confer post-translational modific...

    Authors: Erica A. Green, Nathaniel K. Hamaker and Kelvin H. Lee
    Citation: BMC Biotechnology 2023 23:7
  7. Connective tissue growth factor (CTGF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA) by facilitating angiogenesis and is a promising therapeutic target for RA treatment. Herein, we gene...

    Authors: Yang Qin, Gan Wu, Jiayi Jin, Hao Wang, Jiani Zhang, Li Liu, Heping Zhao, Jianguang Wang and Xinyu Yang
    Citation: BMC Biotechnology 2023 23:6
  8. In industrial microbial biotechnology, fed-batch processes are frequently used to avoid undesirable biological phenomena, such as substrate inhibition or overflow metabolism. For targeted process development, ...

    Authors: Sarah Sparviero, Laura Barth, Timm Keil, Carl Dinter, Christoph Berg, Clemens Lattermann and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:5
  9. Because humans lack α-galactosidase, foods containing certain oligosaccharides from the raffinose family, such as soybeans and other legumes, may disrupt digestion and cause flatulence.

    Authors: Abdelmageed M. Othman, Ali M. Elshafei, Maysa A. Elsayed, Gamil E. Ibrahim, Mohamed M. Hassan and Nayra S. Mehanna
    Citation: BMC Biotechnology 2023 23:3
  10. Rhamnolipids are a group of the extracellular microbial surface-active molecules produced by certain Pseudomonas species with various environmental and industrial applications. The goal of the present research wa...

    Authors: Shima Dabaghi, Seyed Ahmad Ataei and Ali Taheri
    Citation: BMC Biotechnology 2023 23:2
  11. Docosahexaenoic acid (DHA) can improve human and animal health, particularly including anti-inflammatory, antioxidant, anticancer, neurological, and visual functions. Schizochytrium sp. is a marine heterotrophic ...

    Authors: Jun Ding, Zilin Fu, Yingkun Zhu, Junhao He, Lu Ma and Dengpan Bu
    Citation: BMC Biotechnology 2022 22:39
  12. Newcastle disease virus (NDV) strain ZM10, a typical enterotropic avirulent vaccine strain, has been widely used in China for chickens against Newcastle disease. To elucidate its enterotropic mechanism and dev...

    Authors: Lei He, Hairong Wang, Zuhua Yu, Chengshui Liao, Ke Ding, Cai Zhang, Chuan Yu and Chunjie Zhang
    Citation: BMC Biotechnology 2022 22:38
  13. Dead swine carcass composting is an excellent method for harmless treatment and resource utilization of swine carcass. However, poor biodegradation ability of traditional composting results in poor harmless tr...

    Authors: Wei Zhai, Xintian Li, Xinran Duan, Changlong Gou, Lixia Wang and Yunhang Gao
    Citation: BMC Biotechnology 2022 22:36
  14. A mixture of phenol and guanidine isothiocyanate (“P/GI”, the principal components of TRIzol™ and similar products) is routinely used to isolate RNA, DNA, and proteins from a single specimen. In time-course ex...

    Authors: Madeline Snedden, Lavisha Singh, Chandrashekara Kyathanahalli and Emmet Hirsch
    Citation: BMC Biotechnology 2022 22:35
  15. Callus induction is the first step in optimizing plant regeneration. Fit embryogenesis and shooting rely on callus induction. In addition, using artificial intelligence models in combination with an algorithm ...

    Authors: Masoumeh Fallah Ziarani, Masoud Tohidfar and Mohammad Navvabi
    Citation: BMC Biotechnology 2022 22:34
  16. DNA methyltransferases (MTases) are enzymes that induce methylation, one of the representative epigenetic modifications of DNA, and are also useful tools for analyzing epigenomes. However, regarding DNA cytosi...

    Authors: Fumihito Miura, Miki Miura, Yukiko Shibata, Yoshikazu Furuta, Keisuke Miyamura, Yuki Ino, Asmaa M. A. Bayoumi, Utako Oba and Takashi Ito
    Citation: BMC Biotechnology 2022 22:33

    The Correction to this article has been published in BMC Biotechnology 2022 22:37

  17. Leukocyte phytohemagglutinin (PHA-L), derived from the L4 tetramer of PHA, has been frequently employed as a mitogen to induce T lymphocyte proliferation in vitro. The biological application of PHA-L in cancer...

    Authors: Peipei Wang, Junmei Hu, Jiaqi Duan, Shitong Min, Congliang Chen, Yue Zhu, Yan Pan, Yitian Wang, Dapeng Wei and Xia Wang
    Citation: BMC Biotechnology 2022 22:32
  18. Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose r...

    Authors: Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi and Fatemeh Rahimi-Jamnani
    Citation: BMC Biotechnology 2022 22:31
  19. An important conceptual advance in health and the environment has been recognized that enzymes play a key role in the green processing industries. Of particular interest, chitosanase is beneficial for recyclin...

    Authors: Rong-Xian Zhang, Zhong-Wei Wu, Shu-Juan Zhang, Hui-Min Wei, Cheng-Wei Hua, Lan Li and Tian-You Yang
    Citation: BMC Biotechnology 2022 22:30
  20. We aimed to develop a computer-aided detection (CAD) system for accurate identification of benign pigmented skin lesions (PSLs) from images captured using a digital camera or a smart phone.

    Authors: Hui Ding, Eejia Zhang, Fumin Fang, Xing Liu, Huiying Zheng, Hedan Yang, Yiping Ge, Yin Yang and Tong Lin
    Citation: BMC Biotechnology 2022 22:28
  21. Lymphocytic leukemia (LL) is a primary malignant tumor of hematopoietic tissue, which seriously affects the health of children and the elderly. The study aims to establish a new detection method for screening ...

    Authors: Zhen Zhang, Jintao Zhang, Shanshan Dai and Hang Xu
    Citation: BMC Biotechnology 2022 22:27
  22. With the growing concern for the environment, there are trends that bio-utilization of keratinous waste by keratinases could ease the heavy burden of keratinous waste from the poultry processing and leather in...

    Authors: Rong-Xian Zhang, Zhong-Wei Wu, Hai-Yang Cui, Ying-Nan Chai, Cheng-Wei Hua, Peng Wang, Lan Li and Tian-You Yang
    Citation: BMC Biotechnology 2022 22:26
  23. The chicken in ovo model is an attractive system to explore underlying mechanisms of neural and brain development, and it is important to develop effective genetic modification techniques that permit analyses ...

    Authors: Kyung Min Jung, Kyung Je Park, Young Min Kim and Jae Yong Han
    Citation: BMC Biotechnology 2022 22:25
  24. The metabolic engineering of high-biomass crops for lipid production in their vegetative biomass has recently been proposed as a strategy to elevate energy density and lipid yields for biodiesel production. En...

    Authors: Guangbin Luo, Viet Dang Cao, Baskaran Kannan, Hui Liu, John Shanklin and Fredy Altpeter
    Citation: BMC Biotechnology 2022 22:24
  25. Temporomandibular disorder (TMD) refers to a group of disorders that affect temporomandibular joint (TMJ) and its associated muscles with very limited treatment options. Stem cell research is emerging as one o...

    Authors: Vesna Karic, Rahul Chandran and Heidi Abrahamse
    Citation: BMC Biotechnology 2022 22:23
  26. The PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies show that therapeutic antibodies blocking the PD-1 pathway can restore...

    Authors: Sepideh Safaei Ghaderi, Farhad Riazi-Rad, Elmira Safaie Qamsari, Salman Bagheri, Fatemeh Rahimi-Jamnani and Zahra Sharifzadeh
    Citation: BMC Biotechnology 2022 22:22
  27. Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen that causes nosocomial infections and often exhibits antibiotic resistance. Therefore, the development of an accurate method for detecting P. aeruginosa ...

    Authors: Gyu-Min Lim, Joo-Kyung Kim, Eun-Jung Kim, Chang-Soo Lee, Wooseong Kim, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:21
  28. Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal...

    Authors: Dong-Ern Kim, Ji-Hye Lee, Kuk-Bin Ji, Kang-Sun Park, Tae-Young Kil, Okjae Koo and Min-Kyu Kim
    Citation: BMC Biotechnology 2022 22:19
  29. Tetramethylpyrazine (TTMP) is a flavoring additive that significantly contributes to the formation of flavor compounds in soybean-based fermented foods. Over recent years, the application of TTMP in the food i...

    Authors: Zhenli Liu, Yongjun Wu, Lincheng Zhang, Shuoqiu Tong, Jing Jin, Xian Gong and Jie Zhong
    Citation: BMC Biotechnology 2022 22:18
  30. Mass vaccination of dogs as important rabies reservoir is proposed to most effectively reduce and eliminate rabies also in humans. However, a minimum coverage of 70% needs to be achieved for control of the dis...

    Authors: Khaled Trabelsi, Meriem Ben Zakour, Ingo Jordan, Volker Sandig, Samia Rourou and Hela Kallel
    Citation: BMC Biotechnology 2022 22:17
  31. The aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system (SEDDS).

    Authors: Yunhong Wang, Jingcai Chen, Yang Yang, Sijia Gao, Zhuzhu Wang, Yating Liu, Xiaomei Zhang, Lei Hua, Yanlei Guo and Yong Yang
    Citation: BMC Biotechnology 2022 22:16
  32. The discovery of the CRISPR-Cas9 system and its applicability in mammalian embryos has revolutionized the way we generate genetically engineered animal models. To date, models harbouring conditional alleles (i...

    Authors: Guillaume Bernas, Mariette Ouellet, Andréa Barrios, Hélène Jamann, Catherine Larochelle, Émile Lévy and Jean-François Schmouth
    Citation: BMC Biotechnology 2022 22:14
  33. Type I interferons are widely used in research applications and as biotherapeutics. Current assays used to measure interferon concentrations, such as plaque reduction assays and ELISA, are expensive, technical...

    Authors: Michael Puckette, J. Barrera, M. Schwarz and M. Rasmussen
    Citation: BMC Biotechnology 2022 22:13
  34. CRISPR-based programmable transcriptional activators (PTAs) are used in plants for rewiring gene networks. Better tuning of their activity in a time and dose-dependent manner should allow precise control of ge...

    Authors: Elena Garcia-Perez, Borja Diego-Martin, Alfredo Quijano-Rubio, Elena Moreno-Giménez, Sara Selma, Diego Orzaez and Marta Vazquez-Vilar
    Citation: BMC Biotechnology 2022 22:12
  35. Feathers are the most abundant agricultural waste produced by poultry farms. The accumulation of a large number of feathers not only seriously pollutes the environment but also causes the waste of protein reso...

    Authors: Naikun Shen, Mengying Yang, Chenjie Xie, Jiangxin Pan, Kunrong Pang, Hongyan Zhang, Yibing Wang and Mingguo Jiang
    Citation: BMC Biotechnology 2022 22:11
  36. Site-directed mutagenesis (SDM) is a key method in molecular biology; allowing to modify DNA sequences at single base pair resolution. Although many SDM methods have been developed, methods that increase effic...

    Authors: Shunit Olszakier and Shai Berlin
    Citation: BMC Biotechnology 2022 22:10
  37. Antrodia cinnamomea, a rare medicinal fungus, has been increasingly studied in recent years because of its abundant secondary metabolites which are beneficial to humans. However, there is a lack of research on it...

    Authors: JianZhi Chu, YongFei Ming, Qi Cui, Na Zheng, ShuDe Yang, WeiHuan Li, Hongwei Gao, Rui Zhang and XianHao Cheng
    Citation: BMC Biotechnology 2022 22:9
  38. Human matrix metalloproteinase 9 (hMMP9) is a biomarker in several diseases, including cancer, and the need for developing detectors and inhibitors of hMMP9 is increasing. As an antibody against hMMP9 can be s...

    Authors: Jina Ryu, Eun-Jung Kim, Joo-Kyung Kim, Tai Hyun Park, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:8
  39. One-step fermentation is a cheap way to produce xylo-oligosaccharides (XOS), where production of xylanases and XOS is integrated into a single process. In spite of cost advantage, one-step fermentation is stil...

    Authors: Jiawen Liu, Cong Liu, Shilei Qiao, Zhen Dong, Di Sun, Jingrong Zhu and Weijie Liu
    Citation: BMC Biotechnology 2022 22:6
  40. The fall armyworm, Spodoptera frugiperda, is a significant and widespread pest of maize, sorghum, rice, and other economically important crops. Successful management of this caterpillar pest has historically reli...

    Authors: Catherine E. Reavey, Adam S. Walker, Stephen P. Joyce, Lucy Broom, Alan Willse, Kyla Ercit, Mattia Poletto, Zoe H. Barnes, Thea Marubbi, Bartlomiej J. Troczka, David Treanor, Katherine Beadle, Ben Granville, Vanessa de Mello, Joss Teal, Edward Sulston…
    Citation: BMC Biotechnology 2022 22:5
  41. Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment. Thus, replacement of petroleum-based materials with new and effective renewable...

    Authors: Piwu Li, Fei Zhao, Xiaofeng Wei, Xiangling Tao and Feng Ding
    Citation: BMC Biotechnology 2022 22:4
  42. The present study intends to optimize the processing technology for the wine-processing of Rhizoma Coptidis, using alkaloids as indicators.

    Authors: Yunhong Wang, Weihan Qin, Yujie Yang, Hui Bai, Jirui Wang, Xiaomei Zhang, Yanlei Guo, Lei Hua and Yong Yang
    Citation: BMC Biotechnology 2022 22:3

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