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  1. One critical parameter in microbial cultivations is the composition of the cultivation medium. Nowadays, the application of chemically defined media increases, due to a more defined and reproducible fermentati...

    Authors: Jennifer Goldmanns, Georg Andreas Röhling, Marie Kristine Lipa, Theresa Scholand, Alexander Deitert, Tobias May, Evangeline Priya Haas, Matthias Boy, Andrea Herold and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:25
  2. Infectious diseases prompted by micro-organisms such as fungi, parasites, or microbes, have influenced many countries’ public health causing death. Scientists declared that metal oxide composites have various ...

    Authors: Elsayed Elgazzar, H. A. Ayoub, Z. A. El-Wahab and Wageha A. Mostafa
    Citation: BMC Biotechnology 2023 23:23
  3. L-lysine is widely used for feed and special diet products. The transformation of fermentation strains plays a decisive role in the development of these industries. Based on the mutation breeding theory and me...

    Authors: Nan Li, Jie Lu, Zirui Wang, Peng Du, Piwu Li, Jing Su, Jing Xiao, Min Wang, Junqing Wang and Ruiming Wang
    Citation: BMC Biotechnology 2023 23:22
  4. Gelatin methacrylate-based hydrogels (GelMA) were widely used in tissue engineering and regenerative medicine. However, to manipulate their various chemical and physical properties and create high-efficiency h...

    Authors: Nahideh Asadi, Hadi Sadeghzadeh, Azizeh Rahmani Del Bakhshayesh, Amir Nezami Asl, Mehdi Dadashpour, Negar Karimi Hajishoreh, Sharif Kaamyabi and Abolfazl Akbarzadeh
    Citation: BMC Biotechnology 2023 23:21
  5. The current study is focused on the lipid extract of microalgae; Pectinodesmus strain PHM3 and its general analysis in terms of chemical contents. Combinations of both chemical and mechanistic approaches were app...

    Authors: Dania Akram Kiyani, Shafia Maryam, Sundus Jabeen Amina, Abdullah Ahmad, Muhammad Waqas Alam Chattha and Hussnain Ahmed Janjua
    Citation: BMC Biotechnology 2023 23:20
  6. The thermophilic fungus Chaetomium thermophilum has been used extensively for biochemical and high-resolution structural studies of protein complexes. However, subsequent functional analyses of these assemblies h...

    Authors: Sven Reislöhner, Geza Schermann, Max Kilian, Daniela Santamaría-Muñoz, Christian Zimmerli, Nikola Kellner, Jochen Baßler, Michael Brunner and Ed Hurt
    Citation: BMC Biotechnology 2023 23:19
  7. Plastic pollution is a major global concern to the health and wellbeing of all terrestrial and marine life. However, no sustainable method for waste management is currently viable. This study addresses the opt...

    Authors: Michael Gollan, Gary Black and Jose Munoz-Munoz
    Citation: BMC Biotechnology 2023 23:18
  8. The invasive and calamitous polyphagous pest Spodoptera frugiperda or commonly known as fall armyworm (FAW) poses serious menace to the global agricultural production. Owing to the revamped invasion of FAW in 201...

    Authors: Snigdha Samanta, Mritunjoy Barman, Himanshu Thakur, Swati Chakraborty, Gouranga Upadhyaya, Deepayan Roy, Amitava Banerjee, Arunava Samanta and Jayanta Tarafdar
    Citation: BMC Biotechnology 2023 23:17
  9. Currently, broad industrial application of laccases is commonly restricted by the high-cost related production. Solid state fermentation (SSF) using agricultural waste is an attractively economic strategy for ...

    Authors: Lulu Wang, Ni An, Junting Gao, Huiting Xue and Guanhua Li
    Citation: BMC Biotechnology 2023 23:16
  10. The interleukin-1 receptor antagonist (IL-1Ra) is a crucial molecule that counteracts the effects of interleukin-1 (IL-1) by binding to its receptor. A high concentration of IL-1Ra is required for complete inh...

    Authors: Lena Mahmoudi Azar, Elif Karaman, Burcu Beyaz, Işılay Göktan, Alp Ertunga Eyüpoğlu, Seda Kizilel, Batu Erman, Ahmet Gül and Serdar Uysal
    Citation: BMC Biotechnology 2023 23:15
  11. Large-scale transient expression of recombinant proteins in plants is increasingly used and requires the multi-liter cultivation of Agrobacterium tumefaciens transformed with an expression vector, which is often ...

    Authors: Matthias Knödler, Paul Winman Reunious and Johannes Felix Buyel
    Citation: BMC Biotechnology 2023 23:14
  12. To investigate the effect of low-intensity pulsed ultrasound (LIPUS) combined with lipid microbubbles on the proliferation and bone regeneration of bone marrow mesenchymal stem cells (BMSCs) in poly (lactic-gl...

    Authors: Lin Jin, Jiali Shan, Yanhong Hao, Yingchun Wang and Liping Liu
    Citation: BMC Biotechnology 2023 23:13
  13. Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intesti...

    Authors: Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C. Elfar, Manmeet Rawat and Walaa Elfar
    Citation: BMC Biotechnology 2023 23:12
  14. The western flower thrips Frankliniella occidentalis is an insect pest that damages various crops, including hot peppers. It is a vector of a plant pathogen, tomato spotted wilt virus. To control this pest, chemi...

    Authors: Falguni Khan, Minlee Kim and Yonggyun Kim
    Citation: BMC Biotechnology 2023 23:10
  15. Camptothecin derivatives are one of the most prescribed anticancer drugs for cancer patients, however, the availability, efficiency, and water solubility are the major challenges that halt the applicability of...

    Authors: Nermeen A. Kelany, Ashraf S. A. El-Sayed and Manar A. Ibrahim
    Citation: BMC Biotechnology 2023 23:9
  16. Scaffolds for tissue engineering can be received by whole organ decellularization while maintaining the site-specific extracellular matrix and the vascular tree. One among other decellularization techniques is...

    Authors: Johannes Sauter, Hannes Degenhardt, Jutta Tuebel, Peter Foehr, Philipp Knoeckel, Kira Florian, Fiona Charitou, Rainer Burgkart and Andreas Schmitt
    Citation: BMC Biotechnology 2023 23:8
  17. Mammalian cell lines are frequently used as protein expression hosts because of their ability to correctly fold and assemble complex proteins, produce them at high titers, and confer post-translational modific...

    Authors: Erica A. Green, Nathaniel K. Hamaker and Kelvin H. Lee
    Citation: BMC Biotechnology 2023 23:7
  18. Connective tissue growth factor (CTGF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA) by facilitating angiogenesis and is a promising therapeutic target for RA treatment. Herein, we gene...

    Authors: Yang Qin, Gan Wu, Jiayi Jin, Hao Wang, Jiani Zhang, Li Liu, Heping Zhao, Jianguang Wang and Xinyu Yang
    Citation: BMC Biotechnology 2023 23:6
  19. In industrial microbial biotechnology, fed-batch processes are frequently used to avoid undesirable biological phenomena, such as substrate inhibition or overflow metabolism. For targeted process development, ...

    Authors: Sarah Sparviero, Laura Barth, Timm Keil, Carl Dinter, Christoph Berg, Clemens Lattermann and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:5
  20. Because humans lack α-galactosidase, foods containing certain oligosaccharides from the raffinose family, such as soybeans and other legumes, may disrupt digestion and cause flatulence.

    Authors: Abdelmageed M. Othman, Ali M. Elshafei, Maysa A. Elsayed, Gamil E. Ibrahim, Mohamed M. Hassan and Nayra S. Mehanna
    Citation: BMC Biotechnology 2023 23:3
  21. Rhamnolipids are a group of the extracellular microbial surface-active molecules produced by certain Pseudomonas species with various environmental and industrial applications. The goal of the present research wa...

    Authors: Shima Dabaghi, Seyed Ahmad Ataei and Ali Taheri
    Citation: BMC Biotechnology 2023 23:2
  22. Docosahexaenoic acid (DHA) can improve human and animal health, particularly including anti-inflammatory, antioxidant, anticancer, neurological, and visual functions. Schizochytrium sp. is a marine heterotrophic ...

    Authors: Jun Ding, Zilin Fu, Yingkun Zhu, Junhao He, Lu Ma and Dengpan Bu
    Citation: BMC Biotechnology 2022 22:39
  23. Newcastle disease virus (NDV) strain ZM10, a typical enterotropic avirulent vaccine strain, has been widely used in China for chickens against Newcastle disease. To elucidate its enterotropic mechanism and dev...

    Authors: Lei He, Hairong Wang, Zuhua Yu, Chengshui Liao, Ke Ding, Cai Zhang, Chuan Yu and Chunjie Zhang
    Citation: BMC Biotechnology 2022 22:38
  24. Dead swine carcass composting is an excellent method for harmless treatment and resource utilization of swine carcass. However, poor biodegradation ability of traditional composting results in poor harmless tr...

    Authors: Wei Zhai, Xintian Li, Xinran Duan, Changlong Gou, Lixia Wang and Yunhang Gao
    Citation: BMC Biotechnology 2022 22:36
  25. A mixture of phenol and guanidine isothiocyanate (“P/GI”, the principal components of TRIzol™ and similar products) is routinely used to isolate RNA, DNA, and proteins from a single specimen. In time-course ex...

    Authors: Madeline Snedden, Lavisha Singh, Chandrashekara Kyathanahalli and Emmet Hirsch
    Citation: BMC Biotechnology 2022 22:35
  26. Callus induction is the first step in optimizing plant regeneration. Fit embryogenesis and shooting rely on callus induction. In addition, using artificial intelligence models in combination with an algorithm ...

    Authors: Masoumeh Fallah Ziarani, Masoud Tohidfar and Mohammad Navvabi
    Citation: BMC Biotechnology 2022 22:34
  27. DNA methyltransferases (MTases) are enzymes that induce methylation, one of the representative epigenetic modifications of DNA, and are also useful tools for analyzing epigenomes. However, regarding DNA cytosi...

    Authors: Fumihito Miura, Miki Miura, Yukiko Shibata, Yoshikazu Furuta, Keisuke Miyamura, Yuki Ino, Asmaa M. A. Bayoumi, Utako Oba and Takashi Ito
    Citation: BMC Biotechnology 2022 22:33

    The Correction to this article has been published in BMC Biotechnology 2022 22:37

  28. Leukocyte phytohemagglutinin (PHA-L), derived from the L4 tetramer of PHA, has been frequently employed as a mitogen to induce T lymphocyte proliferation in vitro. The biological application of PHA-L in cancer...

    Authors: Peipei Wang, Junmei Hu, Jiaqi Duan, Shitong Min, Congliang Chen, Yue Zhu, Yan Pan, Yitian Wang, Dapeng Wei and Xia Wang
    Citation: BMC Biotechnology 2022 22:32
  29. Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose r...

    Authors: Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi and Fatemeh Rahimi-Jamnani
    Citation: BMC Biotechnology 2022 22:31
  30. An important conceptual advance in health and the environment has been recognized that enzymes play a key role in the green processing industries. Of particular interest, chitosanase is beneficial for recyclin...

    Authors: Rong-Xian Zhang, Zhong-Wei Wu, Shu-Juan Zhang, Hui-Min Wei, Cheng-Wei Hua, Lan Li and Tian-You Yang
    Citation: BMC Biotechnology 2022 22:30
  31. We aimed to develop a computer-aided detection (CAD) system for accurate identification of benign pigmented skin lesions (PSLs) from images captured using a digital camera or a smart phone.

    Authors: Hui Ding, Eejia Zhang, Fumin Fang, Xing Liu, Huiying Zheng, Hedan Yang, Yiping Ge, Yin Yang and Tong Lin
    Citation: BMC Biotechnology 2022 22:28
  32. Lymphocytic leukemia (LL) is a primary malignant tumor of hematopoietic tissue, which seriously affects the health of children and the elderly. The study aims to establish a new detection method for screening ...

    Authors: Zhen Zhang, Jintao Zhang, Shanshan Dai and Hang Xu
    Citation: BMC Biotechnology 2022 22:27
  33. With the growing concern for the environment, there are trends that bio-utilization of keratinous waste by keratinases could ease the heavy burden of keratinous waste from the poultry processing and leather in...

    Authors: Rong-Xian Zhang, Zhong-Wei Wu, Hai-Yang Cui, Ying-Nan Chai, Cheng-Wei Hua, Peng Wang, Lan Li and Tian-You Yang
    Citation: BMC Biotechnology 2022 22:26
  34. The chicken in ovo model is an attractive system to explore underlying mechanisms of neural and brain development, and it is important to develop effective genetic modification techniques that permit analyses ...

    Authors: Kyung Min Jung, Kyung Je Park, Young Min Kim and Jae Yong Han
    Citation: BMC Biotechnology 2022 22:25
  35. The metabolic engineering of high-biomass crops for lipid production in their vegetative biomass has recently been proposed as a strategy to elevate energy density and lipid yields for biodiesel production. En...

    Authors: Guangbin Luo, Viet Dang Cao, Baskaran Kannan, Hui Liu, John Shanklin and Fredy Altpeter
    Citation: BMC Biotechnology 2022 22:24
  36. Temporomandibular disorder (TMD) refers to a group of disorders that affect temporomandibular joint (TMJ) and its associated muscles with very limited treatment options. Stem cell research is emerging as one o...

    Authors: Vesna Karic, Rahul Chandran and Heidi Abrahamse
    Citation: BMC Biotechnology 2022 22:23
  37. The PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies show that therapeutic antibodies blocking the PD-1 pathway can restore...

    Authors: Sepideh Safaei Ghaderi, Farhad Riazi-Rad, Elmira Safaie Qamsari, Salman Bagheri, Fatemeh Rahimi-Jamnani and Zahra Sharifzadeh
    Citation: BMC Biotechnology 2022 22:22
  38. Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen that causes nosocomial infections and often exhibits antibiotic resistance. Therefore, the development of an accurate method for detecting P. aeruginosa ...

    Authors: Gyu-Min Lim, Joo-Kyung Kim, Eun-Jung Kim, Chang-Soo Lee, Wooseong Kim, Byung-Gee Kim and Hee-Jin Jeong
    Citation: BMC Biotechnology 2022 22:21
  39. Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal...

    Authors: Dong-Ern Kim, Ji-Hye Lee, Kuk-Bin Ji, Kang-Sun Park, Tae-Young Kil, Okjae Koo and Min-Kyu Kim
    Citation: BMC Biotechnology 2022 22:19
  40. Tetramethylpyrazine (TTMP) is a flavoring additive that significantly contributes to the formation of flavor compounds in soybean-based fermented foods. Over recent years, the application of TTMP in the food i...

    Authors: Zhenli Liu, Yongjun Wu, Lincheng Zhang, Shuoqiu Tong, Jing Jin, Xian Gong and Jie Zhong
    Citation: BMC Biotechnology 2022 22:18
  41. Mass vaccination of dogs as important rabies reservoir is proposed to most effectively reduce and eliminate rabies also in humans. However, a minimum coverage of 70% needs to be achieved for control of the dis...

    Authors: Khaled Trabelsi, Meriem Ben Zakour, Ingo Jordan, Volker Sandig, Samia Rourou and Hela Kallel
    Citation: BMC Biotechnology 2022 22:17
  42. The aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system (SEDDS).

    Authors: Yunhong Wang, Jingcai Chen, Yang Yang, Sijia Gao, Zhuzhu Wang, Yating Liu, Xiaomei Zhang, Lei Hua, Yanlei Guo and Yong Yang
    Citation: BMC Biotechnology 2022 22:16
  43. The discovery of the CRISPR-Cas9 system and its applicability in mammalian embryos has revolutionized the way we generate genetically engineered animal models. To date, models harbouring conditional alleles (i...

    Authors: Guillaume Bernas, Mariette Ouellet, Andréa Barrios, Hélène Jamann, Catherine Larochelle, Émile Lévy and Jean-François Schmouth
    Citation: BMC Biotechnology 2022 22:14

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