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  1. Brucellosis remains one of the global health concerns that reemerges in recent years. Delayed or inaccurate diagnosis end to a long treatment duration and financial burden; therefore, finding a good antigen fo...

    Authors: M. Golchin, S. Mollayi, E. Mohammadi and N. Eskandarzade
    Citation: BMC Biotechnology 2023 23:46
  2. Target identification is an essential part of the drug discovery and development process, and its efficacy plays a crucial role in the success of any given therapy. Although protein target identification resea...

    Authors: Yasser Tabana, Dinesh Babu, Richard Fahlman, Arno G. Siraki and Khaled Barakat
    Citation: BMC Biotechnology 2023 23:44
  3. The major safety concern of the clinical application of wild type FGF19 (FGF19WT) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 varian...

    Authors: Lu Shi, Tiantian Zhao, Lei Huang, Xiaomin Pan, Tianzhen Wu, Xin Feng, Taoli Chen, Jiamin Wu and Jianlou Niu
    Citation: BMC Biotechnology 2023 23:43
  4. Helicobacter pylori cause a variety of gastric malignancies, gastric ulcers, and cause erosive diseases. The extreme nature of the bacterium and the implantation of this bacterium protects it against designing a ...

    Authors: Zahra Ahmadzadeh Chaleshtori, Ali Asghar Rastegari, Hashem Nayeri and Abbas Doosti
    Citation: BMC Biotechnology 2023 23:42
  5. Metal nanoparticles exhibit excellent antifungal abilities and are seen as a good substitute for controlling different kinds of fungi. Of all known taxa, cyanobacteria have received significant consideration a...

    Authors: Bahareh Nowruzi, Bilal Saad Jalil and James S Metcalf
    Citation: BMC Biotechnology 2023 23:41
  6. Cutaneotrichosporon oleaginosus is an oleaginous yeast that can produce up to 80% lipid per dry weight. Its high capacity for the biosynthesis of single cell oil makes it highly interesting for the production of ...

    Authors: Nikolaus I. Stellner, Zora S. Rerop, Norbert Mehlmer, Mahmoud Masri, Marion Ringel and Thomas B. Brück
    Citation: BMC Biotechnology 2023 23:40
  7. Staphylococcus aureus is a unique challenge for the healthcare system because it can form biofilms, is resistant to the host's immune system, and is resistant to numerous antimicrobial therapies. The aim of this ...

    Authors: Ellahe Nouruzi, Seyed Mostafa Hosseini, Babak Asghari, Reza Mahjoub, Ehsan Nazarzadeh Zare, Mohammad-Ali Shahbazi, Fereshte Kalhori and Mohammad Reza Arabestani
    Citation: BMC Biotechnology 2023 23:39
  8. Cartilage defects are common sports injuries without significant treatment. Articular cartilage with inferior regenerative potential resulted in the poor formation of hyaline cartilage in defects. Acellular ma...

    Authors: Huiming Jiang, Jun Lu, Jiawei Li, Zizheng Liu, Fufei Chen, Rui Wu, Xingquan Xu, Yuan Liu, Yiqiu Jiang and Dongquan Shi
    Citation: BMC Biotechnology 2023 23:38
  9. Classical swine fever (CSF) is a fatal contagious disease affecting pigs caused by classical swine fever virus (CSFV). The disease can be transmitted by pigs and wild boars, and it is difficult to prevent and ...

    Authors: Riai Okamoto, Nobumasa Ito, Yutaro Ide, Bouchra Kitab, Yoshihiro Sakoda and Kyoko Tsukiyama-Kohara
    Citation: BMC Biotechnology 2023 23:37
  10. Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients. This study was conducted to quantify and compare the solubility ...

    Authors: Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco and Xavier Declèves
    Citation: BMC Biotechnology 2023 23:36
  11. Biofuel research that aims to optimize growth conditions in microalgae is critically important. Chlamydomonas reinhardtii is a green microalga that offers advantages for biofuel production research. This study co...

    Authors: David I. Gonzalez and Ruby A. Ynalvez
    Citation: BMC Biotechnology 2023 23:35
  12. Currently, Aspergillus terreus is used for the industrial production of itaconic acid. Although, alternative feedstock use in fermentations is crucial for cost-efficient and sustainable itaconic acid production, ...

    Authors: Paul-Joachim Niehoff, Waldemar Müller, Johannes Pastoors, Katharina Miebach, Philipp Ernst, Johannes Hemmerich, Stephan Noack, Nick Wierckx and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:34
  13. Dopamine is high-value compound of pharmaceutical interest, but its industrial scale production mostly focuses on chemical synthesis, possessing environment pollution. Bio-manufacturing has caused much attenti...

    Authors: Siyuan Gao, Ding Ma, Yongtao Wang, Alei Zhang, Xin Wang and Kequan Chen
    Citation: BMC Biotechnology 2023 23:33
  14. Global efforts to characterize diseases of poverty are hampered by lack of affordable and comprehensive detection platforms, resulting in suboptimal allocation of health care resources and inefficient disease ...

    Authors: Iván Hernández-Neuta, Anastasia Magoulopoulou, Flor Pineiro, Jan Gorm Lisby, Mats Gulberg and Mats Nilsson
    Citation: BMC Biotechnology 2023 23:31
  15. Carbohydrate antigen 724 (CA724) is a sensitive and specific indicator for multiple malignant tumors. The aim of this study was to establish a Eu-time resolved fluorescence immunochromatography (Eu-TRFICO) met...

    Authors: Chang Liu, Cuicui Chen, Fenglan Peng, Huankun Liang, Shuhai Zhong, Tiancai Liu, Laiqing Li, Alexander Boronin and Wenqi Dong
    Citation: BMC Biotechnology 2023 23:30
  16. Porcine fetal fibroblasts (PFFs) are important donor cells for generating genetically modified pigs, but the transfection efficiencies of PFFs are often unsatisfactory especially when large-size vectors are to...

    Authors: Weiwei Liu, Xiaoguo Wang, Ruirong Liu, Yaya Liao, Zhiwei Peng, Haoyun Jiang, Qiqi Jing and Yuyun Xing
    Citation: BMC Biotechnology 2023 23:29
  17. Coelomic fluid, a pharmacologically active compound in earthworms, exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anticancer. However, the biological activities exerte...

    Authors: Asmaa E. Farouk, Sohair R. Fahmy, Amel M. Soliman, Sherif Abdelaziz Ibrahim and Shimaa A. Sadek
    Citation: BMC Biotechnology 2023 23:28
  18. Optimization of indirect shoot regeneration protocols is one of the key prerequisites for the development of Agrobacterium-mediated genetic transformation and/or genome editing in Passiflora caerulea. Comprehensi...

    Authors: Marziyeh Jafari and Mohammad Hosein Daneshvar
    Citation: BMC Biotechnology 2023 23:27
  19. Oxford Nanopore sequencing technology (ONT) is currently widely used due to its affordability, simplicity, and reliability. Despite the advantage ONT has over next-generation sequencing in detecting resistance...

    Authors: Hussain A. Safar, Fatemah Alatar, Kother Nasser, Rehab Al-Ajmi, Wadha Alfouzan and Abu Salim Mustafa
    Citation: BMC Biotechnology 2023 23:26
  20. One critical parameter in microbial cultivations is the composition of the cultivation medium. Nowadays, the application of chemically defined media increases, due to a more defined and reproducible fermentati...

    Authors: Jennifer Goldmanns, Georg Andreas Röhling, Marie Kristine Lipa, Theresa Scholand, Alexander Deitert, Tobias May, Evangeline Priya Haas, Matthias Boy, Andrea Herold and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:25
  21. Infectious diseases prompted by micro-organisms such as fungi, parasites, or microbes, have influenced many countries’ public health causing death. Scientists declared that metal oxide composites have various ...

    Authors: Elsayed Elgazzar, H. A. Ayoub, Z. A. El-Wahab and Wageha A. Mostafa
    Citation: BMC Biotechnology 2023 23:23
  22. L-lysine is widely used for feed and special diet products. The transformation of fermentation strains plays a decisive role in the development of these industries. Based on the mutation breeding theory and me...

    Authors: Nan Li, Jie Lu, Zirui Wang, Peng Du, Piwu Li, Jing Su, Jing Xiao, Min Wang, Junqing Wang and Ruiming Wang
    Citation: BMC Biotechnology 2023 23:22
  23. Gelatin methacrylate-based hydrogels (GelMA) were widely used in tissue engineering and regenerative medicine. However, to manipulate their various chemical and physical properties and create high-efficiency h...

    Authors: Nahideh Asadi, Hadi Sadeghzadeh, Azizeh Rahmani Del Bakhshayesh, Amir Nezami Asl, Mehdi Dadashpour, Negar Karimi Hajishoreh, Sharif Kaamyabi and Abolfazl Akbarzadeh
    Citation: BMC Biotechnology 2023 23:21
  24. The current study is focused on the lipid extract of microalgae; Pectinodesmus strain PHM3 and its general analysis in terms of chemical contents. Combinations of both chemical and mechanistic approaches were app...

    Authors: Dania Akram Kiyani, Shafia Maryam, Sundus Jabeen Amina, Abdullah Ahmad, Muhammad Waqas Alam Chattha and Hussnain Ahmed Janjua
    Citation: BMC Biotechnology 2023 23:20
  25. The thermophilic fungus Chaetomium thermophilum has been used extensively for biochemical and high-resolution structural studies of protein complexes. However, subsequent functional analyses of these assemblies h...

    Authors: Sven Reislöhner, Geza Schermann, Max Kilian, Daniela Santamaría-Muñoz, Christian Zimmerli, Nikola Kellner, Jochen Baßler, Michael Brunner and Ed Hurt
    Citation: BMC Biotechnology 2023 23:19
  26. Plastic pollution is a major global concern to the health and wellbeing of all terrestrial and marine life. However, no sustainable method for waste management is currently viable. This study addresses the opt...

    Authors: Michael Gollan, Gary Black and Jose Munoz-Munoz
    Citation: BMC Biotechnology 2023 23:18
  27. The invasive and calamitous polyphagous pest Spodoptera frugiperda or commonly known as fall armyworm (FAW) poses serious menace to the global agricultural production. Owing to the revamped invasion of FAW in 201...

    Authors: Snigdha Samanta, Mritunjoy Barman, Himanshu Thakur, Swati Chakraborty, Gouranga Upadhyaya, Deepayan Roy, Amitava Banerjee, Arunava Samanta and Jayanta Tarafdar
    Citation: BMC Biotechnology 2023 23:17
  28. Currently, broad industrial application of laccases is commonly restricted by the high-cost related production. Solid state fermentation (SSF) using agricultural waste is an attractively economic strategy for ...

    Authors: Lulu Wang, Ni An, Junting Gao, Huiting Xue and Guanhua Li
    Citation: BMC Biotechnology 2023 23:16
  29. The interleukin-1 receptor antagonist (IL-1Ra) is a crucial molecule that counteracts the effects of interleukin-1 (IL-1) by binding to its receptor. A high concentration of IL-1Ra is required for complete inh...

    Authors: Lena Mahmoudi Azar, Elif Karaman, Burcu Beyaz, Işılay Göktan, Alp Ertunga Eyüpoğlu, Seda Kizilel, Batu Erman, Ahmet Gül and Serdar Uysal
    Citation: BMC Biotechnology 2023 23:15
  30. Large-scale transient expression of recombinant proteins in plants is increasingly used and requires the multi-liter cultivation of Agrobacterium tumefaciens transformed with an expression vector, which is often ...

    Authors: Matthias Knödler, Paul Winman Reunious and Johannes Felix Buyel
    Citation: BMC Biotechnology 2023 23:14
  31. To investigate the effect of low-intensity pulsed ultrasound (LIPUS) combined with lipid microbubbles on the proliferation and bone regeneration of bone marrow mesenchymal stem cells (BMSCs) in poly (lactic-gl...

    Authors: Lin Jin, Jiali Shan, Yanhong Hao, Yingchun Wang and Liping Liu
    Citation: BMC Biotechnology 2023 23:13
  32. Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intesti...

    Authors: Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C. Elfar, Manmeet Rawat and Walaa Elfar
    Citation: BMC Biotechnology 2023 23:12
  33. The western flower thrips Frankliniella occidentalis is an insect pest that damages various crops, including hot peppers. It is a vector of a plant pathogen, tomato spotted wilt virus. To control this pest, chemi...

    Authors: Falguni Khan, Minlee Kim and Yonggyun Kim
    Citation: BMC Biotechnology 2023 23:10
  34. Camptothecin derivatives are one of the most prescribed anticancer drugs for cancer patients, however, the availability, efficiency, and water solubility are the major challenges that halt the applicability of...

    Authors: Nermeen A. Kelany, Ashraf S. A. El-Sayed and Manar A. Ibrahim
    Citation: BMC Biotechnology 2023 23:9
  35. Scaffolds for tissue engineering can be received by whole organ decellularization while maintaining the site-specific extracellular matrix and the vascular tree. One among other decellularization techniques is...

    Authors: Johannes Sauter, Hannes Degenhardt, Jutta Tuebel, Peter Foehr, Philipp Knoeckel, Kira Florian, Fiona Charitou, Rainer Burgkart and Andreas Schmitt
    Citation: BMC Biotechnology 2023 23:8
  36. Mammalian cell lines are frequently used as protein expression hosts because of their ability to correctly fold and assemble complex proteins, produce them at high titers, and confer post-translational modific...

    Authors: Erica A. Green, Nathaniel K. Hamaker and Kelvin H. Lee
    Citation: BMC Biotechnology 2023 23:7
  37. Connective tissue growth factor (CTGF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA) by facilitating angiogenesis and is a promising therapeutic target for RA treatment. Herein, we gene...

    Authors: Yang Qin, Gan Wu, Jiayi Jin, Hao Wang, Jiani Zhang, Li Liu, Heping Zhao, Jianguang Wang and Xinyu Yang
    Citation: BMC Biotechnology 2023 23:6
  38. In industrial microbial biotechnology, fed-batch processes are frequently used to avoid undesirable biological phenomena, such as substrate inhibition or overflow metabolism. For targeted process development, ...

    Authors: Sarah Sparviero, Laura Barth, Timm Keil, Carl Dinter, Christoph Berg, Clemens Lattermann and Jochen Büchs
    Citation: BMC Biotechnology 2023 23:5
  39. Because humans lack α-galactosidase, foods containing certain oligosaccharides from the raffinose family, such as soybeans and other legumes, may disrupt digestion and cause flatulence.

    Authors: Abdelmageed M. Othman, Ali M. Elshafei, Maysa A. Elsayed, Gamil E. Ibrahim, Mohamed M. Hassan and Nayra S. Mehanna
    Citation: BMC Biotechnology 2023 23:3
  40. Rhamnolipids are a group of the extracellular microbial surface-active molecules produced by certain Pseudomonas species with various environmental and industrial applications. The goal of the present research wa...

    Authors: Shima Dabaghi, Seyed Ahmad Ataei and Ali Taheri
    Citation: BMC Biotechnology 2023 23:2
  41. Docosahexaenoic acid (DHA) can improve human and animal health, particularly including anti-inflammatory, antioxidant, anticancer, neurological, and visual functions. Schizochytrium sp. is a marine heterotrophic ...

    Authors: Jun Ding, Zilin Fu, Yingkun Zhu, Junhao He, Lu Ma and Dengpan Bu
    Citation: BMC Biotechnology 2022 22:39
  42. Newcastle disease virus (NDV) strain ZM10, a typical enterotropic avirulent vaccine strain, has been widely used in China for chickens against Newcastle disease. To elucidate its enterotropic mechanism and dev...

    Authors: Lei He, Hairong Wang, Zuhua Yu, Chengshui Liao, Ke Ding, Cai Zhang, Chuan Yu and Chunjie Zhang
    Citation: BMC Biotechnology 2022 22:38
  43. Dead swine carcass composting is an excellent method for harmless treatment and resource utilization of swine carcass. However, poor biodegradation ability of traditional composting results in poor harmless tr...

    Authors: Wei Zhai, Xintian Li, Xinran Duan, Changlong Gou, Lixia Wang and Yunhang Gao
    Citation: BMC Biotechnology 2022 22:36

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