Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM: Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA. 1997, 94: 10833-10837. 10.1073/pnas.94.20.10833.
Article
CAS
Google Scholar
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S: A Toll-like receptor recognizes bacterial DNA. Nature. 2000, 408: 740-745. 10.1038/35047123.
Article
CAS
Google Scholar
Takeshita F, Leifer CA, Gursel I, Ishii KJ, Takeshita S, Gursel M, Klinman DM: Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol. 2001, 167: 3555-3558.
Article
CAS
Google Scholar
Krieg AM: CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 2002, 20: 709-760. 10.1146/annurev.immunol.20.100301.064842.
Article
CAS
Google Scholar
Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugiu FS, De Carli M, Ricci M, Romagnani S: Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol. 1992, 148: 2142-2147.
CAS
Google Scholar
Trinchieri G: Immunobiology of interleukin-12. Immunol Res. 1998, 17: 269-278. 10.1007/BF02786451.
Article
CAS
Google Scholar
Jahrsdörfer B, Weiner GJ: CpG oligodeoxynucleotides for immune stimulation in cancer immunotherapy. Curr Opin Investig Drugs. 2003, 4: 686-690.
Google Scholar
Fonseca DE, Kline JN: Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev. 2009, 61: 256-262. 10.1016/j.addr.2008.12.007.
Article
CAS
Google Scholar
Klinman DM, Klaschik S, Sato T, Tross D: CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Adv Drug Deliv Rev. 2009, 61: 248-255. 10.1016/j.addr.2008.12.012.
Article
CAS
Google Scholar
Vollmer J, Krieg AM: Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev. 2009, 61: 195-204. 10.1016/j.addr.2008.12.008.
Article
CAS
Google Scholar
Krug A, Rothenfusser S, Hornung V, Jahrsdörfer B, Blackwell S, Ballas ZK, Endres S, Krieg AM, Hartmann G: Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur J Immunol. 2001, 31: 2154-2163. 10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U.
Article
CAS
Google Scholar
Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM: CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995, 374: 546-549. 10.1038/374546a0.
Article
CAS
Google Scholar
Hartmann G, Weeratna RD, Ballas ZK, Payette P, Blackwell S, Suparto I, Rasmussen WL, Waldschmidt M, Sajuthi D, Purcell RH, Davis HL, Krieg AM: Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J Immunol. 2000, 164: 1617-1624.
Article
CAS
Google Scholar
Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, Lubenow N, Rothenfusser S, Endres S: Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells. Eur J Immunol. 2003, 33: 1633-1641. 10.1002/eji.200323813.
Article
CAS
Google Scholar
Samulowitz U, Weber M, Weeratna R, Uhlmann E, Noll B, Krieg AM, Vollmer J: A novel class of immune-stimulatory CpG oligodeoxynucleotides unifies high potency in type I interferon induction with preferred structural properties. Oligonucleotides. 2010, 20: 93-101. 10.1089/oli.2009.0210.
Article
CAS
Google Scholar
Kurreck J: Antisense technologies: Improvement through novel chemical modifications. Eur J Biochem. 2003, 270: 1628-1644. 10.1046/j.1432-1033.2003.03555.x.
Article
CAS
Google Scholar
Agrawal S, Zhao Q: Antisense therapeutics. Curr Opin Chem Biol. 1998, 2: 519-528. 10.1016/S1367-5931(98)80129-4.
Article
CAS
Google Scholar
Mutwiri GK, Nichani AK, Babiuk S, Babiuk LA: Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J Control Release. 2004, 97: 1-17. 10.1016/j.jconrel.2004.02.022.
Article
CAS
Google Scholar
Brown DA, Kang SH, Gryaznov SM, DeDionisio L, Heidenreich O, Sullivan S, Xu X, Nerenberg MI: Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J Biol Chem. 1994, 269: 26801-26805.
CAS
Google Scholar
Crooke RM: In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anticancer Drug Des. 1991, 6: 609-646.
CAS
Google Scholar
Chuang TH, Lee J, Kline L, Mathison JC, Ulevitch RJ: Toll-like receptor 9 mediates CpG-DNA signaling. J Leukoc Biol. 2002, 71: 538-544.
CAS
Google Scholar
Nielsen PE, Egholm M, Berg RH, Buchardt O: Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science. 1991, 254: 1497-1500. 10.1126/science.1962210.
Article
CAS
Google Scholar
Bauer S, Kirschning CJ, Häcker H, Redecke V, Hausmann S, Akira S, Wagner H, Lipford GB: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA. 2001, 98: 9237-9242. 10.1073/pnas.161293498.
Article
CAS
Google Scholar
Zimmermann S, Heeg K, Dalpke A: Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3' sequence modifications. Vaccine. 2003, 21: 990-995. 10.1016/S0264-410X(02)00550-9.
Article
CAS
Google Scholar
Lee SW, Song MK, Baek KH, Park Y, Kim JK, Lee CH, Cheong HK, Cheong C, Sung YC: Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J Immunol. 2000, 165: 3631-3639.
Article
CAS
Google Scholar
Bartz H, Mendoza Y, Gebker M, Fischborn T, Heeg K, Dalpke A: Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytes. Vaccine. 2004, 23: 148-155. 10.1016/j.vaccine.2004.05.020.
Article
CAS
Google Scholar
Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, Wagner H: The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity. 2008, 28: 315-323. 10.1016/j.immuni.2008.01.013.
Article
CAS
Google Scholar
Yu D, Zhao Q, Kandimalla ER, Agrawal S: Accessible 5'-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity. Bioorg Med Chem Lett. 2000, 10: 2585-2588. 10.1016/S0960-894X(00)00537-0.
Article
CAS
Google Scholar
Putta MR, Zhu FG, Wang D, Bhagat L, Dai M, Kandimalla ER, Agrawal S: Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity. Bioconjug Chem. 2010, 21: 39-45. 10.1021/bc900425s.
Article
CAS
Google Scholar
Klein DCG, Latz E, Espevik T, Stokke BT: Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy. Ultramicroscopy. 2010, 110: 689-693. 10.1016/j.ultramic.2010.02.033.
Article
CAS
Google Scholar
Maeda T, Murata K, Fukushima T, Sugahara K, Tsuruda K, Anami M, Onimaru Y, Tsukasaki K, Tomonaga M, Moriuchi R, Hasegawa H, Yamada Y, Kamihira S: A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic natural killer cell lymphoma. Int J Hematol. 2005, 81: 148-154. 10.1532/IJH97.04116.
Article
Google Scholar