Butler M: Optimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems. Cytotechnology. 2006, 50 (1–3): 57-76.

Article
CAS
Google Scholar

Lim Y, Wong NS, Lee YY, Ku SC, Wong DC, Yap MG: Engineering mammalian cells in bioprocessing - current achievements and future perspectives. Biotechnol Appl Biochem. 2010, 55 (4): 175-189.

Article
CAS
Google Scholar

Blanchard TJ, Alcami A, Andrea P, Smith GL: Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine. J Gen Virol. 1998, 79 (Pt 5): 1159-1167.

Article
CAS
Google Scholar

Draper SJ, Heeney JL: Viruses as vaccine vectors for infectious diseases and cancer. Nat Rev Microbiol. 2010, 8 (1): 62-73.

Article
CAS
Google Scholar

Jordan I, Vos A, Beilfuss S, Neubert A, Breul S, Sandig V: An avian cell line designed for production of highly attenuated viruses. Vaccine. 2009, 27 (5): 748-756.

Article
CAS
Google Scholar

Lohr V, Rath A, Genzel Y, Jordan I, Sandig V, Reichl U: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine. 2009, 27 (36): 4975-4982.

Article
CAS
Google Scholar

Nadeau I, Sabatie J, Koehl M, Perrier M, Kamen A: Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis. Metab Eng. 2000, 2 (4): 277-292.

Article
CAS
Google Scholar

Nadeau I, Jacob D, Perrier M, Kamen A: 293SF metabolic flux analysis during cell growth and infection with an adenoviral vector. Biotechnol Prog. 2000, 16 (5): 872-884.

Article
CAS
Google Scholar

Niklas J, Schrader E, Sandig V, Noll T, Heinzle E: Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess Biosyst Eng. 2011, 34 (5): 533-545.

Article
CAS
Google Scholar

Priesnitz C, Niklas J, Rose T, Sandig V, Heinzle E: Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the alpha1-antitrypsin producing human AGE1.HN cell line. Metab Eng. 2012, 14 (2): 128-137.

Article
CAS
Google Scholar

Altamirano C, Illanes A, Casablancas A, Gamez X, Cairo JJ, Godia C: Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture. Biotechnol Prog. 2001, 17 (6): 1032-1041.

Article
CAS
Google Scholar

Teixeira A, Cunha AE, Clemente JJ, Moreira JL, Cruz HJ, Alves PM, Carrondo MJ, Oliveira R: Modelling and optimization of a recombinant BHK-21 cultivation process using hybrid grey-box systems. J Biotechnol. 2005, 118 (3): 290-303.

Article
CAS
Google Scholar

Sidorenko Y, Wahl A, Dauner M, Genzel Y, Reichl U: Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media. Biotechnol Prog. 2008, 24 (2): 311-320.

Article
CAS
Google Scholar

Wahl A, Sidorenko Y, Dauner M, Genzel Y, Reichl U: Metabolic flux model for an anchorage-dependent MDCK cell line: characteristic growth phases and minimum substrate consumption flux distribution. Biotechnol Bioeng. 2008, 101 (1): 135-152.

Article
CAS
Google Scholar

Bonarius HP, Houtman JH, Schmid G, de Gooijer CD, Tramper J: Metabolic-flux analysis of hybridoma cells under oxidative and reductive stress using mass balances. Cytotechnology. 2000, 32 (2): 97-107.

Article
CAS
Google Scholar

Bonarius HP, Hatzimanikatis V, Meesters KP, de Gooijer CD, Schmid G, Tramper J: Metabolic flux analysis of hybridoma cells in different culture media using mass balances. Biotechnol Bioeng. 1996, 50 (3): 299-318.

Article
CAS
Google Scholar

Bernal V, Carinhas N, Yokomizo AY, Carrondo MJ, Alves PM: Cell density effect in the baculovirus-insect cells system: a quantitative analysis of energetic metabolism. Biotechnol Bioeng. 2009, 104 (1): 162-180.

Article
CAS
Google Scholar

Carinhas N, Bernal V, Yokomizo AY, Carrondo MJ, Oliveira R, Alves PM: Baculovirus production for gene therapy: the role of cell density, multiplicity of infection and medium exchange. Appl Microbiol Biotechnol. 2009, 81 (6): 1041-1049.

Article
CAS
Google Scholar

Kovacevic Z, Brkljac O, Bajin K: Control and function of the transamination pathways of glutamine oxidation in tumour cells. Biochem J . 1991, 273 (Pt 2): 271-275.

Article
CAS
Google Scholar

Moreadith RW, Lehninger AL: The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem. 1984, 259 (10): 6215-6221.

CAS
Google Scholar

Reitzer LJ, Wice BM, Kennell D: Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem. 1979, 254 (8): 2669-2676.

CAS
Google Scholar

Glacken MW, Fleischaker RJ, Sinskey AJ: Reduction of waste product excretion via nutrient control: possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol Bioeng. 1986, 28 (9): 1376-1389.

Article
CAS
Google Scholar

Miller WM, Blanch HW, Wilke CR: A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: effect of nutrient concentration, dilution rate, and pH. Biotechnol Bioeng. 1988, 32 (8): 947-965.

Article
CAS
Google Scholar

Boghigian BA, Seth G, Kiss R, Pfeifer BA: Metabolic flux analysis and pharmaceutical production. Metab Eng. 2010, 12 (2): 81-95.

Article
CAS
Google Scholar

Quek LE, Dietmair S, Kromer JO, Nielsen LK: Metabolic flux analysis in mammalian cell culture. Metab Eng. 2010, 12 (2): 161-171.

Article
CAS
Google Scholar

Ahn WS, Antoniewicz MR: Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry. Metab Eng. 2011, 13 (5): 598-609.

Article
CAS
Google Scholar

Mahadevan R, Schilling CH: The effects of alternate optimal solutions in constraint-based genome-scale metabolic models. Metab Eng. 2003, 5 (4): 264-276.

Article
CAS
Google Scholar

Klamt S, Saez-Rodriguez J, Gilles ED: Structural and functional analysis of cellular networks with Cell NetAnalyzer. BMC Syst Biol. 2007, 1: 2

Article
Google Scholar

Xie L, Wang DI: Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor. Cytotechnology. 1994, 15 (1–3): 17-29.

Article
CAS
Google Scholar

Zupke C, Stephanopoulos G: Intracellular flux analysis in hybridomas using mass balances and in vitro (13)C nmr. Biotechnol Bioeng. 1995, 45 (4): 292-303.

Article
CAS
Google Scholar

Carnicer M, Baumann K, Toplitz I, Sanchez-Ferrando F, Mattanovich D, Ferrer P, Albiol J: Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels. Microb Cell Fact. 2009, 8: 65

Article
Google Scholar

Selvarasu S, Ho YS, Chong WP, Wong NS, Yusufi FN, Lee YY, Yap MG, Lee DY: Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng. 2012, 109 (6): 1415-1429.

Article
CAS
Google Scholar

Ferrance JP, Goel A, Ataai MM: Utilization of glucose and amino acids in insect cell cultures: quantifying the metabolic flows within the primary pathways and medium development. Biotechnol Bioeng. 1993, 42 (6): 697-707.

Article
CAS
Google Scholar

Xie L, Wang DI: Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies. Biotechnol Bioeng. 1994, 43 (11): 1175-1189.

Article
CAS
Google Scholar

Lohr V, Genzel Y, Jordan I, Katinger D, Mahr S, Sandig V, Reichl U: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. BMC Biotechnol. 2012, 12: 79

Article
CAS
Google Scholar

Niklas J, Priesnitz C, Rose T, Sandig V, Heinzle E: Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and alpha1-antitrypsin production at reduced pyruvate load. Appl Microbiol Biotechnol. 2012, 93 (4): 1637-1650.

Article
CAS
Google Scholar

Schneider M, Marison IW, von Stockar U: The importance of ammonia in mammalian cell culture. J Biotechnol. 1996, 46 (3): 161-185.

Article
CAS
Google Scholar

Yang M, Butler M: Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture. Biotechnol Prog. 2000, 16 (5): 751-759.

Article
CAS
Google Scholar

Slivac I, Blajic V, Radosevic K, Kniewald Z, Gaurina Srcek V: Influence of different ammonium, lactate and glutamine concentrations on CCO cell growth. Cytotechnology. 2010, 62 (6): 585-594.

Article
CAS
Google Scholar

Stevens L: Avian Biochemistry and Molecular Biology. 1996, Cambridge: Cambridge University Press

Book
Google Scholar

Fitzpatrick L, Jenkins HA, Butler M: Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture. Appl Biochem Biotechnol. 1993, 43 (2): 93-116.

Article
CAS
Google Scholar

Neermann J, Wagner R: Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol. 1996, 166 (1): 152-169.

Article
CAS
Google Scholar

Xie L, Wang DI: Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network. Biotechnol Bioeng. 1996, 52 (5): 591-601.

Article
CAS
Google Scholar

Zamorano F, Wouwer AV, Bastin G: A detailed metabolic flux analysis of an underdetermined network of CHO cells. J Biotechnol. 2010, 150 (4): 497-508.

Article
CAS
Google Scholar

Janke R, Genzel Y, Handel N, Wahl A, Reichl U: Metabolic adaptation of MDCK cells to different growth conditions: effects on catalytic activities of central metabolic enzymes. Biotechnology and bioengineering. 2011, 108 (11): 2691-2704.

Article
CAS
Google Scholar

Janke R, Genzel Y, Wahl A, Reichl U: Measurement of key enzyme activities in mammalian cell lines using rapid and sensitive microplate-based assays. Biotechnol Bioeng. 2010, 107 (3): 566-81.

Article
CAS
Google Scholar

Taschwer M, Hackl M, Hernandez Bort JA, Leitner C, Kumar N, Puc U, Grass J, Papst M, Kunert R, Altmann F, Borth N: Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth. J Biotechnol. 2012, 157 (2): 295-303.

Article
CAS
Google Scholar

Capiaumont J, Legrand C, Carbonell D, Dousset B, Belleville F, Nabet P: Methods for reducing the ammonia in hybridoma cell cultures. J Biotechnol. 1995, 39 (1): 49-58.

Article
CAS
Google Scholar

Hassell T, Gleave S, Butler M: Growth inhibition in animal cell culture. The effect of lactate and ammonia. Appl Biochem Biotechnol. 1991, 30 (1): 29-41.

Article
CAS
Google Scholar

Fuchs BC, Bode BP: Stressing out over survival: glutamine as an apoptotic modulator. J Surg Res. 2006, 131 (1): 26-40.

Article
CAS
Google Scholar

Niederlechner S, Klawitter J, Baird C, Kallweit AR, Christians U, Wischmeyer PE: Fibronectin-integrin signaling is required for L-glutamine’s protection against gut injury. PLoS One. 2012, 7 (11): e50185

Article
CAS
Google Scholar

Chen P, Harcum SW: Effects of amino acid additions on ammonium stressed CHO cells. J Biotechnol. 2005, 117 (3): 277-286.

Article
CAS
Google Scholar

Genzel Y, Ritter JB, König S, Alt R, Reichl U: Substitution of glutamine by pyruvate to reduce ammonia formation and growth inhibition of mammalian cells. Biotechnol Prog. 2005, 21 (1): 58-69.

Article
CAS
Google Scholar

Buentemeyer H: Methods for off-line analysis of nutrients and products in mammalian cell culture. Methods in Biotechnology. Volume 24. Edited by: Poertner R. 2007, New York: Humana Press Inc, 253-268. 2

Google Scholar

Stephanopoulos GN, Aristidou AA, Nielsen J: Metabolic Engineering - Principles and Methodologies. 1998, Orlando: Academic Press

Google Scholar

Ozturk SS, Palsson BO: Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration. Biotechnol Prog. 1990, 6 (2): 121-128.

Article
CAS
Google Scholar

van der Heijden RT, Heijnen JJ, Hellinga C, Romein B, Luyben KC: Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol Bioeng. 1994, 43 (1): 3-10.

Article
CAS
Google Scholar

Klamt S, Schuster S, Gilles ED: Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria. Biotechnol Bioeng. 2002, 77 (7): 734-751.

Article
CAS
Google Scholar

Orth JD, Thiele I, Palsson BO: What is flux balance analysis?. Nat Biotechnol. 2010, 28 (3): 245-248.

Article
CAS
Google Scholar

Llaneras F, Pico J: An interval approach for dealing with flux distributions and elementary modes activity patterns. J Theor Biol. 2007, 246 (2): 290-308.

Article
CAS
Google Scholar

Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW: Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnol Bioeng. 1994, 44 (5): 563-585.

Article
CAS
Google Scholar