Schindler C: Cytokines and JAK-STAT signaling. Exp Cell Res. 1999, 253: 7-14. 10.1006/excr.1999.4670.
Article
CAS
Google Scholar
Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD: How cells respond to interferons. Annu Rev Biochem. 1998, 67: 227-264. 10.1146/annurev.biochem.67.1.227.
Article
CAS
Google Scholar
Darnell JE: STATs and gene regulation. Science. 1997, 277: 1630-1635. 10.1126/science.277.5332.1630.
Article
CAS
Google Scholar
Ihle JN: The Stat family in cytokine signaling. Curr Opin Cell Biol. 2001, 13: 211-217. 10.1016/S0955-0674(00)00199-X.
Article
CAS
Google Scholar
O'Shea JJ, Gadina M, Schreiber RD: Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002, 109 Suppl: S121-31. 10.1016/S0092-8674(02)00701-8.
Article
Google Scholar
Durbin JE, Hackenmiller R, Simon MC, Levy DE: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996, 84: 443-450. 10.1016/S0092-8674(00)81289-1.
Article
CAS
Google Scholar
Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD: Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996, 84: 431-442. 10.1016/S0092-8674(00)81288-X.
Article
CAS
Google Scholar
Mui AL: The role of STATs in proliferation, differentiation, and apoptosis. Cell Mol Life Sci. 1999, 55: 1547-1558. 10.1007/s000180050394.
Article
CAS
Google Scholar
Chatterjee-Kishore M, Wright KL, Ting JP, Stark GR: How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. Embo J. 2000, 19: 4111-4122. 10.1093/emboj/19.15.4111.
Article
CAS
Google Scholar
Stockinger S, Materna T, Stoiber D, Bayr L, Steinborn R, Kolbe T, Unger H, Chakraborty T, Levy DE, Muller M, Decker T: Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol. 2002, 169: 6522-6529.
Article
CAS
Google Scholar
Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Muller M: Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity. 2000, 13: 549-560. 10.1016/S1074-7613(00)00054-6.
Article
CAS
Google Scholar
Bockamp E, Maringer M, Spangenberg C, Fees S, Fraser S, Eshkind L, Oesch F, Zabel B: Of mice and models: improved animal models for biomedical research. Physiol Genomics. 2002, 11: 115-132.
Article
CAS
Google Scholar
Pollock R, Clackson T: Dimerizer-regulated gene expression. Curr Opin Biotechnol. 2002, 13: 459-467. 10.1016/S0958-1669(02)00373-7.
Article
CAS
Google Scholar
Pollock R, Giel M, Linher K, Clackson T: Regulation of endogenous gene expression with a small-molecule dimerizer. Nat Biotechnol. 2002, 20: 729-733. 10.1038/nbt0702-729.
Article
CAS
Google Scholar
Rivera VM, Clackson T, Natesan S, Pollock R, Amara JF, Keenan T, Magari SR, Phillips T, Courage NL, Cerasoli F, Holt DA, Gilman M: A humanized system for pharmacologic control of gene expression. Nat Med. 1996, 2: 1028-1032. 10.1038/nm0996-1028.
Article
CAS
Google Scholar
Rivera VM, Ye X, Courage NL, Sachar J, Cerasoli F, Wilson JM, Gilman M: Long-term regulated expression of growth hormone in mice after intramuscular gene transfer. Proc Natl Acad Sci U S A. 1999, 96: 8657-8662. 10.1073/pnas.96.15.8657.
Article
CAS
Google Scholar
Magari SR, Rivera VM, Iuliucci JD, Gilman M, Cerasoli F: Pharmacologic control of a humanized gene therapy system implanted into nude mice. J Clin Invest. 1997, 100: 2865-2872.
Article
CAS
Google Scholar
Brooks AR, Harkins RN, Wang P, Qian HS, Liu P, Rubanyi GM: Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med. 2004, 6: 395-404. 10.1002/jgm.516.
Article
CAS
Google Scholar
Choi KH, Basma H, Singh J, Cheng PW: Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. Glycoconj J. 2005, 22: 63-69. 10.1007/s10719-005-0326-1.
Article
CAS
Google Scholar
Perez-Losada J, Pintado B, Gutierrez-Adan A, Flores T, Banares-Gonzalez B, del Campo JC, Martin-Martin JF, Battaner E, Sanchez-Garcia I: The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. Oncogene. 2000, 19: 2413-2422. 10.1038/sj.onc.1203572.
Article
CAS
Google Scholar
Ikeguchi Y, Wang X, McCloskey DE, Coleman CS, Nelson P, Hu G, Shantz LM, Pegg AE: Characterization of transgenic mice with widespread overexpression of spermine synthase. Biochem J. 2004, 381: 701-707. 10.1042/BJ20040419.
Article
CAS
Google Scholar
Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y: 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 1997, 407: 313-319. 10.1016/S0014-5793(97)00313-X.
Article
CAS
Google Scholar
Mizushima S, Nagata S: pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 1990, 18: 5322-10.1093/nar/18.17.5322.
Article
CAS
Google Scholar
Niwa H, Yamamura K, Miyazaki J: Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 1991, 108: 193-199. 10.1016/0378-1119(91)90434-D.
Article
CAS
Google Scholar
Ting DT, Kyba M, Daley GQ: Inducible transgene expression in mouse stem cells. Methods Mol Med. 2005, 105: 23-46.
CAS
Google Scholar
Kearns M, Preis J, McDonald M, Morris C, Whitelaw E: Complex patterns of inheritance of an imprinted murine transgene suggest incomplete germline erasure. Nucleic Acids Res. 2000, 28: 3301-3309. 10.1093/nar/28.17.3301.
Article
CAS
Google Scholar
Sutherland HG, Kearns M, Morgan HD, Headley AP, Morris C, Martin DI, Whitelaw E: Reactivation of heritably silenced gene expression in mice. Mamm Genome. 2000, 11: 347-355. 10.1007/s003350010066.
Article
CAS
Google Scholar
Recillas-Targa F, Valadez-Graham V, Farrell CM: Prospects and implications of using chromatin insulators in gene therapy and transgenesis. Bioessays. 2004, 26: 796-807. 10.1002/bies.20059.
Article
CAS
Google Scholar
Beard C, Hochedlinger K, Plath K, Wutz A, Jaenisch R: Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis. 2006, 44: 23-28. 10.1002/gene.20180.
Article
CAS
Google Scholar
Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittmann M, Greenberg NM, Spencer DM: Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Res. 2003, 63: 8256-8263.
CAS
Google Scholar
Chong H, Ruchatz A, Clackson T, Rivera VM, Vile RG: A system for small-molecule control of conditionally replication-competent adenoviral vectors. Mol Ther. 2002, 5: 195-203. 10.1006/mthe.2002.0531.
Article
CAS
Google Scholar
Crittenden M, Gough M, Chester J, Kottke T, Thompson J, Ruchatz A, Clackson T, Cosset FL, Chong H, Diaz RM, Harrington K, Alvarez Vallina L, Vile R: Pharmacologically regulated production of targeted retrovirus from T cells for systemic antitumor gene therapy. Cancer Res. 2003, 63: 3173-3180.
CAS
Google Scholar
Weber W, Fussenegger M: Pharmacologic transgene control systems for gene therapy. J Gene Med. 2006, 8: 535-556. 10.1002/jgm.903.
Article
CAS
Google Scholar
Kovarik P, Mangold M, Ramsauer K, Heidari H, Steinborn R, Zotter A, Levy DE, Muller M, Decker T: Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. Embo J. 2001, 20: 91-100. 10.1093/emboj/20.1.91.
Article
CAS
Google Scholar
Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE: Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A. 1992, 89: 7836-7839. 10.1073/pnas.89.16.7836.
Article
CAS
Google Scholar
Knappik A, Pluckthun A: An improved affinity tag based on the FLAG peptide for the detection and purification of recombinant antibody fragments. Biotechniques. 1994, 17: 754-761.
CAS
Google Scholar
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998, 93: 397-409. 10.1016/S0092-8674(00)81168-X.
Article
CAS
Google Scholar
Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Muller M: Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol. 2005, 175: 4000-4008.
Article
CAS
Google Scholar
Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, Pellegrini S, Wilks AF, Ihle JN, Stark GR, Kerr IM: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993, 366: 129-135. 10.1038/366129a0.
Article
CAS
Google Scholar
Lillemeier BF, Koster M, Kerr IM: STAT1 from the cell membrane to the DNA. Embo J. 2001, 20: 2508-2517. 10.1093/emboj/20.10.2508.
Article
CAS
Google Scholar
Karaghiosoff M, Steinborn R, Kovarik P, Kriegshauser G, Baccarini M, Donabauer B, Reichart U, Kolbe T, Bogdan C, Leanderson T, Levy D, Decker T, Muller M: Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol. 2003, 4: 471-477. 10.1038/ni910.
Article
CAS
Google Scholar
Pattyn F, Speleman F, De Paepe A, Vandesompele J: RTPrimerDB: the real-time PCR primer and probe database. Nucleic Acids Res. 2003, 31: 122-123. 10.1093/nar/gkg011.
Article
CAS
Google Scholar
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