Poland GA, Jacobson RM, Targonski PV: Avian and pandemic influenza: An overview. Vaccine. 2007, 25: 3057-3061. 10.1016/j.vaccine.2007.01.050.
Article
Google Scholar
Kendal AP, Maassab HF, Alexandrova GI, Ghendon YZ: Development of cold-adapted recombinant live, attenuated influenza A vaccines in the U.S.A. and U.S.S.R. Antivir Res. 1982, 1 (6): 339-365. 10.1016/0166-3542(82)90034-1.
Article
Google Scholar
ADIS: Influenza Virus Vaccine Live Intranasal - MedImmune Vaccines: CAIV-T, Influenza Vaccine Live Intranasal. Drugs R D. 2003, 4 (5): 312-319. 10.2165/00126839-200304050-00007.
Article
Google Scholar
Maassab HF, Bryant ML: The development of live attenuated cold-adapted influenza virus vaccine for humans. Rev Med Virol. 1999, 9: 237-244. 10.1002/(SICI)1099-1654(199910/12)9:4<237::AID-RMV252>3.0.CO;2-G.
Article
Google Scholar
Belshe R, Lee M-S, Walker RE, Stoddard J, Mendelman PM: Safety, immunogenicity and efficacy of intranasal, live attenuated influenza vaccine. Expert Rev Vaccines. 2004, 3 (6): 643-654. 10.1586/14760584.3.6.643.
Article
Google Scholar
Richt JA, García-Sastre A: Attenuated influenza virus vaccines with modified NS1 proteins. Curr Top Microbiol Immunol. 2009, 333: 177-195. 10.1007/978-3-540-92165-3_9.
Google Scholar
Treanor JJ, Kotloff K, Betts RF, Belshe R, Newman F, Iacuzio D, Wittes J, Bryant M: Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses. Vaccine. 1999, 18 (9-10): 899-906. 10.1016/S0264-410X(99)00334-5.
Article
Google Scholar
García-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, Palese P, Muster T: Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems. Virology. 1998, 252 (2): 324-330. 10.1006/viro.1998.9508.
Article
Google Scholar
Hai R, Martínez-Sobrido L, Fraser KA, Ayllon J, García-Sastre A, Palese P: Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach. J Virol. 2008, 82 (21): 10580-10590. 10.1128/JVI.01213-08.
Article
Google Scholar
Steel J, Lowen AC, Pena L, Angel M, Solórzano A, Albrecht R, Perez DR, García-Sastre A, Palese P: Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza. J Virol. 2009, 83 (4): 1742-1753. 10.1128/JVI.01920-08.
Article
Google Scholar
Talon J, Salvatore M, O'Neill RE, Nakaya Y, Zheng H, Muster T, García-Sastre A, Palese P: Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach. Proc Natl Acad Sci USA. 2000, 97 (8): 4309-4314. 10.1073/pnas.070525997.
Article
Google Scholar
Wacheck V, Egorov A, Groiss F, Pfeiffer A, Fuereder T, Hoeflmayer D, Kundi M, Popow-Kraupp T, Redlberger-Fritz M, Mueller CA, et al: A Novel Type of Influenza Vaccine: Safety and Immunogenicity of Replication-Deficient Influenza Virus Created by Deletion of the Interferon Antagonist NS1. J Infect Dis. 2010, 201: 354-362. 10.1086/649428.
Article
Google Scholar
Kochs G, García-Sastre A, Martínez-Sobrido L: Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol. 2007, 81 (13): 7011-7021. 10.1128/JVI.02581-06.
Article
Google Scholar
Diaz MO, Ziemin S, Le Beau MM, Pitha P, Smith SD, Chilcote RR, Rowley JD: Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines. Proc Natl Acad Sci USA. 1988, 85 (14): 5259-5263. 10.1073/pnas.85.14.5259.
Article
Google Scholar
Mosca JD, Pitha PM: Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis. Mol Cell Biol. 1986, 6 (6): 2279-2283.
Article
Google Scholar
Egorov A, Brandt S, Sereinig S, Romanova J, Ferko B, Katinger D, Grassauer A, Alexandrova G, Katinger H, Muster T: Transfectant Influenza A Viruses with Long Deletions in the NS1 Protein Grow Efficiently in Vero Cells. J Virol. 1998, 72 (8): 6437-6441.
Google Scholar
Wressnigg N, Shurygina AP, Wolff T, Redlberger-Fritz M, Popow-Kraupp T, Muster T, Egorov A, Kittel C: Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice. J Gen Virol. 2009, 90: 366-374. 10.1099/vir.0.006122-0.
Article
Google Scholar
Efferson CL, Schickli J, Ko BK, Kawano K, Mouzi S, Palese P, García-Sastre A, Ioannides CG: Activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene. J Virol. 2003, 77 (13): 7411-7424. 10.1128/JVI.77.13.7411-7424.2003.
Article
Google Scholar
Efferson CL, Tsuda N, Kawano K, Nistal-Villán E, Sellappan S, Yu D, Murray JL, García-Sastre A, Ioannides CG: Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells To Recognize Noninfected Tumor Cells. J Virol. 2006, 80 (1): 383-394. 10.1128/JVI.80.1.383-394.2006.
Article
Google Scholar
He Q, Martinez-Sobrido L, Eko FO, Palese P, Garcia-Sastre A, Lyn D, Okenu D, Bandea C, Ananaba GA, Black CM, et al: Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines. Immunology. 2007, 122 (1): 28-37. 10.1111/j.1365-2567.2007.02608.x.
Article
Google Scholar
Genzel Y, Reichl U: Continuous cell lines as a production system for influenza vaccines. Expert Rev Vaccines. 2009, 8 (12): 1681-1692. 10.1586/erv.09.128.
Article
Google Scholar
Hu AY-C, Weng T-C, Tseng Y-F, Chen Y-S, Wu C-H, Hsiao S, Chou A-H, Chao H-J, Gu A, Wu S-C, et al: Microcarrier-based MDCK cell culture system for the production of influenza H5N1 vaccines. Vaccine. 2008, 26 (45): 5736-5740. 10.1016/j.vaccine.2008.08.015.
Article
Google Scholar
Pau MG, Ophorst C, Koldijk MH, Schouten G, Mehtali M, Uytdehaag F: The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine. 2001, 19: 2716-2721. 10.1016/S0264-410X(00)00508-9.
Article
Google Scholar
Ambrozaitis A, Groth N, Bugarini R, Sparacio V, Podda A, Lattanzi M: A novel mammalian cell-culture technique for consistent production of a well-tolerated and immunogenic trivalent subunit influenza vaccine. Vaccine. 2009, 27 (43): 6022-6029. 10.1016/j.vaccine.2009.07.083.
Article
Google Scholar
Doroshenko A, Halperin SA: Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines). Expert Rev Vaccines. 2009, 8 (6): 679-688. 10.1586/erv.09.31.
Article
Google Scholar
Genzel Y, Fischer M, Reichl U: Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine. 2006, 24 (16): 3261-3272. 10.1016/j.vaccine.2006.01.019.
Article
Google Scholar
Genzel Y, Olmer RM, Schäfer B, Reichl U: Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine. 2006, 24 (35-36): 6074-6087. 10.1016/j.vaccine.2006.05.023.
Article
Google Scholar
Ghendon YZ, Markushin SG, Akopova II, Koptiaeva IB, Nechaeva EA, Mazurkova LA, Radaeva IF, Kolokoltseva TD: Development of cell culture (MDCK) live cold-adapted (CA) attenuated influenza vaccine. Vaccine. 2005, 23 (38): 4678-4684. 10.1016/j.vaccine.2005.04.039.
Article
Google Scholar
Liu J, Mani S, Schwartz R, Richman L, Tabor DE: Cloning and assessment of tumorigenicity and oncogenicity of a Madin-Darby canine kidney (MDCK) cell line for influenza vaccine production. Vaccine. 2010, 28 (5): 1285-1293. 10.1016/j.vaccine.2009.11.023.
Article
Google Scholar
Liu J, Shi X, Schwartz R, Kemble G: Use of MDCK cells for production of live attenuated influenza vaccine. Vaccine. 2009, 27 (46): 6460-6463. 10.1016/j.vaccine.2009.06.024.
Article
Google Scholar
Hu W-S, Giard DJ, Wang DIC: Serial Propagation of Mammalian Cells on Microcarriers. Biotechnol Bioeng. 1985, 27 (10): 1466-1476. 10.1002/bit.260271011.
Article
Google Scholar
Kistner O, Barrett PN, Mundt W, Reiter M, Schober-Bendixen S, Dorner F: Development of a mammalian cell (Vero) derived candidate influenza virus vaccine. Vaccine. 1998, 16 (9-10): 960-968. 10.1016/S0264-410X(97)00301-0.
Article
Google Scholar
Ng Y-C, Berry JM, Butler M: Optimization of physical parameters for cell attachment and growth on macroporous microcarriers. Biotechnol Bioeng. 1996, 50 (6): 627-635. 10.1002/(SICI)1097-0290(19960620)50:6<627::AID-BIT3>3.0.CO;2-M.
Article
Google Scholar
Yokomizo AY, Antoniazzi MM, Galdino PL, A N, Jorge SAC, Pereira CA: Rabies virus production in high vero cell density cultures on macroporous microcarriers. Biotechnol Bioeng. 2004, 85 (5): 506-515. 10.1002/bit.10917.
Article
Google Scholar
Genzel Y, Dietzsch C, Rapp E, Schwarzer J, Reichl U: MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Appl Microbiol Biotechnol. 2010, 88 (2): 461-475. 10.1007/s00253-010-2742-9.
Article
Google Scholar
Cinatl JJ, Cinatl J, Rabenau H, Rapp J, Kornhuber B, Doerr H: Protein-free culture of Vero cells: A substrate for replication of pathogenic viruses. Cell Biol Int. 1993, 17 (9): 885-895. 10.1006/cbir.1993.1152.
Article
Google Scholar
Merten O-W, Kierulff JV, Castignolles N, Perrin P: Evaluation of the new serum free medium (MDSS2) for the production of different biologicals: use of various cell lines. Cytotechnology. 1994, 14 (1): 47-59. 10.1007/BF00772195.
Article
Google Scholar
Yuk IH, Lin GB, Ju H, Sifi I, Lam Y, Cortez A, Liebertz D, Berry JM, Schwartz RM: A serum-free Vero production platform for a chimeric virus vaccine candidate. Cytotechnology. 2006, 51: 183-192. 10.1007/s10616-006-9030-7.
Article
Google Scholar
Rourou S, van der Ark A, van der Velden T, Kallel H: A microcarrier cell culture process for propagating rabies virus in Vero cells grown in a stirred bioreactor under fully animal component free conditions. Vaccine. 2007, 25 (19): 3879-3889. 10.1016/j.vaccine.2007.01.086.
Article
Google Scholar
Tiwari M, Parida M, Santhosh SR, Khan M, Dash PK, Rao PVL: Assessment of immunogenic potential of Vero adapted formalin inactivated vaccine derived from novel ECSA genotype of Chikungunya virus. Vaccine. 2009, 27 (18): 2513-2522. 10.1016/j.vaccine.2009.02.062.
Article
Google Scholar
Souza MCO, Freire MS, Schulze EA, Gaspar LP, Castilho LR: Production of yellow fever virus in microcarrier-based vero cell cultures. Vaccine. 2009, 27 (46): 6420-6423. 10.1016/j.vaccine.2009.06.023.
Article
Google Scholar
Silva AC, Delgado I, Sousa MFQ, Carrondo MJT, Alves PM: Scalable culture systems using different cell lines for the production of Peste des Petits ruminants vaccine. Vaccine. 2008, 26: 3305-3311. 10.1016/j.vaccine.2008.03.077.
Article
Google Scholar
Liu C-C, Lian W-C, Butler M, Wu S-C: High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture. Vaccine. 2007, 25 (1): 19-24. 10.1016/j.vaccine.2006.06.083.
Article
Google Scholar
Butler M, Burgener A, Patrick M, Berry M, Moffatt D, Huzel N, Barnabé N, Coombs K: Application of a Serum-Free Medium for the Growth of Vero Cells and the Production of Reovirus. Biotechnol Prog. 2000, 16 (5): 854-858. 10.1021/bp000110+.
Article
Google Scholar
Rourou S, van der Ark A, Majoul S, Trabelsi K, van der Velden T, Kallel H: A novel animal-component-free medium for rabies virus production in Vero cells grown on Cytodex 1 microcarriers in a stirred bioreactor. Appl Microbiol Biotechnol. 2009, 85 (1): 53-63. 10.1007/s00253-009-2064-y.
Article
Google Scholar
Petiot E, Fournier F, Gény C, Pinton H, Marc A: Rapid Screening of Serum-Free Media for the Growth of Adherent Vero Cells by Using a Small-Scale and Non-invasive Tool. Appl Biochem Biotechnol. 2010, 160 (6): 1600-1615. 10.1007/s12010-009-8674-0.
Article
Google Scholar
Frazzati-Gallina NM, Paoli RL, Mourão-Fuches RM, Jorge SAC, Pereira CA: Higher production of rabies virus in serum-free medium cell cultures on microcarriers. J Biotechnol. 2001, 92: 67-72. 10.1016/S0168-1656(01)00362-5.
Article
Google Scholar
Quesney S, Marvel J, Gerdil C, Meignier B: Characterization of Vero cell growth and death in bioreactor with serum-containing and serum-free media. Cytotechnology. 2001, 35: 115-125. 10.1023/A:1017589526145.
Article
Google Scholar
Souza MCdO, Freire MdS, Castilho LdR: Influence of Culture Conditions on Vero Cell Propagation on Non-Porous Microcarriers. Braz Arch Biol Technol. 2005, 48: 71-77.
Google Scholar
Quesney Sb, Marc A, Gerdil C, Gimenez C, Marvel J, Richard Y, Meignier B: Kinetics and metabolic specificities of Vero cells in bioreactor cultures with serum-free medium. Cytotechnology. 2003, 42: 1-11. 10.1023/A:1026185615650.
Article
Google Scholar
Wood HA, Johnston LB, Burand JP: Inhibition of Autographa californica Nuclear Polyhedrosis Virus Replication in High-Density Trichoplusia ni Cell Culture. Virology. 1982, 119: 245-254. 10.1016/0042-6822(82)90085-X.
Article
Google Scholar
Kamen A, Henry O: Development and optimization of an adenovirus production process. J Gene Med. 2004, 6: S184-S192. 10.1002/jgm.503.
Article
Google Scholar
Yuk IHY, Olsen MM, Geyer S, Forestell SP: Perfusion cultures of human tumor cells: a scalable production platform for oncolytic adenoviral vectors. Biotechnol Bioeng. 2004, 86 (6): 637-642. 10.1002/bit.20158.
Article
Google Scholar
Bock A, Schulze-Horsel J, Rapp E, Genzel Y, Reichl U: High-Density Microcarrier Cell Cultures for Influenza Virus Production. Biotechnol Prog. 2011, 27 (1): 241-250. 10.1002/btpr.539.
Article
Google Scholar
Ghani K, Garnier A, Coelho H, Transfiguracion J, Trudel P, Kamen A: Retroviral vector production using suspension-adapted 293GPG cells in a 3L acoustic filter-based perfusion bioreactor. Biotechnol Bioeng. 2006, 95 (4): 653-660. 10.1002/bit.20947.
Article
Google Scholar
Merten O-W: State-of-the-art of the production of retroviral vectors. J Gene Med. 2004, 6: S105-S124. 10.1002/jgm.499.
Article
Google Scholar
Beer C, Meyer A, Müller K, Wirth M: The temperature stability of mouse retroviruses depends on the cholesterol levels of viral lipid shell and cellular plasma membrane. Virology. 2003, 308 (1): 137-146. 10.1016/S0042-6822(02)00087-9.
Article
Google Scholar
Le Rub A, Jacob D, Transfiguracion J, Ansorge S, Henry O, Kamen AA: Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing. Vaccine. 2010, 28 (21): 3661-3671. 10.1016/j.vaccine.2010.03.029.
Article
Google Scholar
Barber GN: Host defense, viruses and apoptosis. Cell Death Differ. 2001, 8 (2): 113-126. 10.1038/sj.cdd.4400823.
Article
Google Scholar
Bergmann M, Garcia-Sastre A, Carnero E, Pehamberger H, Wolff K, Palese P, Muster T: Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication. J Virol. 2000, 74 (13): 6203-6206. 10.1128/JVI.74.13.6203-6206.2000.
Article
Google Scholar
Hayman A, Comely S, Lackenby A, Hartgroves LCS, Goodbourn S, McCauley JW, Barclay WS: NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response. J Virol. 2007, 81 (5): 2318-2327. 10.1128/JVI.01856-06.
Article
Google Scholar
Ehrhardt C, Ludwig S: A new player in a deadly game: influenza viruses and the PI3K/Akt signaling pathway. Cell Microbiol. 2009, 11 (6): 863-871. 10.1111/j.1462-5822.2009.01309.x.
Article
Google Scholar
Zhirnov OP, Konakova TE, Wolff T, Klenk HD: NS1 Protein of Influenza A Virus Down-Regulates Apoptosis. J Virol. 2002, 76 (4): 1617-1625. 10.1128/JVI.76.4.1617-1625.2002.
Article
Google Scholar
Ehrhardt C, Wolff T, Ludwig S: Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses. J Virol. 2007, 81 (21): 12097-12100. 10.1128/JVI.01216-07.
Article
Google Scholar
Seitz C, Frensing T, Höper D, Kochs G, Reichl U: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. J Gen Virol. 2010, 91 (7): 1754-1763. 10.1099/vir.0.020370-0.
Article
Google Scholar
Genzel Y, Behrendt I, Konig S, Sann H, Reichl U: Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine. 2004, 22: 2202-2208. 10.1016/j.vaccine.2003.11.041.
Article
Google Scholar
Matlin KS: Ammonium Chloride Slows Transport of the Influenza Virus Hemagglutinin but Does Not Cause Mis-sorting in a Polarized Epthelial Cell Line. J Biol Chem. 1986, 261 (32): 15172-15178.
Google Scholar
Morris SJ, Price GE, Barnett JM, Hiscox SA, Smith H, Sweet C: Role of neuraminidase in influenza virus-induced apoptosis. J Gen Virol. 1999, 80: 137-146.
Article
Google Scholar
Whittaker G, Bui M, Helenius A: The role of nuclear import and export in influenza virus infection. Trends Cell Biol. 1996, 6: 67-71. 10.1016/0962-8924(96)81017-8.
Article
Google Scholar
Cox N: WHO manual on animal influenza diagnosis and surveillance. WHO Animal Influenza Manual. Edited by: Webster RG, Krauss S. 2002, Geneva: World Health Organization, 1-97.
Google Scholar
Reed LJ, Muench H: A simple method of estimating fifty per cent endpoints. The American Journal of Hygiene. 1938, 27 (3): 493-497.
Google Scholar
Karrona RA, Talaat K, Luke C, Callahan K, Thumar B, DiLorenzo S, McAuliffe J, Schappell E, Suguitan A, Mills K, et al: Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults. Vaccine. 2009, 27: 4953-4960. 10.1016/j.vaccine.2009.05.099.
Article
Google Scholar
Talaat KR, Karrona RA, Callahan KA, Luke CJ, DiLorenzo SC, Chen GL, Lamirande EW, Jin H, Coelingh KL, Murphy BR, et al: A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults. Vaccine. 2009, 27: 3744-3753. 10.1016/j.vaccine.2009.03.082.
Article
Google Scholar