Ma JK, Lehner T, Stabila P, Fux CI, Hiatt A: Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur J Immunol. 1994, 24 (1): 131-138.
Article
Google Scholar
Sharp JM, Doran PM: Characterization of monoclonal antibody fragments produced by plant cells. Biotechnol Bioeng. 2001, 73 (5): 338-346.
Article
Google Scholar
Villani ME, Morgun B, Brunetti P, Marusic C, Lombardi R, Pisoni I, Bacci C, Desiderio A, Benvenuto E, Donini M: Plant pharming of a full-sized, tumour-targeting antibody using different expression strategies. Plant Biotechnology Journal. 2009, 7 (1): 59-72.
Article
Google Scholar
Outchkourov NS, Rogelj B, Strukelj B, Jongsma MA: Expression of Sea Anemone Equistatin in Potato. Effects of Plant Proteases on Heterologous Protein Production. Plant Physiol. 2003, 133 (1): 379-390.
Article
Google Scholar
De Neve M, De Loose M, Jacobs A, Van Houdt H, Kaluza B, Weidle U, Van Montagu M, Depicker A: Assembly of an antibody and its derived antibody fragment in Nicotiana and Arabidopsis. Transgenic Res. 1993, 2 (4): 227-237.
Article
Google Scholar
Engelen FA, Schouten A, Molthoff JW, Roosien J, Salinas J, Dirkse WG, Schots A, Bakker J, Gommers FJ, Jongsma MA, et al: Coordinate expression of antibody subunit genes yields high levels of functional antibodies in roots of transgenic tobacco. Plant Molecular Biology. 1994, 26 (6): 1701-1710.
Article
Google Scholar
Stevens LH, Stoopen GM, Elbers IJW, Molthoff JW, Bakker HAC, Lommen A, Bosch D, Jordi W: Effect of Climate Conditions and Plant Developmental Stage on the Stability of Antibodies Expressed in Transgenic Tobacco. Plant Physiol. 2000, 124 (1): 173-182.
Article
Google Scholar
Faye L, Boulaflous A, Benchabane M, Gomord V, Michaud D: Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming. Vaccine. 2005, 23 (15): 1770-1778.
Article
Google Scholar
Schaller A: A cut above the rest: the regulatory function of plant proteases. Planta. 2004, 220 (2): 183-197.
Article
Google Scholar
van der Hoorn RAL: Plant Proteases: From Phenotypes to Molecular Mechanisms. Annual Review of Plant Biology. 2008, 59 (1): 191-223.
Article
Google Scholar
Beyene G, Foyer CH, Kunert KJ: Two new cysteine proteinases with specific expression patterns in mature and senescent tobacco (Nicotiana tabacum L.) leaves. Journal of Experimental Botany. 2006, 57 (6): 1431-1443.
Article
Google Scholar
De Wilde C, De Rycke R, Beeckman T, De Neve M, Van Montagu M, Engler G, Depicker A: Accumulation pattern of IgG antibodies and Fab fragments in transgenic Arabidopsis thaliana plants. Plant Cell Physiol. 1998, 39 (6): 639-646.
Article
Google Scholar
Hein MB, Tang Y, McLeod DA, Janda KD, Hiatt A: Evaluation of immunoglobulins from plant cells. Biotechnol Prog. 1991, 7 (5): 455-461.
Article
Google Scholar
Benchabane M, Goulet C, Rivard D, Faye Lc, Gomord Vr, Michaud D: Preventing unintended proteolysis in plant protein biofactories. Plant biotechnology journal. 2008, 6 (7): 633-648.
Article
Google Scholar
Rivard D, Anguenot R, Brunelle F, Le VQ, Vezina LP, Trepanier S, Michaud D: An in-built proteinase inhibitor system for the protection of recombinant proteins recovered from transgenic plants. Plant Biotechnology Journal. 2006, 4 (3): 359-368.
Article
Google Scholar
Benchabane M, Saint-Jore-Dupas C, Bardor M, Faye L, Michaud D, Gomord V: Targeting and post-translational processing of human alpha1-antichymotrypsin in BY-2 tobacco cultured cells. Plant Biotechnol J. 2009, 7 (2): 146-160.
Article
Google Scholar
Michaud D: Gel electrophoresis of proteolytic enzymes. Analytica Chimica Acta. 1998, 372 (1-2): 173-185.
Article
Google Scholar
Daniell H, Chebolu S, Kumar S, Singleton M, Falconer R: Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine. 2005, 23 (15): 1779-1783.
Article
Google Scholar
Vitale A, Pedrazzini E: Recombinant Pharmaceuticals from Plants: The Plant Endomembrane System as Bioreactor. Molecular Interventions. 2005, 5 (4): 216-225.
Article
Google Scholar
Yoshida K, Matsui T, Shinmyo A: The plant vesicular transport engineering for production of useful recombinant proteins. Journal of Molecular Catalysis B: Enzymatic. 2004, 28 (4-6): 167-171.
Article
Google Scholar
Potenza C, Aleman L, Sengupta-Gopalan C: Targeting transgene expression in research, agricultural, and environmental applications: Promoters used in plant transformation. In Vitro Cellular & Developmental Biology-Plant. 2004, 40 (1): 1-22.
Article
Google Scholar
Stoger E, Ma JKC, Fischer R, Christou P: Sowing the seeds of success: pharmaceutical proteins from plants. Current Opinion in Biotechnology. 2005, 16 (2): 167-173.
Article
Google Scholar
Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I: Cosecretion of Protease Inhibitor Stabilizes Antibodies Produced by Plant Roots. Plant Physiol. 2006, 141 (4): 1185-1193.
Article
Google Scholar
Floss DM, Sack M, Arcalis E, Stadlmann J, Quendler H, Rademacher T, Stoger E, Scheller J, Fischer R, Conrad U: Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody. Plant Biotechnol J. 2009, 7 (9): 899-913.
Article
Google Scholar
Frigerio L, Vine ND, Pedrazzini E, Hein MB, Wang F, Ma JK-C, Vitale A: Assembly, Secretion, and Vacuolar Delivery of a Hybrid Immunoglobulin in Plants. Plant Physiol. 2000, 123 (4): 1483-1494.
Article
Google Scholar
Di Cola A, Frigerio L, Lord JM, Roberts LM, Ceriotti A: Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features. Plant Physiol. 2005, 137 (1): 287-296.
Article
Google Scholar
Peterson E, Owens SM, Henry RL: Monoclonal antibody form and function: manufacturing the right antibodies for treating drug abuse. AAPS J. 2006, 8 (2): E383-390.
Google Scholar
Irons SL, Nuttall J, Floß DM, Frigerio L, Kotzer AM, Hawes C: Fluorescent protein fusions to a human immunodeficiency virus monoclonal antibody reveal its intracellular transport through the plant endomembrane system. Plant Biotechnology Journal. 2008, 6 (7): 649-662.
Article
Google Scholar
Hassan S, Van Dolleweerd CJ, Ioakeimidis F, Keshavarz-Moore E, Ma JK-C: Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants. Plant Biotechnology Journal. 2008, 6 (7): 733-748.
Article
Google Scholar
Doran PM: Loss of secreted antibody from transgenic plant tissue cultures due to surface adsorption. Journal of Biotechnology. 2006, 122 (1): 39-54.
Article
Google Scholar
Peterson E, Owens SM, Henry RL: Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuse. Drug Addiction. Edited by: Rapaka RS, Sadée W. 2008, Springer New York, 87-100.
Chapter
Google Scholar
McGarry T, Hough R, Rogers S, Rechsteiner M: Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells. The Journal of Cell Biology. 1983, 96 (2): 338-346.
Article
Google Scholar
Parham P: On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice. The Journal of Immunology. 1983, 131 (6): 2895-2902.
Google Scholar
Kim J-K, Tsen M-F, Ghetie V, Sally Ward E: Evidence that the hinge region plays a role in maintaining serum levels of the murine IgG1 molecule. Molecular Immunology. 1995, 32 (7): 467-475.
Article
Google Scholar
Anelli T, Sitia R: Protein quality control in the early secretory pathway. EMBO J. 2008, 27 (2): 315-327.
Article
Google Scholar
Roemisch K: Endoplasmic Reticulum Associated Degradation. Annual Review of Cell and Developmental Biology. 2005, 21 (1): 435-456.
Article
Google Scholar
Pimpl P, Taylor JP, Snowden C, Hillmer S, Robinson DG, Denecke J: Golgi-Mediated Vacuolar Sorting of the Endoplasmic Reticulum Chaperone BiP May Play an Active Role in Quality Control within the Secretory Pathway. Plant Cell. 2006, 18 (1): 198-211.
Article
Google Scholar
Pagny S, Denmat-Ouisse LA, Gomord V, Faye L: Fusion with HDEL protects cell wall invertase from early degradation when N-glycosylation is inhibited. Plant Cell Physiol. 2003, 44 (2): 173-182.
Article
Google Scholar
de Virgilio M, De Marchis F, Bellucci M, Mainieri D, Rossi M, Benvenuto E, Arcioni S, Vitale A: The human immunodeficiency virus antigen Nef forms protein bodies in leaves of transgenic tobacco when fused to zeolin. J Exp Bot. 2008, 59 (10): 2815-2829.
Article
Google Scholar
Hadlington JL, Santoro A, Nuttall J, Denecke J, Ma JK-C, Vitale A, Frigerio L: The C-terminal Extension of a Hybrid Immunoglobulin A/G Heavy Chain Is Responsible for Its Golgi-mediated Sorting to the Vacuole. Mol Biol Cell. 2003, 14 (6): 2592-2602.
Article
Google Scholar
Nuttall J, Vine N, Hadlington JL, Drake P, Frigerio L, Ma JK-C: ER resident chaperone interactions with recombinant antibodies in transgenic plants. European Journal of Biochemistry. 2002, 269 (24): 6042-6051.
Article
Google Scholar
Gevaudant F, Duby G, von Stedingk E, Zhao R, Morsomme P, Boutry M: Expression of a Constitutively Activated Plasma Membrane H+-ATPase Alters Plant Development and Increases Salt Tolerance. Plant Physiol. 2007, 144 (4): 1763-1776.
Article
Google Scholar
Delannoy Ml, Alves G, Vertommen D, Ma J, Boutry M, Navarre C: Identification of peptidases in Nicotiana tabacum leaf intercellular fluid. Proteomics. 2008, 8 (11): 2285-2298.
Article
Google Scholar
Schiermeyer A, Hartenstein H, Mandal M, Otte B, Wahner V, Schillberg S: A membrane-bound matrix-metalloproteinase from Nicotiana tabacum cv. BY-2 is induced by bacterial pathogens. BMC Plant Biology. 2009, 9 (1): 83-
Article
Google Scholar
Müntz K, Shutov AD: Legumains and their functions in plants. Trends in Plant Science. 2002, 7 (8): 340-344.
Article
Google Scholar
Pedrazzini E, Giovinazzo G, Bielli A, de Virgilio M, Frigerio L, Pesca M, Faoro F, Bollini R, Ceriotti A, Vitale A: Protein quality control along the route to the plant vacuole. Plant Cell. 1997, 9 (10): 1869-1880.
Article
Google Scholar