Figure 8
From: Physicochemical and biological characterization of 1E10 Anti-Idiotype vaccine
Antitumor effects of 1E10-AF/Alum and 1E10-ST/Alum co-administrated with low-dose Cyclophosphamide in a mammary carcinoma model. F3II tumor-bearing mice were immunized subcutaneously with 100 μg of 1E10-ST/Alum alone (open triangle); 1E10-AF/Alum (open circle) or 1E10-ST/Alum (open square) combined with 150 mg/m2 of Cyclophosphamide i.v. 7 days after the tumor inoculation. Both combinations reduced significantly the F3II mammary carcinoma growth. This response was comparable with the administration of high-dose chemotherapy based on 60 mg/m2 of Doxorubicin and 600 mg/m2 of Cyclophosphamide (full triangle). * Significant differences (P < 0.05) using Kruskal-Wallis and Dunn's multiple comparison tests.