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Fig. 3 | BMC Biotechnology

Fig. 3

From: Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

Fig. 3

Polyphyllin B regulated CSE and LPS-induced oxidative stress, mitochondrial damage and ferritinophagy in mice. A Prussian blue staining. B and C The expressions of ferritin, NCOA4, p-STAT3, and GPX4 in lung tissue were detected by western blot. Full-length blots/gels are presented in Supplementary Fig. 2B and C. D The expression of 4-HNE in lung tissue was detected by immunohistochemistry. E The levels of ROS and nitrotyrosine in peripheral blood and lung tissue were detected by ELISA. F TEM images showed the changes of mitochondria in lung tissues. *P < 0.05 vs Control, #P < 0.05 vs C + L. N = 6 mice/group

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BMC Biotechnology

ISSN: 1472-6750

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