Table 2 Technological characteristics of the PLGA-VAN formulation: average diameter, PDI and zeta potential throughout stability study, (means ± SD, n = 3)
Formulation | Technological parameters | Time (months) | |||||
|---|---|---|---|---|---|---|---|
0 | 2 | 4 | 6 | 8 | 12 | ||
PLGA-VAN-LYS (F4) | Size (nm) | 320.5 ± 35 | 322.5 ± 32 | 326.3 ± 25 | 332.8 ± 34 | 420.4 ± 42 | 495.5 ± 34 |
PDI | 0.270 ± 0.012 | 0.270 ± 0.017 | 0.274 ± 0.010 | 0.278 ± 0.014 | 0.285 ± 0.012 | 0.290 ± 0.011 | |
ZPa (mV) | -19.5 ± 1.3 | -19.2 ± 3.8 | -18.9 ± 2.1 | -18.5 ± 2.3 | -17.9 ± 3.4 | -17.5 ± 3.8 | |