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Fig. 1 | BMC Biotechnology

Fig. 1

From: Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

Fig. 1

Solubility of lamotrigine in simulated (A) fasted-state gastric media, (B) fed-state gastric media, (C) fasted-state intestinal, and (D) fed-state intestinal media. Ns: not significant, *: p-value < 0.05, **: p-value < 0.01, ***: p-value < 0.001, ****: p-value < 0.0001. FaSSGF: fasted-state simulated gastric fluid; Pn-FaSSGF: pediatric fasted-state gastric media representative of neonates (birth to 27 days); Pi-FaSSGF: pediatric fasted-state gastric media representative of infants (1–12 months); FeSSGF: fed-state simulated intestinal fluid; Pnc-FeSSGF: pediatric fed-state gastric media representative of neonates (birth to 27 days)fed milk-based formula; Pns-FeSSGF: pediatric fed-state gastric media representative of neonates (birth to 27 days) fed soy-based formula; FaSSIF.v2: fasted-state simulated intestinal fluid; P-FaSSIF-50%: pediatric fasted-state intestinal media formulated with bile salt concentrations 50% (i.e., 1.5 mM) of adult levels; P-FaSSIF-150%: pediatric fasted-state intestinal media formulated with bile salt concentrations 150% (i.e., 4.5 mM) of adult levels; FeSSIF.v2: fed-state simulated gastric fluid; Pnb-FeSSIF: pediatric fed-state intestinal media representative of neonates (birth to 27 days) fed breast milk; Pnc-FeSSIF: pediatric fed-state intestinal media representative of neonates (birth to 27 days) fed milk-based formula; Pi-FeSSIF: pediatric fed-state intestinal media representative of infants (1–12 months) fed milk-based formula

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BMC Biotechnology

ISSN: 1472-6750

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