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Table 2 The results of SPR analysis for Asp. IL-1Ra and Anakinra (Kineret®)

From: Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system

 

Parameters

Sample

ka × 10–4 (1/Ms)

kd × 104 (1/s)

Kd × 102 (nM)

Asp. IL-1Ra

9.3

1.9

206.2

Anakinra

424.6

1.4

3.46

  1. ka on-rate, kd off-rate, Kd binding affinity