A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

Table 1 Primers for mutation of scFv B2 V_H-CDR3

Sense	5’-ATATATTACTGTGCGAGANNSGGGNNSNNSATGGACGTCTGGGGCCAGGG-3’
Anti-sense	5’- CGCACAGTAATATATGGCGGTGTCCGAGGCCTTCAGGCTGCTCCACT-3’

NNS codon (N randomizing with all four nucleotides and S introducing only C or G)

ISSN: 1472-6750