Fig. 6

NOMe-Seq of IMR-90 cells. A–D Comparisons of DNA methylation levels between CCMT-treated and untreated nuclei. Intrinsic DNA methylation at the CG sites (A and B) and methylation at CC sites introduced via CCMT in vitro (C and D) are shown. E Genome browser screenshots showing annotated human genes (Track 1), intrinsic methylation levels (Track 2, 3, and 4 for untreated, CCMT-treated, and GCMT-treated ones, respectively), MTase-induced methylations (Track 5, 6, and 7 for untreated, CCMT-treated, and GCMT-treated, respectively), and read coverage of ATAC-Seq (SRR7765313) are shown (Track 8). The right panel is the enlarged view of the indicated location of the left panel. For the tracks showing MTase-induced methylation patterns (Track 5, 6, and 7), peaks detected with macs2 are indicated at the bottom of each track