Table 3 The material properties of the tumor and normal tissues [6, 17]
From: Computational modeling of PET tracer distribution in solid tumors integrating microvasculature
Parameter | Symbol [unit] | Value |
|---|---|---|
Plasma osmotic pressure | \(\pi_{b}\)[mmHg] | 20 |
Interstitial fluid osmotic pressure | \(\pi_{i}\)[mmHg] | 10 (Normal tissue) 15 (Tumor tissue) |
Average osmotic reflection coefficient | \(\sigma_{s}\)[−] | 0.91 (Normal tissue) 0.82 (Tumor tissue) |
Hydraulic conductivity of the microvascular wall | \(L_{p}\)[cm/((mmHg) s)] | 0.36e−7 (Normal tissue) 2.8e−7 (Tumor tissue) |
Interstitial hydraulic conductivity | \(\kappa\)[m2/(Pa s)] | 6.41e−15 (Normal tissue) 30.0e−15 (Tumor tissue) |
Lymphatic filtration coefficient | LpL(S/V)L [1/(mmHg s)] | 1.33e−5 (Normal tissue) 0 (Tumor tissue) |
Hydrostatic pressure of lymphatic vessels | PL [Pa] | 0 |