Fig. 3

Functional validation of potential candidate genes. a Wild-type and Adam17-sgRNA infected cells were sequenced to validate the mutation in Adam17 gene. b CommaDβ cells were infected with individual lentiviral gRNA of Ctrl, Adam17, Fam159a, 2310035C23Rik, Pif1, Serpina3c. In the third passage, only cells with Adam17 gRNA had a significant Procr⁺ population