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Table 5 Summary of recent reports of fibrinolytic enzyme expression in the literature

From: An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Wild-type strain Host (strains/plasmids) Fibase activity References
Paenibacillus polymyxa EJS-3 E. coli BL21 (DE3)/pET-DsbA 228.0 U/ml [8] (Lv et al. 2015)
Bacillus amyloliquefaciens B. subtilis WB600/pSUGV4 200.0 U/ml [46] (Xiao et al. 2004)
Bacillus pumilus BS15 B. subtilis WB600 /pHY300PLK 408.2 U/ml [47] (Yao et al. 2018)
Bacillus pumilus BS15 none 242.5 U/ml [47] (Yao et al. 2018)
Xanthomonas oryzae IND3 none 2294 ± 12.8 U/g [48] (Vijayaraghavan et al. 2019)
Serratia KG-2-1 none 250.4 U/ml [9] (Taneja et al. 2017)
Serratia rubidaea none 394.9 U/ml [49] (Anusree et al. 2020)
Bacillus sp. IND12 none 4143 U/g [50] (Vijayaraghavan et al. 2017)
Cordyceps militaris none 120.0 U/ml [51] (Liu et al. 2017)
B. subtilis D21 none 279 U/ml This research
B. subtilis D21 K. phaffii GS115 /pPIC9K 7930/12690 U/ml This research