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Table 4 The cytokine levels of splenocytes extracted from mice after a lethal challenge with Legionella pneumophila

From: Recombinant PAL/PilE/FlaA DNA vaccine provides protective immunity against Legionella pneumophila in BALB/c mice

  L.p-control L.p-pcDNA3.1 L.p-PAL/PiLE/FLaA
TNF-α 12 h 28.464 ± 3.656 30.544 ± 3.160 66.426 ± 6.966***
24 h 63.061 ± 6.975 66.022 ± 7.707 142.812 ± 18.872***
48 h 74.966 ± 8.033 79.856 ± 8.523 155.792 ± 16.642***
72 h 71.350 ± 7.257 78.119 ± 8.014 176.366 ± 19.816***
IFNγ 12 h 17.882 ± 2.151 18.063 ± 1.958 168.855 ± 17.771***
24 h 42.829 ± 6.708 41.573 ± 6.185 259.489 ± 31.379***
48 h 27.588 ± 4.677 28.726 ± 5.612 361.732 ± 39.412***
72 h 32.878 ± 3.567 35.138 ± 4.788 442.975 ± 51.127***
IL-10 12 h 35.905 ± 5.921 38.285 ± 6.257 638.272 ± 72.853***
24 h 26.358 ± 2.762 25.189 ± 3.560 597.381 ± 70.460***
48 h 18.722 ± 2.776 18.359 ± 3.338 580.414 ± 71.515***
72 h 23.453 ± 4.065 22.517 ± 4.267 464.455 ± 47.797***
12 h 7.545 ± 0.848 7.866 ± 0.832 166.512 ± 19.016***
24 h 9.129 ± 1.099 9.616 ± 1.083 153.189 ± 16.667***
IL-4 48 h 16.399 ± 2.269 18.371 ± 2.041 180.543 ± 20.530***
72 h 19.566 ± 2.546 21.151 ± 3.770 182.311 ± 23.732***
12 h 32.346 ± 3.307 31.066 ± 3.123 187.781 ± 24.391***
24 h 25.581 ± 2.879 24.311 ± 2.506 263.204 ± 38.746***
IL-12 48 h 21.841 ± 2.484 22.015 ± 2.566 360.088 ± 60.515***
72 h 27.231 ± 3.618 27.220 ± 3.528 439.624 ± 50.110***
  1. ***, p < 0.001 versus the L.p-pcDNA3.1 group