Fig. 5
From: A self-aggregating peptide: implications for the development of thermostable vaccine candidates
The antibody response to GFP induced by the polyehedrin particles suggests a Th1 and Th2 profile. After 8 weeks when the immune response was established immunoglobulin G subtypes were evaluated by ELISA; a IgG2a, b IgG2b and c IgG1 showing no significant difference between the groups: GFP + Alum, PH(1–110) GFP and PH(1–110) GFP + Alum, but these groups had at least a p-value < 0.05 against the PBS + Alum and GFP groups. d The IgG2a/IgG1 ratio was obtained to determine the type of predominant profile (Th1 or Th2) of the immune response generated by the PH(1–110) GFP particles. Error bars indicate the means ± SD (n = 5). *** p < 0.001; ns = not significant. (Two-way ANOVA with Tukey post-tests)