Fig. 6
The schematic diagram of transcription regulation in Mxr1-reprogrammed cells. There are two phases, derepression and activation, for PAOX1 activation in P. pastoris. Prm1, Mit1, and Mxr1 are activators (blue). Nrg1 and X are repressors (red). The dashed line and repressor X are speculated based on our results, for which further investigation is needed. In reprogrammed cells, we used PAOX2 to express extra Mxr1 (dark blue square)