Organic solvent | Log P
a
| Partition coefficientb
| Yield (%) |
ee (%) |
|---|
COBE | CHBE |
|---|
n-Butanol | 0.839 | 2.6c
| 1.8c
| 37.7 | >99 |
tert-Amylalcohol | 1.094 | 3.3c
| 2.9c
| 39.4 | >99 |
MTBE | 1.296 | 8.9c
| 4.8c
| 48.1 | >99 |
Butyl acetate | 1.804 | 10.6 | 15.8 | 12.8 | >99 |
Toluene | 2.27 | 21.3 | 2.8 | 44.1 | >99 |
Octanol | 2.876 | 5.3 | 3.8 | 86.6 | >99 |
-
aCalculated using Advanced Chemistry Development (ACD/Labs) Software V11.02
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bPartition coefficient is the molar ratio of each compound found in the organic phase to the same compound in the aqueous phase (data from ref. [18, 46, 47])
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cCOBE (73.9 μmol) and CHBE (71.2 μmol) in 0.7 mL phosphate buffer (100 mM, 6.5) were shaken with organic solvents (0.7 mL) at 30 °C in an eppendorf tube. The concentrations of COBE and CHBE in each phase were determined by GC analysis
