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Fig. 6 | BMC Biotechnology

Fig. 6

From: An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin

Fig. 6

Immunogenicity of fusion protein. Groups of C3H/HeJ mice (n = 6) were vaccinated i.p. with three doses of HA1-2, HA1-2-fliC, or PBS on days 0, 14, and 28. The animals were bled 12 days following the second and third immunization. Antibody titers were measured by ELISA or HAI assay. a HA1-2-specific IgG titers. Serum samples of each group were collected at 12 days post-second and -third immunization (on days 26 and 40). b HA1-2-specific IgG subtype (IgG1, IgG2a) titers. Serum samples of each group were collected at 12 days post-third immunization (on day 40). c HAI titers. Serum samples of each group were collected at 12 days post-third immunization (on day 40). d The longevity of HA1-2-specific IgG. Serum samples of each group were collected for 3 months at 12-day intervals after the third immunization (days post-third immunization, d.p.3rd.i). All Data are presented as mean ± SEM; *p < 0.05, **p < 0.01, *** p < 0.001

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BMC Biotechnology

ISSN: 1472-6750

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