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Figure 10 | BMC Biotechnology

Figure 10

From: Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency loss

Figure 10

Modeling of the TM and CT domains in the HA trimer. The top shows the amino acid sequence of the carboxy terminus (TM and CT domains) for H3 A/Perth HA with the TM and CT cysteines highlighted in yellow (top line), and the 7 possible orientations of that sequence in a helix with the interfacial positions highlighted in pink (A and D). The schematics depict the trimer configuration (each monomer is represented by a seven pointed helical wheel) with 7 positions labeled A through G on the bottom left and one possible configuration (orientation 2) on the bottom right.

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BMC Biotechnology

ISSN: 1472-6750

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