Figure 7

Transcriptional profiling data comparing the production strategies. (A) Volcano plots of the combined triplicate RNA microarray data at the points of highest interest, 22 and 27 hours showing the spread of gene expression events in terms of up and down regulation between each production strategy comparison. (B) A table showing the transcriptional changes exceeding the 2-fold change threshold for each comparison and also listed by gene category throughout the cultivations. The total number of hits shows the combined number of transcriptional changes for all of the production strategies and the final column shows the mutual transcriptional changes observed between secretion and intracellular production. In the case of intracellular production most of these transcriptional changes observed are also found in the mutual category showing that many similar genes are highlighted between both types of production.