Figure 3From: Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californicaGP64 and Sendai virus F2 domainMicroscopic detection of GFP expression in the liver. Expression of GFP in the liver following portal vein injection of either wtGP64, Sendai-GP64/wtGP64, or Sendai-spGP64/wtGP64 lentiviral vectors. Sections from the livers of (A) control (B) wild type GP64, (C) Sendai-GP64/wtGP64, (D) Sendai-spGP64/wtGP64 transduced mice. Low magnification (10×) fields are shown to give a representative view. White arrows indicate hepatocytes and yellow arrows indicate nonparenchymal liver cells. In wild type GP64 injected mice most GFP positive cells are nonparenchymal, in Sendai-GP64/wtGP64 injected mice the proportion of GFP positive nonparenchymal cells is much lower.Back to article page