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Table 3 Quality of life assessment for GHRH-treated dogs.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment Day 0 Day 20 Day 40 Day 60
Overall QOL Average score
n
% change
P-value vs. Day 0 		3.08 ± 0.05
n = 26 		3.43 ± 0.18*
n = 23
11.63%
0.06 		3.39 ± 0.20
n = 18
10.14%
0.10 		3.71 ± 0.17
n = 17
20.44%
0.0005
Body Weight Average score
n
% change
P-value vs. Day 0 		3.0 ± 0.0
n = 28 		3.0 ± 0.11
n = 19
0.0%
0.5 		3.13 ± 0.20
n = 16
4.17%
0.27 		3.18 ± 0.15
n = 17
5.88%
0.14
Activity Level Average score
n
% change
P-value vs. Day 0 		2.97 ± 0.08
n = 29 		3.52 ± 0.19
n = 23
18.76%
0.02 		3.32 ± 0.19
n = 22
11.89%
0.03 		3.67 ± 0.14
n = 18
23.64%
0.0001
Exercise Tolerance Average score
n
% change
P-value vs. Day 0 		3.07 ± 0.07
n = 29 		3.21 ± 0.14
n = 23
4.84%
0.19 		3.32 ± 0.19
n = 22
8.12%
0.10 		3.72 ± 0.16
n = 18
21.29%
0.0003
Mentation Average score
n
% change
P-value vs. Day 0 		3.14 ± 0.08
n = 29 		3.43 ± 0.15
n = 23
9.46%
0.10 		3.14 ± 0.20
n = 21
0.16%
0.5 		3.47 ± 0.18
n = 17
10.60%
0.052
Appetite Average score
n
% change
P-value vs. Day 0 		2.98 ± 0.07
n = 29 		3.48 ± 0.19
n = 23
16.61%
0.01 		3.19 ± 0.21
n = 21
6.96%
0.24 		3.24 ± 0.18
n = 17
8.47%
0.07
Thirst Average score
n
% change
P-value vs. Day 0 		3.0 ± 0.0
n = 29 		3.13 ± 0.14
n = 23
4.35
0.19 		3.05 ± 0.15
n = 21
1.56%
0.37 		3.0 ± 0.08
n = 18
0%
0.5
Urination Frequency Average score
n
% change
P-value vs. Day 0 		3.0 ± 0.0
n = 29 		3.04 ± 0.13
n = 23
1.45%
0.37 		2.95 ± 0.11
n = 21
-1.59%
0.33 		3.11 ± 0.08
n = 18
3.70%
0.08
Bowel Movement Frequency Average score
n
% change
P-value vs. Day 0 		3.04 ± 0.04
n = 28 		3.09 ± 0.15
n = 23
1.69%
0.29 		3.0 ± 0.12
n = 21
-1.18%
0.5 		3.0 ± 0.0
n = 18
-1.18%
NS
Diarrhea Frequency Average score
n
% change
P-value vs. Day 0 		3.10 ± 0.06
n = 29 		3.0 ± 0.0
n = 23
-3.33%
NS 		3.05 ± 0.05
n = 21
-1.80%
0.16 		3.0 ± 0.0
n = 18
-3.33%
0.17
Vomiting Frequency Average score
n
% change
P-value vs. Day 0 		3.07 ± 0.05
n = 29 		2.96 ± 0.04
n = 23
-3.66%
0.04 		3.05 ± 0.05
n = 21
-0.70%
0.29 		3.03 ± 0.03
n = 18
-1.34%
0.09
  1. Abbreviations: NS, not significant Quality of life parameters from day 0 to day 60 of study where 1 = significantly decreased, 2 = decreased, 3 = no change, 4 = increased and 5 = significantly increased. For each parameter, data are presented as average ± SEM. Percentage changes over baseline values, as well as P value versus baseline values is included for each parameter at each time point.
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BMC Biotechnology

ISSN: 1472-6750

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