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Table 3 Quality of life assessment for GHRH-treated dogs.
From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals
| Assessment | Day 0 | Day 20 | Day 40 | Day 60 | |
|---|---|---|---|---|---|
| Overall QOL |
Average score n % change P-value vs. Day 0 |
3.08 ± 0.05 n = 26 |
3.43 ± 0.18* n = 23 11.63% 0.06 |
3.39 ± 0.20 n = 18 10.14% 0.10 |
3.71 ± 0.17
n = 17 20.44% 0.0005 |
| Body Weight |
Average score n % change P-value vs. Day 0 |
3.0 ± 0.0 n = 28 |
3.0 ± 0.11 n = 19 0.0% 0.5 |
3.13 ± 0.20 n = 16 4.17% 0.27 |
3.18 ± 0.15 n = 17 5.88% 0.14 |
| Activity Level |
Average score n % change P-value vs. Day 0 |
2.97 ± 0.08 n = 29 |
3.52 ± 0.19
n = 23 18.76% 0.02 |
3.32 ± 0.19
n = 22 11.89% 0.03 |
3.67 ± 0.14
n = 18 23.64% 0.0001 |
| Exercise Tolerance |
Average score n % change P-value vs. Day 0 |
3.07 ± 0.07 n = 29 |
3.21 ± 0.14 n = 23 4.84% 0.19 |
3.32 ± 0.19 n = 22 8.12% 0.10 |
3.72 ± 0.16
n = 18 21.29% 0.0003 |
| Mentation |
Average score n % change P-value vs. Day 0 |
3.14 ± 0.08 n = 29 |
3.43 ± 0.15 n = 23 9.46% 0.10 |
3.14 ± 0.20 n = 21 0.16% 0.5 |
3.47 ± 0.18 n = 17 10.60% 0.052 |
| Appetite |
Average score n % change P-value vs. Day 0 |
2.98 ± 0.07 n = 29 |
3.48 ± 0.19
n = 23 16.61% 0.01 |
3.19 ± 0.21 n = 21 6.96% 0.24 |
3.24 ± 0.18 n = 17 8.47% 0.07 |
| Thirst |
Average score n % change P-value vs. Day 0 |
3.0 ± 0.0 n = 29 |
3.13 ± 0.14 n = 23 4.35 0.19 |
3.05 ± 0.15 n = 21 1.56% 0.37 |
3.0 ± 0.08 n = 18 0% 0.5 |
| Urination Frequency |
Average score n % change P-value vs. Day 0 |
3.0 ± 0.0 n = 29 |
3.04 ± 0.13 n = 23 1.45% 0.37 |
2.95 ± 0.11 n = 21 -1.59% 0.33 |
3.11 ± 0.08 n = 18 3.70% 0.08 |
| Bowel Movement Frequency |
Average score n % change P-value vs. Day 0 |
3.04 ± 0.04 n = 28 |
3.09 ± 0.15 n = 23 1.69% 0.29 |
3.0 ± 0.12 n = 21 -1.18% 0.5 |
3.0 ± 0.0 n = 18 -1.18% NS |
| Diarrhea Frequency |
Average score n % change P-value vs. Day 0 |
3.10 ± 0.06 n = 29 |
3.0 ± 0.0 n = 23 -3.33% NS |
3.05 ± 0.05 n = 21 -1.80% 0.16 |
3.0 ± 0.0 n = 18 -3.33% 0.17 |
| Vomiting Frequency |
Average score n % change P-value vs. Day 0 |
3.07 ± 0.05 n = 29 |
2.96 ± 0.04 n = 23 -3.66% 0.04 |
3.05 ± 0.05 n = 21 -0.70% 0.29 |
3.03 ± 0.03 n = 18 -1.34% 0.09 |
