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Table 3 Quality of life assessment for GHRH-treated dogs.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment Day 0 Day 20 Day 40 Day 60
Overall QOL Average score n % change P-value vs. Day 0 3.08 ± 0.05 n = 26 3.43 ± 0.18* n = 23 11.63% 0.06 3.39 ± 0.20 n = 18 10.14% 0.10 3.71 ± 0.17 n = 17 20.44% 0.0005
Body Weight Average score n % change P-value vs. Day 0 3.0 ± 0.0 n = 28 3.0 ± 0.11 n = 19 0.0% 0.5 3.13 ± 0.20 n = 16 4.17% 0.27 3.18 ± 0.15 n = 17 5.88% 0.14
Activity Level Average score n % change P-value vs. Day 0 2.97 ± 0.08 n = 29 3.52 ± 0.19 n = 23 18.76% 0.02 3.32 ± 0.19 n = 22 11.89% 0.03 3.67 ± 0.14 n = 18 23.64% 0.0001
Exercise Tolerance Average score n % change P-value vs. Day 0 3.07 ± 0.07 n = 29 3.21 ± 0.14 n = 23 4.84% 0.19 3.32 ± 0.19 n = 22 8.12% 0.10 3.72 ± 0.16 n = 18 21.29% 0.0003
Mentation Average score n % change P-value vs. Day 0 3.14 ± 0.08 n = 29 3.43 ± 0.15 n = 23 9.46% 0.10 3.14 ± 0.20 n = 21 0.16% 0.5 3.47 ± 0.18 n = 17 10.60% 0.052
Appetite Average score n % change P-value vs. Day 0 2.98 ± 0.07 n = 29 3.48 ± 0.19 n = 23 16.61% 0.01 3.19 ± 0.21 n = 21 6.96% 0.24 3.24 ± 0.18 n = 17 8.47% 0.07
Thirst Average score n % change P-value vs. Day 0 3.0 ± 0.0 n = 29 3.13 ± 0.14 n = 23 4.35 0.19 3.05 ± 0.15 n = 21 1.56% 0.37 3.0 ± 0.08 n = 18 0% 0.5
Urination Frequency Average score n % change P-value vs. Day 0 3.0 ± 0.0 n = 29 3.04 ± 0.13 n = 23 1.45% 0.37 2.95 ± 0.11 n = 21 -1.59% 0.33 3.11 ± 0.08 n = 18 3.70% 0.08
Bowel Movement Frequency Average score n % change P-value vs. Day 0 3.04 ± 0.04 n = 28 3.09 ± 0.15 n = 23 1.69% 0.29 3.0 ± 0.12 n = 21 -1.18% 0.5 3.0 ± 0.0 n = 18 -1.18% NS
Diarrhea Frequency Average score n % change P-value vs. Day 0 3.10 ± 0.06 n = 29 3.0 ± 0.0 n = 23 -3.33% NS 3.05 ± 0.05 n = 21 -1.80% 0.16 3.0 ± 0.0 n = 18 -3.33% 0.17
Vomiting Frequency Average score n % change P-value vs. Day 0 3.07 ± 0.05 n = 29 2.96 ± 0.04 n = 23 -3.66% 0.04 3.05 ± 0.05 n = 21 -0.70% 0.29 3.03 ± 0.03 n = 18 -1.34% 0.09
  1. Abbreviations: NS, not significant Quality of life parameters from day 0 to day 60 of study where 1 = significantly decreased, 2 = decreased, 3 = no change, 4 = increased and 5 = significantly increased. For each parameter, data are presented as average ± SEM. Percentage changes over baseline values, as well as P value versus baseline values is included for each parameter at each time point.