Figure 2
From: Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
Release characteristics of HCPT from PEG-PBLG nanoparticles in vitro in different buffers. The HCPT release profile was biphasic with an initial abrupt release, followed by sustained release. The abrupt release occurred at 2 h and 1/3 of the loaded-HCPT was released during this period. Then, the HCPT entered the sustained release; after 96 h, 3/5 of the loaded-HCPT was still enwrapped in the nanoparticles. In this release study, HCPT-loaded nanoparticles also showed a quick release pattern in the alkaline condition.