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Figure 1 | BMC Biotechnology

Figure 1

From: Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of mdx mice

Figure 1

Dystrophin induction in limb musculature of mdx mice after intramuscular injections of 2'OMe ESO complexed with cationic nanopolymers. The TA muscles of mdx mice were given 3 weekly intramuscular injections of various PEG-PEI copolymers complexed with 5 μg of ESO and harvested 3 wks after the first injection. Dystrophin immunolabeling (Hoechst dye counterstained) at 2 different magnifications and H&E staining of serial transverse sections from TA muscles from the following groups: (A-A") normal age-matched controls, (B-B") mdx untreated, (C-C") mdx injected with PEI2K(PEG550)10-ESO, (D-D") mdx injected with NG-PEI2K(PEG550)10-ESO, and (E-E") mdx injected with CG-PEI2K(PEG5K)10-ESO.

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BMC Biotechnology

ISSN: 1472-6750

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