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Figure 1 | BMC Biotechnology

Figure 1

From: Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Figure 1

Oligosaccharide fucosylation and GDP-fucose synthesis in mammalian cells. In mammalian cells, GDP-fucose is synthesized via two distinct pathways, the de novo and salvage pathways. The transport of GDP-fucose into the Golgi apparatus, where the fucosyltransferases are located, is accomplished by a GDP-fucose transporter.

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BMC Biotechnology

ISSN: 1472-6750

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