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Table 3 Performance comparison of Q-plexand individual-target ELISA assays for the detection of bladder cancer in urine samples

From: Simultaneous multi-analyte urinary protein assay for bladder cancer detection

Urinary analytes Assay platform AUROC [95% CI] Sensitivity (%) Specificity (%) PPV (%) NPV (%)
IL8 Q-Plex™ Array 0.907 [0.830 - 0.985] 90 86 82 92
  Commercial ELISA 0.878 [0.783 - 0.972] 87 86 82 90
MMP9 Q-Plex™ Array 0.533 [0.392 - 0.674] 45 76 58 65
  Commercial ELISA 0.548 [0.409 - 0.688] 45 76 58 65
VEGFA Q-Plex™ Array 0.524 [0.386 - 0.661] 17 95 71 61
  Commercial ELISA 0.493 [0.356 - 0.630] 16 95 71 61
Combination Q-Plex™ Array 0.948 [0.903 - 0.992] 93 81 78 94
  Commercial ELISA 0.912 [0.796 - 0.968] 77 91 86 84