Table 3 Performance comparison of Q-plex™ and individual-target ELISA assays for the detection of bladder cancer in urine samples
From: Simultaneous multi-analyte urinary protein assay for bladder cancer detection
Urinary analytes | Assay platform | AUROC [95% CI] | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
IL8 | Q-Plex™ Array | 0.907 [0.830 - 0.985] | 90 | 86 | 82 | 92 |
Commercial ELISA | 0.878 [0.783 - 0.972] | 87 | 86 | 82 | 90 | |
MMP9 | Q-Plex™ Array | 0.533 [0.392 - 0.674] | 45 | 76 | 58 | 65 |
Commercial ELISA | 0.548 [0.409 - 0.688] | 45 | 76 | 58 | 65 | |
VEGFA | Q-Plex™ Array | 0.524 [0.386 - 0.661] | 17 | 95 | 71 | 61 |
Commercial ELISA | 0.493 [0.356 - 0.630] | 16 | 95 | 71 | 61 | |
Combination | Q-Plex™ Array | 0.948 [0.903 - 0.992] | 93 | 81 | 78 | 94 |
Commercial ELISA | 0.912 [0.796 - 0.968] | 77 | 91 | 86 | 84 |