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Table 3 Performance comparison of Q-plexand individual-target ELISA assays for the detection of bladder cancer in urine samples

From: Simultaneous multi-analyte urinary protein assay for bladder cancer detection

Urinary analytes

Assay platform

AUROC [95% CI]

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

IL8

Q-Plex™ Array

0.907 [0.830 - 0.985]

90

86

82

92

 

Commercial ELISA

0.878 [0.783 - 0.972]

87

86

82

90

MMP9

Q-Plex™ Array

0.533 [0.392 - 0.674]

45

76

58

65

 

Commercial ELISA

0.548 [0.409 - 0.688]

45

76

58

65

VEGFA

Q-Plex™ Array

0.524 [0.386 - 0.661]

17

95

71

61

 

Commercial ELISA

0.493 [0.356 - 0.630]

16

95

71

61

Combination

Q-Plex™ Array

0.948 [0.903 - 0.992]

93

81

78

94

 

Commercial ELISA

0.912 [0.796 - 0.968]

77

91

86

84