Figure 1

Theoretical analysis of FD006 to bind VEGF. A: The amino acid residues and CDR region classification of FD006 (versus Avastin/bevacizumab); B: The 3-D structure of variable region in FD006 using computer-guided homology modeling and molecular dynamics methods. The yellow ribbon denoted the light chain variable region and the red ribbon denoted the heavy chain variable region; C: The 3-D complex structure of FD006 variable region and VEGFA obtained from computer-guided molecular docking and dynamics methods. The upper red ribbon denoted VEGF, the lower left (blue) ribbon was FD006-VL and the lower right (green and yellow) denoted FD006-VH.