Figure 8
Survival of BALB/c mice injected intraperitoneally with WT D39 and a 3-h and an 8-h culture of IDM- ply (A) and - lytA (B). All of the inocula were approximately 102 CFU. The median survival time is indicated by the dashed line. Significant differences in the median survival time of mice injected with a 3-h IDM-ply (A) or -lytA (B) culture versus those for mice injected with an 8-h culture of the IDM- mutants are indicated by an asterisk (*) (*p = 0.031 (without antibiotic) versus **p = 0.037 (erm usage) in IDM-ply; ***p = 0.019 (without antibiotic) and ****p = 0.021(cat usage) in IDM-lytA). Significant differences between mice injected with 8-h WT D39 and those injected with 3-h IDM clones are indicated by a pilcrow (¶). (¶p < 0.001(without antibiotic) and ¶¶p = 0.006 (erm usage) when compared to the 3-h IDM-ply; ¶¶¶p = 0.045 (without antibiotic) when compared to the 3 h IDM-lytA).