Figure 1

The mevalonate pathway. The enzymes selected for gene expression analysis are shown at the corresponding steps of the pathway. The dashed lines indicate multicomponent pathways. ERG10 – acetyl-CoA acetyltransferase, ERG13 – 3-hydroxy-3-methylglutaryl-CoA synthase, human (HMGR) and yeast (HMG1, HMG2) 3-hydroxy-3-methylglutaryl-Co A reductase 1 and 2, FPP1 – farnesyl pyrophosphate synthase, ERG1 – squalene monooxygenase, ERG6 – delta(24)-sterol C-methyltransferase, ERG3 – C-5 sterol desaturase, COQ3 – 3,4-dihydroxy-5-hexaprenylbenzoatemethyltransferase, COQ2 – para-hydroxybenzoate-polyprenyl transferase, CAT5 – ubiquinone biosynthesis monooxygenase, BTS1 – geranylgeranyl diphosphate synthase, RER2 – cis-prenyltransferase, SEC59 – dolichol kinase.