| Bioluminescence imaging | Confocal endomicroscopy |
---|---|---|
Strength | Non-invasive | High spatial resolution |
 | Low background signals | Single cell imaging |
 | Highly specific for Luciferase activity | Cell morphology studies |
Weakness | Low spatial resolution | Invasive procedure |
 | Low cell numbers not detectable | Requires direct probe contact |
 | Limited tissue penetration | Autofluorescence reduces specificity |
 | Superior specificity | Superior spatial resolution |