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Table 1 Comparison of detection techniques

From: Multimodal in vivoimaging reveals limited allograft survival, intrapulmonary cell trapping and minimal evidence for ischemia-directed BMSC homing

 

Bioluminescence imaging

Confocal endomicroscopy

Strength

Non-invasive

High spatial resolution

 

Low background signals

Single cell imaging

 

Highly specific for Luciferase activity

Cell morphology studies

Weakness

Low spatial resolution

Invasive procedure

 

Low cell numbers not detectable

Requires direct probe contact

 

Limited tissue penetration

Autofluorescence reduces specificity

 

Superior specificity

Superior spatial resolution