Figure 1
From: A designer hyper interleukin 11 (H11) is a biologically active cytokine
(A) Amino acid (AA) sequence of the fusion protein H11 and (B) Schematic representation of tertiary structure of the fusion complex. (A) The N-terminal signal peptide is indicated by thick underline. The sequences of C-terminus of IL-11Rα and N-terminus of IL-11, which form natural linker are boldface. The arrow indicates the fusion site. (B) The Ig-like region (D1 domain) and cytokine binding domains (D2 and D3) of IL-11Rα are indicated. The three receptor binding sites of IL-11 are shown. IL-11 binds the IL-11Rα though site I, while site II and III are occupied by two gp130 molecules.