The therapeutic efficacy of proteins in established arthritis in mice. (A) Arthritis scores of CIA mice (n = 5) during 21 days treatment. (B) Increment in paw swelling of CIA mice (n = 5) during 21 days treatment. Day 1 corresponds to the first day that clinical arthritis was found. The upward arrows mean the day when the proteins were administrated. Data are expressed as mean ± SEM. * = p < 0.05 and ** = p < 0.01 versus the clinical score and paw swelling of arthritic mice treatment with saline.