Table 2 Toxicity analysis of ADP 355
From: Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
Peptide dose (bolus ip) | Liver weight (g); relative to total weight (%) | Spleen weight (g) | Kidney weight (g); relative to total weight (%) |
|---|---|---|---|
Untreated | 0.98; 0.054 | 0.07 | 0.29; 0.015 |
5 mg/kg | 1.02; 0.054 | 0.07 | 0.30; 0.016 |
10 mg/kg | 1.09; 0.059 | 0.06 | 0.29; 0.016 |
25 mg/kg | 1.24; 0.059 | 0.07 | 0.35; 0.017 |
50 mg/kg | 1.07; 0.062 | 0.07 | 0.31; 0.017 |