Table 2 Maximal biomass and glutathione (TIG and TEG) production of H. polymorph a strains at different conditions of fermentation

177 ± 1.5

0.6

6

20 ± 0.15

1 ± 0.05

3.2 ± 0.26

Shake-

Glucose

200 rpm (w/o pH control)

380 ± 3.2

0.9

9

24 ± 0.19

1 ± 0.06

2.8 ± 0.19

flask

481 ± 3.9

1.0

10

27 ± 0.21

2 ± 0.09

2.8 ± 0.18

200 rpm (pH control 5.2)

161 ± 1.49

0.5

5

20 ± 1.4

2 ± 0.19

4.0 ± 0.36

Batch

600 rpm (- " - " - " - " - )

50 ± 0.45

0.3

3

17 ± 1.19

12 ± 1.10

6.9 ± 0.42

Wild type DL-1

Fermenter

Glucose

200 rpm (w/o pH control)

373 ± 3.12

1.1

11

69 ± 6.49

2 ± 0.20

6.1 ± 0.39

800 rpm (- " - " - " - " - )

269 ± 2.11

0.6

6

49 ± 4.45

17 ± 1.59

7.7 ± 0.45

Wild type DL-1

Methanol

DO-stat 60%

136

0.8

8

676

37

90

Wild type DL-1

Glucose

DO- stat 60%

183

1.2

12

518

22

44

Wild type DL-1

Glucose

DO- stat 30%

315

1.3

13

910

4

72

mcMET4

Fed-batch

Glucose

(- " - " - " - " )

318

1.6

16

1318

6

82

mcGSH2

fermenter

Glucose

(- " - " - " - " )

755

2.0

20

1532

1

77

MOXp-GSH2

Glucose

(- " - " - " - " )

409

3.1

31

2257

13

72

MOXp-GSH2

Methanol

DO-stat 60%

243

2.1

21

1053

250

55