Figure 3

Course of a Pf MSP1 ₁₉ transgenic P. berghei infection in mice. Groups of 3 (experiment 1) or 4 (experiment 2) FcαRI transgenic (Tg) or nontransgenic (NTg) littermates were injected i.p. with a total dose of 1.5 mg human anti-PfMSP1₁₉ IgA (C1) or phosphate buffered saline (PBS). No significant differences were observed for either the course of parasitemia or weight loss in both experiments. Each point represents the geometric mean parasitemia or weight of mice in each group at the time after i.p. challenge with 5,000 parasitized erythrocytes. In experiment 2, the FcαRI-blocking mAb 2H8 was co-administered at the same time as the IgA into CD89 Tg animals.