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Table 2 Neutralizing activity and affinity of anti-VLY scFvs and the respective MAbs

From: Generation of recombinant single-chain antibodies neutralizing the cytolytic activity of vaginolysin, the main virulence factor of Gardnerella vaginalis

Anti VLY scFv and MAb

IC50, M

Kd, M

scFv 9B4 (VL-VH)

3.7 × 10-8

1.1 × 10-8

scFv 9B4 (VH-VL)

5.1 × 10-8

1.5 × 10-8

scFv 23A2 (VL-VH)

1.1 × 10-7

9.2 × 10-8

scFv 23A2 (VH-VL)

1.5 × 10-7

9.8 × 10-8

MAb 9B4

6.7 × 10-11

2.9 × 10-10

MAb 23A2

4.8 × 10-10

1.2 × 10-10

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BMC Biotechnology

ISSN: 1472-6750

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