Table 5 Dose-dependent phenotypic alteration in the embryos treated at 24 hpf.
From: Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors
Cpd | Embryo Number | Conc. | Pigment | Tail | Trunk |
|---|---|---|---|---|---|
DMSO | 11 | 0.1% | normal | all straight | all straight |
DAPT | 11 | 50 μM | decreased | 11/11 curved | 11/11 curved |
DAPT | 9 | 5 μM | decreased slightly | all straight | 1/9 deformed |
DAPT | 4 | 0.5 μM | normal | all straight | all straight |
Gleevec | 9 | 100 μM | decreased | all straight | all straight |
Gleevec | 7 | 10 μM | normal | 1/7 curved | 1/7 short |
Gleevec | 7 | 1 μM | normal | all straight | all straight |
AD28 | 14 | 100 μM | decreased slightly | all straight | all straight |
AD28 | 4 | 50 μM | normal | all straight | all straight |
AD94 | 8 | 100 μM | lighter | all edema | all edema |
AD94 | 4 | 50 μM | lighter | all straight | all straight |
AD95 | 7 | 100 μM | lighter | all curved | all bent, 5/7 edema |
AD95 | 4 | 50 μM | normal | all bent | all bent, 3/4 edema |
Untreated | 3 | normal | all straight | all straight |