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Table 5 Dose-dependent phenotypic alteration in the embryos treated at 24 hpf.

From: Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

Cpd Embryo Number Conc. Pigment Tail Trunk
DMSO 11 0.1% normal all straight all straight
DAPT 11 50 μM decreased 11/11 curved 11/11 curved
DAPT 9 5 μM decreased slightly all straight 1/9 deformed
DAPT 4 0.5 μM normal all straight all straight
Gleevec 9 100 μM decreased all straight all straight
Gleevec 7 10 μM normal 1/7 curved 1/7 short
Gleevec 7 1 μM normal all straight all straight
AD28 14 100 μM decreased slightly all straight all straight
AD28 4 50 μM normal all straight all straight
AD94 8 100 μM lighter all edema all edema
AD94 4 50 μM lighter all straight all straight
AD95 7 100 μM lighter all curved all bent, 5/7 edema
AD95 4 50 μM normal all bent all bent, 3/4 edema
Untreated 3   normal all straight all straight