Host Organism | Product | Design | Studied factors | Product increase | Reference |
---|---|---|---|---|---|
E. coli SHuffle T7 | Biomass (SU-INS) | PBD, CCD | C, N sources, inorganic salts, pH | 2.3X (shake flask), 5.9X (fermentor) | Present study |
E. coli BL21 (DE3) | Phytase | CCD | C, N sources, salt | 1.2X | [18] |
E. coli (ATCC no. 11303) | L-Asparaginase | OFAT, CCD | C, N sources, ions, inoculum age and size | 10X | [19] |
E. coli BL21 (DE3) | L-Asparaginase II | FFD, CCFD | C, N sources, ions | NA | [20] |
E. coli BL21 (DE3) | Streptokinase | PBD, CCD | C, N sources, ions | 7X | [21] |
E. coli | Dihydrolipohyl Dehydrogenase | CCFD | C, N sources, inorganic salts, pH | 1.2X (shake flask), 1.7X (fermentor) | [22] |
E. coli DH5α | Rheumatoid arthritis DNA vaccine | OFAT, PBD, BBD | C, N sources, salts, trace elements, pH, inoculum size, temperature | 51.9% | [23] |
E. coli MET-3 | L-Methionine | PBD, BBD | C, N sources, salts | 1.5X (shake flask), 6.4X (fermentor) | [24] |
E. coli BL21 (DE3) | Reteplase | BBD | Temperature, Agitation, pH | 2X | [25] |
E. coli Δwaaf | Colanic acid | FFD, CCD | C, N sources, inorganic salts | 12X | [26] |
E. coli BL21 (DE3) | γ-cyclodextrin glycosyltransferase | OFAT, PBD, Steepest ascent path, BBD | C, N sources, inorganic salts, pH | 2.83X | [27] |