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Table 3 The physiological parameters of rats after the nattokinase treatment

From: Heterologous expression of nattokinase from B. subtilis natto using Pichia pastoris GS115 and assessment of its thrombolytic activity

groups of rats

dosage of enzymes (IU/kg)

FDP (pg/mL)

D-dimer (ng/mL)

Positive control (vermis kinase)

10,000

5.12 ± 0.31

15.02 ± 2.36

High dosage

50,000

6.17 ± 0.32

17.85 ± 2.10

Medium dosage

10,000

4.36 ± 0.21

13.59 ± 1.29

Low dosage

2000

2.04 ± 0.06

8.42 ± 1.88

Negative control (physiologic saline)

0

1.84 ± 0.27

6.00 ± 0.87