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Fig. 6 | BMC Biotechnology

Fig. 6

From: Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models

Fig. 6

Cell-mediated immunity response induced by H7N9 VLP in chickens (n = 6 per group). Splenocytes isolated from chickens on day 40 after immunization were stimulated ex vivo with H7N9 VLPs, and the cell-mediated response was evaluated. a Splenic IFN-γ and (b) IL-4 mRNA levels were investigated using real-time PCR. By using flow cytometry, chickens receiving VLPs exhibit significantly higher ratio of splenic CD4+ / CD8+ cell count (c), indicating stronger T helper cell response induced by H7N9 VLP vaccination. Error bars are mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001

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BMC Biotechnology

ISSN: 1472-6750

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