Table 3 Quality of life assessment for GHRH-treated dogs.
From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals
Assessment | Day 0 | Day 20 | Day 40 | Day 60 | |
|---|---|---|---|---|---|
Overall QOL | Average score n % change P-value vs. Day 0 | 3.08 ± 0.05 n = 26 | 3.43 ± 0.18* n = 23 11.63% 0.06 | 3.39 ± 0.20 n = 18 10.14% 0.10 | 3.71 ± 0.17 n = 17 20.44% 0.0005 |
Body Weight | Average score n % change P-value vs. Day 0 | 3.0 ± 0.0 n = 28 | 3.0 ± 0.11 n = 19 0.0% 0.5 | 3.13 ± 0.20 n = 16 4.17% 0.27 | 3.18 ± 0.15 n = 17 5.88% 0.14 |
Activity Level | Average score n % change P-value vs. Day 0 | 2.97 ± 0.08 n = 29 | 3.52 ± 0.19 n = 23 18.76% 0.02 | 3.32 ± 0.19 n = 22 11.89% 0.03 | 3.67 ± 0.14 n = 18 23.64% 0.0001 |
Exercise Tolerance | Average score n % change P-value vs. Day 0 | 3.07 ± 0.07 n = 29 | 3.21 ± 0.14 n = 23 4.84% 0.19 | 3.32 ± 0.19 n = 22 8.12% 0.10 | 3.72 ± 0.16 n = 18 21.29% 0.0003 |
Mentation | Average score n % change P-value vs. Day 0 | 3.14 ± 0.08 n = 29 | 3.43 ± 0.15 n = 23 9.46% 0.10 | 3.14 ± 0.20 n = 21 0.16% 0.5 | 3.47 ± 0.18 n = 17 10.60% 0.052 |
Appetite | Average score n % change P-value vs. Day 0 | 2.98 ± 0.07 n = 29 | 3.48 ± 0.19 n = 23 16.61% 0.01 | 3.19 ± 0.21 n = 21 6.96% 0.24 | 3.24 ± 0.18 n = 17 8.47% 0.07 |
Thirst | Average score n % change P-value vs. Day 0 | 3.0 ± 0.0 n = 29 | 3.13 ± 0.14 n = 23 4.35 0.19 | 3.05 ± 0.15 n = 21 1.56% 0.37 | 3.0 ± 0.08 n = 18 0% 0.5 |
Urination Frequency | Average score n % change P-value vs. Day 0 | 3.0 ± 0.0 n = 29 | 3.04 ± 0.13 n = 23 1.45% 0.37 | 2.95 ± 0.11 n = 21 -1.59% 0.33 | 3.11 ± 0.08 n = 18 3.70% 0.08 |
Bowel Movement Frequency | Average score n % change P-value vs. Day 0 | 3.04 ± 0.04 n = 28 | 3.09 ± 0.15 n = 23 1.69% 0.29 | 3.0 ± 0.12 n = 21 -1.18% 0.5 | 3.0 ± 0.0 n = 18 -1.18% NS |
Diarrhea Frequency | Average score n % change P-value vs. Day 0 | 3.10 ± 0.06 n = 29 | 3.0 ± 0.0 n = 23 -3.33% NS | 3.05 ± 0.05 n = 21 -1.80% 0.16 | 3.0 ± 0.0 n = 18 -3.33% 0.17 |
Vomiting Frequency | Average score n % change P-value vs. Day 0 | 3.07 ± 0.05 n = 29 | 2.96 ± 0.04 n = 23 -3.66% 0.04 | 3.05 ± 0.05 n = 21 -0.70% 0.29 | 3.03 ± 0.03 n = 18 -1.34% 0.09 |