From: Engineering proteinase K using machine learning and synthetic genes
 | RR | Lasso | PLSR | SVMR | ||||
---|---|---|---|---|---|---|---|---|
Substitution | M | σ | M | σ | M | σ | M | σ |
S107D | -0.03 | 0.13 | 0.00 | 0.02 | -0.70 | 0.26 | -0.16 | 0.13 |
S123A | -1.00 | 0.13 | -0.41 | 0.35 | -1.42 | 0.23 | -0.93 | 0.14 |
I132V | 0.04 | 0.44 | 0.04 | 0.55 | 0.32 | 0.76 | -0.34 | 0.29 |
M145F | -1.46 | 0.19 | -2.27 | 0.49 | -1.98 | 0.32 | -1.58 | 0.20 |
Y151A | 1.18 | 0.23 | 0.91 | 0.23 | 1.66 | 0.37 | 0.91 | 0.15 |
V167I | -0.97 | 0.13 | -1.09 | 0.15 | -1.10 | 0.17 | -0.79 | 0.14 |
L180I | -0.23 | 0.15 | -0.05 | 0.10 | -0.35 | 0.19 | -0.36 | 0.13 |
Y194S | 0.27 | 0.20 | 0.00 | 0.01 | 0.94 | 0.73 | 0.01 | 0.14 |
A199S | -1.16 | 0.39 | -1.09 | 0.46 | -2.66 | 0.98 | -0.86 | 0.21 |
K208H | 0.28 | 0.15 | 0.07 | 0.12 | 0.52 | 0.18 | 0.36 | 0.17 |
R237N | -0.93 | 0.09 | -0.91 | 0.13 | -1.21 | 0.12 | -0.86 | 0.15 |
V267I | -0.48 | 0.11 | -0.32 | 0.14 | -0.68 | 0.13 | -0.16 | 0.12 |
S273T | 0.12 | 0.14 | 0.01 | 0.06 | 0.28 | 0.19 | -0.05 | 0.17 |
G293A | 1.95 | 0.13 | 2.24 | 0.14 | 2.10 | 0.17 | 1.70 | 0.13 |
K332R | 0.07 | 0.13 | -0.01 | 0.05 | 0.02 | 0.14 | 0.09 | 0.15 |
S337N | -0.02 | 0.14 | 0.03 | 0.09 | -0.20 | 0.15 | 0.03 | 0.14 |
P355S | -1.08 | 0.12 | -1.20 | 0.15 | -1.25 | 0.13 | -1.10 | 0.15 |
 | LPSVMR | LPBoostR | MR | ORMR | ||||
Substitution | M | σ | M | σ | M | σ | M | σ |
S107D | -0.01 | 0.20 | -0.02 | 0.21 | -0.35 | 0.24 | -0.35 | 0.24 |
S123A | -0.41 | 0.43 | -0.40 | 0.41 | 0.52 | 0.93 | 0.52 | 0.93 |
I132V | 0.22 | 0.69 | 0.18 | 0.56 | 2.61 | 0.91 | 2.61 | 0.91 |
M145F | -2.39 | 0.53 | -2.39 | 0.53 | -5.33 | 1.05 | -5.33 | 1.05 |
Y151A | 0.82 | 0.24 | 0.82 | 0.25 | 0.64 | 0.24 | 0.64 | 0.24 |
V167I | -0.99 | 0.24 | -0.98 | 0.23 | -1.63 | 0.24 | -1.63 | 0.24 |
L180I | -0.20 | 0.16 | -0.19 | 0.16 | 0.60 | 0.23 | 0.60 | 0.23 |
Y194S | -0.02 | 0.08 | 0.21 | 0.38 | 4.59 | 2.10 | 4.59 | 2.10 |
A199S | -0.49 | 0.33 | -0.73 | 0.54 | -4.92 | 2.03 | -4.92 | 2.03 |
K208H | 0.16 | 0.18 | 0.14 | 0.18 | 0.01 | 0.13 | 0.01 | 0.13 |
R237N | -0.96 | 0.29 | -0.96 | 0.29 | -1.59 | 0.57 | -1.59 | 0.57 |
V267I | -0.41 | 0.23 | -0.41 | 0.23 | -1.33 | 0.14 | -1.33 | 0.14 |
S273T | 0.19 | 0.33 | 0.15 | 0.28 | 0.96 | 0.58 | 0.96 | 0.58 |
G293A | 2.18 | 0.25 | 2.20 | 0.25 | 3.20 | 0.14 | 3.20 | 0.14 |
K332R | 0.12 | 0.19 | 0.14 | 0.21 | -0.33 | 0.13 | -0.33 | 0.13 |
S337N | 0.27 | 0.28 | 0.26 | 0.28 | 0.34 | 0.59 | 0.34 | 0.59 |
P355S | -1.34 | 0.35 | -1.35 | 0.34 | -1.95 | 0.57 | -1.95 | 0.57 |