Figure 4

Diagram depicting the ability of vectors containing multiple siRNA expression cassettes to simultaneously suppress the expression of multiple genes or to maximize the silencing of a singe gene. a) p6-siRNA can express 6 distinct siRNA to suppress the expression of six different genes (Genes A, B, C, D, E and F). b) p6-siRNA can be used to maximize the efficiency of gene silencing (Gene X) by expressing 6 copies of siRNA targeting the same region of Gene X or by expressing 6 distinct siRNA targeting different regions of Gene X.