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Table 2 Media components and their ranges from literature studies used for optimization

From: Enhanced itaconic acid production in Aspergillus niger using genetic modification and medium optimization

Media optimization

Value

reference

Source

 

min (g/L)

max (g/L)

 

C

Glucose

50

140

[9, 10, 13]

N

NaNO3

0.5

2.4

[4]

 

NH4SO4

2.36

2.36

[27]

 

NH4NO3

3.1

5

[9, 10]

P

KH2PO4

0.11

3

[4, 27]

Mg

MgSO4 x 7 H2O

0.24

2.2

[4, 9]

Cu

CuSO4 x 5 H2O

0

0.0025

[4]

Fe

Fe2SO4 x 7 H2O

0.0006

0.0138

[4, 28]

 

FeCl3

0.0006

0.0001

[4, 9]

Mn

MnCl2 x 4 H2O

0

0.007

[11, 27]

Zn

ZnSO4 x 7 H2O

0.0006

0.022

[12]

Ni

NiCl2 x 6 H2O

0

0.0005

[4]

K

KCl

0.52

0.52

[4]

 

NaCl

0,074

2

[4, 27]

 

CaCl2 * 2H2O

0,13

0,2

[4, 27]

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